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Loperamide

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Identification
Molecular formula
C29H33Cl2N2O2
CAS number
34552-83-5
IUPAC name
4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoate
State
State

At room temperature, loperamide is a solid substance. It exists in the form of a fine crystalline powder, ensuring ease of incorporation in solid dosage forms such as tablets and capsules.

Melting point (Celsius)
221.00
Melting point (Kelvin)
494.15
Boiling point (Celsius)
522.00
Boiling point (Kelvin)
795.15
General information
Molecular weight
477.50g/mol
Molar mass
477.9100g/mol
Density
1.2028g/cm3
Appearence

Loperamide is typically observed as a white to slightly yellow crystalline powder. It's known for being nearly odorless, allowing it to be easily handled in pharmaceutical applications.

Comment on solubility

Solubility of 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoate

The solubility of the compound 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoate (C29H33Cl2N2O2) can be quite complex, given its intricate structure and functional groups. Understanding the solubility characteristics is essential for various applications, including pharmacological and industrial contexts.

Factors Influencing Solubility

Several factors contribute to the solubility of this compound:

  • Polarity: The presence of polar functional groups, such as the carboxylate group, can enhance solubility in polar solvents.
  • Hydrophobic Interactions: The dipentylamino moiety introduces hydrophobic characteristics, which may decrease solubility in polar solvents but increase it in non-polar environments.
  • Hydrogen Bonding: Potential hydrogen bonding between the compound and solvent can significantly affect solubility.

Solubility Profile

In summary, the solubility of 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoate can be described as follows:

  1. It may have limited solubility in water due to the bulky hydrophobic groups.
  2. It is likely to be more soluble in organic solvents such as dichloromethane or dioxane.
  3. The degree of solubility can vary significantly based on the temperature and pH of the environment.

Understanding the solubility of this compound is crucial for optimizing its application in various chemical processes and formulations.

Interesting facts

Interesting Facts about 4-[(3,4-Dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoate

4-[(3,4-Dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoate is a fascinating compound that showcases the intricate interplay between structural chemistry and biological activity. Here are some noteworthy points about this compound:

  • Unique Structure: The presence of both a dichlorobenzoyl moiety and a dipentylamino group contributes to the compound's complex architecture, which can lead to diverse biological interactions.
  • Potential Biological Applications: Compounds like this one are often studied for their potential roles in pharmaceuticals, particularly in antitumor and antimicrobial therapies. The dichlorobenzoyl component, in particular, may enhance its biological activity due to halogen substitution.
  • Importance of the Oxo Group: The presence of the oxo (carbonyl) group is pivotal in many chemical reactions and biological processes, often participating in nucleophilic attacks and playing a role in enzyme interactions.
  • Synthetic Pathways: The synthesis of such compounds involves various organic reactions, including acylation, condensation, and possibly reductive amination. Understanding these synthetic routes is essential for developing new derivatives.
  • Environmental Considerations: As with many synthetic compounds, understanding their environmental impact and stability is crucial. The chlorinated moieties can pose questions about bioaccumulation and overall ecological effects.

This compound serves as a testament to the complexity and beauty of organic chemistry, demonstrating how variations in molecular architecture can lead to significant differences in activity and application. As research progresses, the future of such compounds may unveil new therapeutic avenues and broaden our understanding of chemical interactions.

Synonyms
BIO-306
CCG-204816
NCGC00162232-01
NCGC00162232-02
NCGC00162232-03
NCGC00162232-09
AB00513961
AB00513961_07