Skip to main content

Varenicline

ADVERTISEMENT
Identification
Molecular formula
C13H15N3O2
CAS number
274901-16-5
IUPAC name
4-(3-azabicyclo[3.2.2]nonan-3-ylsulfonyl)aniline
State
State

At room temperature, varenicline is in a solid state, typically utilized in the form of tablets or capsules for medicinal purposes.

Melting point (Celsius)
230.00
Melting point (Kelvin)
503.15
Boiling point (Celsius)
100.00
Boiling point (Kelvin)
373.15
General information
Molecular weight
211.28g/mol
Molar mass
211.2500g/mol
Density
1.5000g/cm3
Appearence

Varenicline appears as a white to off-white crystalline solid. It is highly water-soluble and usually utilized in pharmaceutical preparations.

Comment on solubility

Solubility of 4-(3-azabicyclo[3.2.2]nonan-3-ylsulfonyl)aniline

The solubility of 4-(3-azabicyclo[3.2.2]nonan-3-ylsulfonyl)aniline is characterized by several intriguing factors:

  • Polarity: The sulfonyl group present in the compound typically contributes to its overall polar nature, which can enhance its solubility in polar solvents such as water and alcohols.
  • Hydrogen Bonding: The presence of an amine group may allow for the formation of hydrogen bonds with polar solvents, thereby increasing its potential solubility.
  • Structural Implications: The bicyclic system in the compound could introduce steric hindrance, potentially affecting solubility by limiting interaction with solvent molecules.
  • pH Sensitivity: The solubility may vary with changes in pH due to possible protonation of the amine group, which can enhance solubility in acidic conditions.

In summary, while 4-(3-azabicyclo[3.2.2]nonan-3-ylsulfonyl)aniline shows promising characteristics for solubility in various solvents, the interplay of its structural features and environmental factors plays a crucial role in determining its actual solubility behavior. Thus, laboratory solubility tests are essential for accurate assessment.

Interesting facts

Interesting Facts about 4-(3-azabicyclo[3.2.2]nonan-3-ylsulfonyl)aniline

This fascinating compound is a member of a unique class of chemical compounds known as sulfonamides, which are recognized for their essential roles in medicinal chemistry. Specifically, 4-(3-azabicyclo[3.2.2]nonan-3-ylsulfonyl)aniline displays various intriguing characteristics and applications:

  • Medicinal Relevance: Compounds like this one have shown promise in pharmacology, particularly as potential pharmaceutical agents. The inclusion of a sulfonyl group often enhances biological activity, making such compounds valuable in drug development.
  • Structural Diversity: The inclusion of the bicyclic structure (3-azabicyclo[3.2.2]nonane) contributes to the compound's unique three-dimensional shape, which can play a critical role in how it interacts with biological target sites.
  • Analytical Importance: The compound serves as a significant model for researchers studying the interactions of such complex molecules with biological systems, providing insights into medicinal chemistry and drug design.
  • Distinctive Functional Groups: The combination of an aniline moiety and a sulfonyl group can lead to interesting reactivity and properties, which are of interest in organic synthesis and materials science.

As the field of chemistry continues to evolve, compounds like 4-(3-azabicyclo[3.2.2]nonan-3-ylsulfonyl)aniline exemplify the intricate relationship between structure and function in the development of innovative therapeutics. Understanding such compounds not only helps in the design of new drugs but also in revealing the fundamental principles of molecular interactions.


Synonyms
AZABON
1150-20-5
4-(3-azabicyclo[3.2.2]nonan-3-ylsulfonyl)aniline
Azabon (USAN)
4IYS7OKE05
AZABON [USAN]
Benzenamine, 4-(3-azabicyclo(3.2.2)non-3-ylsulfonyl)-
Azabonum
4-(3-Azabicyclo[3.2.2]non-3-ylsulfonyl)benzenamine; 3-Sulfanilyl-3-azabicyclo[3.2.2]nonane
3-Sulfanilyl-3-azabicyclo(3.2.2)nonane
3-Sulfanilyl-3-azabicyclo[3.2.2]nonane
Azabon [USAN:INN]
UNII-4IYS7OKE05
3-Sulfanilyl-3-azabicyclo(3.2.2)nonan
AZABON [INN]
SCHEMBL123797
CHEMBL2103973
DTXSID70150925
CHEBI:177585
NS00125094
D03019
4-(3-azabicyclo[3.2.2]nonan-3-ylsulonyl)aniline
Q27259680
Benzenamine, 4-(3-azabicyclo[3.2.2]non-3-ylsulfonyl)-; 3-Azabicyclo[3.2.2]nonane, 3-[(4-aminophenyl)sulfonyl]- (9CI); 3-Azabicyclo[3.2.2]nonane, 3-sulfanilyl- (7CI,8CI); 3-Sulfanilyl-3-azabicyclo[3.2.2]nonane; Azabon