Skip to main content

Clomiphene

ADVERTISEMENT
Identification
Molecular formula
C26H28ClNO
CAS number
911-45-5
IUPAC name
4-(3-chlorophenyl)-N,N-dimethyl-4-phenyl-but-3-en-1-amine
State
State

At room temperature, Clomiphene is in a solid state. It is commonly used in its citrate form which also appears as a solid.

Melting point (Celsius)
116.50
Melting point (Kelvin)
389.65
Boiling point (Celsius)
475.00
Boiling point (Kelvin)
748.15
General information
Molecular weight
405.97g/mol
Molar mass
405.9650g/mol
Density
0.9221g/cm3
Appearence

Clomiphene typically appears as a white to pale yellow, crystalline powder.

Comment on solubility

Solubility of 4-(3-chlorophenyl)-N,N-dimethyl-4-phenyl-but-3-en-1-amine

The solubility of 4-(3-chlorophenyl)-N,N-dimethyl-4-phenyl-but-3-en-1-amine, often attributed to its unique chemical structure, can be quite complex. This compound, being both hydrophobic and amphiphilic in nature, exhibits varying solubility in different solvents.

Key Aspects of Solubility:

  • Aqueous Solubility: Generally, compounds with significant aromatic systems and long hydrocarbon chains can have low solubility in water. This is likely the case here, leading to low aqueous solubility.
  • Organic Solvents: The presence of the aromatic rings often enhances solubility in non-polar organic solvents such as ethyl acetate or methanol. This compound might dissolve well in these mediums.
  • Temperature Dependency: The solubility may significantly increase with temperature. Warmer conditions can often disrupt solid-state interactions and enhance molecular mobility.
  • pH Influences: With amine functional groups, variations in pH can lead to protonation and affect solubility—typically resulting in increased solubility in acidic conditions.

In summary, the solubility profile of 4-(3-chlorophenyl)-N,N-dimethyl-4-phenyl-but-3-en-1-amine is influenced by various factors, and careful consideration is necessary when selecting solvents for its use. Understanding these solubility characteristics can be critical for applications in synthesis or pharmaceuticals.

Interesting facts

Interesting Facts About 4-(3-Chlorophenyl)-N,N-Dimethyl-4-phenyl-but-3-en-1-amine

This compound, known for its complex structure, belongs to a class of molecules that are often studied in medicinal chemistry due to their diverse pharmacological properties. Here are some compelling aspects of this fascinating compound:

  • Pharmacological Significance: Compounds with similar structures have been explored for their potential use in treating various diseases, including cancer and neurological disorders. Research into this compound's activity may unveil new therapeutic avenues.
  • Chlorine Substitution: The presence of a chlorine atom plays a crucial role in altering the electronic properties of the molecule. It can enhance the compound's lipophilicity, affecting its distribution and absorption in biological systems.
  • Stereo-specificity: The but-3-en-1-amine moiety introduces a degree of geometric isomerism, creating opportunities for studying how different spatial arrangements influence biological activity and pharmacokinetics.
  • Structure-Activity Relationship (SAR): Scientists often conduct SAR studies to identify which modifications lead to enhanced biological functions. This compound's structure makes it a valuable candidate for such investigations.
  • Potential for Drug Development: Given the ongoing search for novel therapeutic agents, this compound could serve as a lead structure in drug discovery programs, underpinning the importance of synthetic organic chemistry in pharmacology.

In summary, 4-(3-chlorophenyl)-N,N-dimethyl-4-phenyl-but-3-en-1-amine exemplifies the rich potential of chemical compounds in medicinal applications. As researchers continue to explore its properties, this compound may contribute significantly to our understanding of therapeutic agents.

Synonyms
724411-44-3
3-Buten-1-amine, 4-(3-chlorophenyl)-N,N-dimethyl-4-phenyl-
DTXSID20274529