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Isonicotinic acid

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Identification
Molecular formula
C6H5NO2
CAS number
55-22-1
IUPAC name
4-(3-pyridyl)but-3-enoic acid
State
State

At room temperature, isonicotinic acid is generally solid.

Melting point (Celsius)
227.00
Melting point (Kelvin)
500.15
Boiling point (Celsius)
284.00
Boiling point (Kelvin)
557.15
General information
Molecular weight
139.11g/mol
Molar mass
139.1370g/mol
Density
1.2480g/cm3
Appearence

Isonicotinic acid typically appears as a white crystalline solid.

Comment on solubility

Solubility of 4-(3-pyridyl)but-3-enoic acid

4-(3-pyridyl)but-3-enoic acid, with the chemical formula C6H5NO2, exhibits some interesting solubility characteristics:

  • Polar Characteristics: The presence of both a carboxylic acid group (-COOH) and a pyridine ring contributes to the compound's polar nature, enhancing its solubility in polar solvents.
  • Solubility in Water: This compound is generally soluble in water, especially at higher temperatures, due to hydrogen bonding capabilities between the carboxylic acid group and water molecules.
  • Organic Solvents: 4-(3-pyridyl)but-3-enoic acid is also soluble in various organic solvents, including ethanol and methanol, which are capable of solvating polar and nonpolar regions effectively.
  • pH Dependence: The solubility may vary with pH; in lower pH environments, the acid form is more prevalent, which can influence the solubility dynamics.

In summary, the solubility of 4-(3-pyridyl)but-3-enoic acid is influenced by its polar functional groups, making it versatile in both polar and somewhat non-polar solvents. This versatility is crucial for applications in various chemical and pharmaceutical processes.

Interesting facts

Interesting Facts about 4-(3-Pyridyl)but-3-enoic Acid

4-(3-Pyridyl)but-3-enoic acid is a fascinating compound that showcases a unique blend of functional groups and structural features. Here are some key insights about this intriguing molecule:

  • Unique Structure: This compound features both a pyridine ring and a double bond, making it an interesting target for studies in organic synthesis and medicinal chemistry.
  • Biological Relevance: Compounds similar to 4-(3-pyridyl)but-3-enoic acid have been investigated for their potential roles as pharmacophores in drug design, particularly for conditions related to the central nervous system.
  • Synthesis: The molecule can be synthesized through various organic reactions, showcasing the versatility of modern synthetic techniques, including cross-coupling reactions and Michael additions.
  • Research Applications: Studies have highlighted the compound's potential as a ligand in coordination chemistry, where it can form complexes with transition metals, paving the way for new materials and catalysts.
  • Intriguing Properties: The presence of a pyridine ring often imparts unique electronic properties and enhances interactions with biological macromolecules, which is a crucial factor in hit discovery during the drug development process.

As a scientist or chemistry student, delving into 4-(3-pyridyl)but-3-enoic acid opens a plethora of research avenues, enriching our understanding of both its chemical behavior and potential biological applications. Additionally, the exploration of its derivatives can lead to new discoveries in fields ranging from materials science to pharmacology.

Synonyms
4-pyridin-3-yl-but-3-enoic acid
1005327-54-7
(E)-4-pyridin-3-ylbut-3-enoic acid
MHVJWSPYMHAALE-UHFFFAOYSA-N
DTXSID101335829
4-(3-Pyridinyl)-3-butenoic acid
SY359950
NS00115023