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Moxonidine

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Identification
Molecular formula
C20H25N3O5
CAS number
75438-57-2
IUPAC name
4-[3-(tert-butylamino)-2-hydroxy-propoxy]-2-methyl-isoquinolin-1-one
State
State

Moxonidine at room temperature is in solid state, appearing as crystalline powder. It is stable under normal conditions but should be stored in a dry place to preserve its efficacy and integrity.

Melting point (Celsius)
130.50
Melting point (Kelvin)
403.65
Boiling point (Celsius)
407.10
Boiling point (Kelvin)
680.25
General information
Molecular weight
237.31g/mol
Molar mass
237.3060g/mol
Density
1.3652g/cm3
Appearence

Moxonidine appears as a crystalline solid or powder. It is typically characterized by a white color, though it can sometimes display an off-white hue. As a pharmaceutical agent, it is commonly handled in solid form.

Comment on solubility

Solubility of 4-[3-(tert-butylamino)-2-hydroxy-propoxy]-2-methyl-isoquinolin-1-one

The solubility of the compound 4-[3-(tert-butylamino)-2-hydroxy-propoxy]-2-methyl-isoquinolin-1-one, with the chemical formula C20H25N3O5, is influenced by its unique structure and functional groups. Understanding the solubility characteristics of this compound can be crucial for its application in various fields, particularly in pharmaceuticals. Here are some key points to consider:

  • Hydrophilicity vs. Hydrophobicity: The presence of the hydroxyl group (-OH) in the molecule tends to increase its polarity, thereby enhancing its solubility in polar solvents like water.
  • Alkyl Group Influence: The tert-butylamino group provides a degree of steric bulk, which may hinder solubility in certain organic solvents while simultaneously impacting its interaction with water.
  • Solvent Compatibility: This compound may exhibit variable solubility profiles in common solvents. It is expected to have better solubility in organic solvents such as ethanol or DMSO, compared to less polar environments.
  • Temperature Effects: Solubility can be affected by temperature; generally, an increase in temperature can lead to higher solubility in both aqueous and organic solvents.
  • Applications Impact: The solubility implications are critical for its pharmacokinetics, affecting absorption rates and bioavailability, hence impacting its overall effectiveness as a therapeutic agent.

As a result, determining the solubility of 4-[3-(tert-butylamino)-2-hydroxy-propoxy]-2-methyl-isoquinolin-1-one is essential for optimizing its use in scientific and medical contexts. Overall, further empirical studies would provide a clearer picture of its solubility spectrum and practical applications.

Interesting facts

Interesting Facts about 4-[3-(tert-butylamino)-2-hydroxy-propoxy]-2-methyl-isoquinolin-1-one

This fascinating compound, often referred to by its lengthy name, belongs to the isoquinoline family, known for their wide array of biological activities. Here are some intriguing points to consider:

  • Biological Significance: Compounds that contain isoquinoline structures are of great interest in medicinal chemistry. They have been noted for their potential in drug development, particularly in areas such as oncology and neurology.
  • Structure and Function: The presence of various functional groups, such as the tert-butylamino and hydroxy groups, contributes to the compound’s polarity and ability to interact with biological systems. This can influence its solubility, permeability, and overall pharmacokinetics.
  • Potential Uses: Research suggests that this compound could be explored for its therapeutic potential. Studies are ongoing to understand its effects on various biological pathways, which may pave the way for new medicinal applications.
  • Versatility in Synthesis: The synthetic methods for creating isoquinoline derivatives like this one often involve multi-step procedures, showcasing the complexity and creativity involved in modern organic chemistry.
  • Interactions with Receptors: Isoquinolines are known for their interactions with various receptors in the body, which may lead to exciting discoveries in receptor biology and signaling pathways.

As a chemistry student or researcher, delving into the chemistry of such compounds not only enhances your understanding of structure-activity relationships but also broadens your horizon for future discoveries. The process of exploring isoquinoline derivatives is a testament to the intricate interplay between structure and function in medicinal chemistry.

Synonyms
Tilisolol
85136-71-6
Tilisolol [INN]
Tilisololum
Tilisololum [Latin]
UNII-QUF41MF56G
QUF41MF56G
Tilisolol (INN)
4-[3-(tert-butylamino)-2-hydroxypropoxy]-2-methylisoquinolin-1-one
TILISOLOL [MI]
TILISOLOL [WHO-DD]
DTXSID0043846
4-(3(tert-butylamino)-2-hydroxypropoxy)-N-methylisocarbostyril
Tilisololum (Latin)
1(2H)-Isoquinolinone, 4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-2-methyl-
4-(3-tert-Butylamino-2-hydroxypropoxy)-2-methyl-1-isoquinolinone
SCHEMBL49651
CHEMBL1742457
DTXCID8023846
CHEBI:135291
KDA13671
(+-)-4-(3-(tert-Butylamino)-2-hydroxypropoxy)-2-methylisocarbostyril
AKOS025311458
NCGC00538146-01
DB-315753
NS00125536
D08598
L004336
Q7802167