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nootropic agent

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Identification
Molecular formula
C16H21NO3
CAS number
314728-85-3
IUPAC name
4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one
State
State

At room temperature, this compound is a solid. It is stable under normal conditions and maintains a solid-state unless subjected to temperatures near its melting point.

Melting point (Celsius)
108.00
Melting point (Kelvin)
381.15
Boiling point (Celsius)
329.00
Boiling point (Kelvin)
602.15
General information
Molecular weight
289.36g/mol
Molar mass
289.3570g/mol
Density
1.2510g/cm3
Appearence

The compound appears as a white to off-white crystalline powder, indicating its purity and stability under standard conditions. It typically forms well-defined crystals and may appear slightly different based on the sample preparation method.

Comment on solubility

Solubility of 4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one

The compound 4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one, with the chemical formula C16H21NO3, exhibits interesting solubility characteristics that are vital for its applications in various domains.

Understanding its solubility can be articulated through several key factors:

  • Polarity: The presence of functional groups such as methoxy (–OCH3) may increase the polarity of the molecule, enhancing its solubility in polar solvents.
  • Hydrogen Bonding: The nitrogen atom in the pyrrolidinone ring can participate in hydrogen bonding, which may contribute to solubility in polar solvents like water and alcohols.
  • Non-Polar Solvents: The cyclopentoxy group suggests affinity towards non-polar solvents such as hexane or toluene, as bulky organic groups often indicate solubility in less polar environments.
  • Temperature Dependence: Like many organic compounds, solubility often increases with rising temperature; thus, this compound's solubility profile might shift under different thermal conditions.

In summary, the solubility of 4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one can be seen as a balance between its polar and non-polar characteristics, making it crucial to evaluate solvent choice based on the specific context of use. As we analyze this compound, one must keep in mind that “solubility is not merely a property of a compound, but a relationship with the solvent.”

Interesting facts

Interesting Facts about 4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one

This intriguing compound, often explored in the realm of medicinal chemistry, showcases the fascinating integration of cyclic and aromatic structures. With its unique architecture, it offers a plethora of intriguing applications and insights:

  • Cyclopentoxy Group: The presence of the cyclopentoxy group contributes to the compound's unique properties, highlighting the importance of cyclic ethers in enhancing molecular diversity.
  • Pyrrolidin-2-one Structure: This compound features a pyrrolidinone ring, a core structure in many pharmacologically active substances, which lends it potential therapeutic effects.
  • Drug Development Potential: With the synthesis of similar compounds, there’s a growing interest in their potential as drug candidates, particularly in areas such as pain relief and neurological disorders.
  • Synthetic Pathways: The design and synthesis of this compound emphasize the intricacies of organic synthesis, where chemists combine ingenuity with precision to achieve structurally complex molecules.

Furthermore, as researchers delve into the complex interactions of this compound with biological systems, it becomes a tantalizing example of how minimal structural changes can lead to significant differences in activity and mechanism of action. "Chemistry is about making connections—between atoms, structures, and even therapeutic properties."

Ultimately, 4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one stands as a testament to the artistry and precision inherent in the field of chemistry, and it beckons further investigation in the quest for novel therapeutic agents.

Synonyms
rolipram
61413-54-5
(R,S)-rolipram
(+/-)-Rolipram
Rolipramum [Latin]
ZK 62711
4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Rolipramum
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Adeo
ZK-62711
Rolipram [USAN:INN]
4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone
4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone
EINECS 262-771-1
NSC-760125
BRN 1588548
DTXSID3044124
ZK 62 711
CHEBI:104872
K676NL63N7
ROLIPRAM [USAN]
ROLIPRAM [INN]
ROLIPRAM [JAN]
ROLIPRAM [MI]
CHEMBL63
ROLIPRAM [MART.]
ROLIPRAM [WHO-DD]
SB 95952
SB-95952
ZK-62771
MLS000069691
2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
DTXCID1024124
Rolipramum (Latin)
NSC 760125
2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-
SMR000058510
ROLIPRAM (MART.)
(R,S)-Rolipram;SB 95952;ZK 62711
4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon
4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one
4-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)PYRROLIDONE
(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
(4R)-4-[3-(Cyclopentyloxy)-4 Methoxyphenyl)pyrrolidin-2-one
(4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-pyrrolidin-2-one
R-(-)-Rolipram
[3H]rolipram
[3H]-rolipram
SR-01000000162
4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidinone
4-[3-Cyclopentyloxy-4-methoxyphenyl]-2-pyrrolidinone
UNII-K676NL63N7
Rolipram?
(plusmn)-rolipram
NCGC00016899-01
(+-)-rolipram
CAS-61413-54-5
MFCD00270906
Rolipram (Standard)
Pyrrolidone, 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-
ME-3167
Opera_ID_1749
Prestwick0_000924
Prestwick1_000924
Prestwick2_000924
Prestwick3_000924
UPCMLD-DP110
Lopac0_001072
SCHEMBL27930
BSPBio_000828
BSPBio_001356
KBioGR_000076
KBioSS_000076
Rolipram (JAN/USAN/INN)
MLS000758273
MLS000759531
MLS001146912
MLS001424084
MLS006010272
SPBio_003007
(+)-Rolipram; (S)-Rolipram
BPBio1_000912
GTPL5260
GTPL5313
4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one
UPCMLD-DP110:001
UPCMLD-DP110:002
BDBM14361
KBio2_000076
KBio2_002644
KBio2_005212
KBio3_000151
KBio3_000152
Bio2_000076
Bio2_000556
HMS1361D18
HMS1570J10
HMS1791D18
HMS1989D18
HMS2051N15
HMS2090J16
HMS2097J10
HMS2232F06
HMS3263G06
HMS3267A05
HMS3369J08
HMS3393N15
HMS3402D18
HMS3411F08
HMS3654P06
HMS3655J21
HMS3675F08
HMS3714J10
Pharmakon1600-01505683
BCP21910
BCP23388
Tox21_110672
Tox21_501072
EX-A10913
HB2896
HY-16900R
NSC760125
Rolipram, solid, >=98% (HPLC)
s1430
Rolipram - CAS 61413-54-5
AKOS015959793
Tox21_110672_1
CCG-100965
CCG-205149
CS-1754
DB01954
FR01270
KS-1400
LP01072
NC00215
SB12922
SDCCGSBI-0051042.P003
IDI1_033826
NCGC00015898-03
NCGC00015898-04
NCGC00015898-05
NCGC00015898-06
NCGC00015898-07
NCGC00015898-08
NCGC00015898-09
NCGC00015898-11
NCGC00015898-12
NCGC00015898-15
NCGC00015898-31
NCGC00089796-02
NCGC00089796-04
NCGC00089796-05
NCGC00089796-06
NCGC00089796-07
NCGC00089796-08
NCGC00261757-01
AC-32927
HY-16900
SBI-0051042.P002
DB-080675
AB00513966
EU-0101072
NS00034678
R0110
SW196583-4
D01783
R 6520
AB00384360-17
AB00384360_19
Q410285
4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidinone
SR-01000000162-3
SR-01000000162-4
SR-01000000162-5
SR-01000000162-9
BRD-A34255068-001-04-8
BRD-A34255068-001-26-1
BRD-A34255068-001-32-9
BRD-A34255068-001-33-7
BRD-A34255068-001-34-5
SR-01000000162-12
4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one
4-(3-cyclopentyloxy-4-methoxyphenyl)-pyrrolidin-2-one
4-[4-Methoxy-3-(cyclopentyloxy)phenyl]-2-pyrrolidinone
2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]- (9CI)
262-771-1