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Lobeline

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Identification
Molecular formula
C22H27NO2F
CAS number
90-69-7
IUPAC name
4-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(4-fluorophenyl)butan-1-one
State
State

Lobeline exists as a solid at room temperature.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
429.80
Boiling point (Kelvin)
702.95
General information
Molecular weight
339.43g/mol
Molar mass
339.4320g/mol
Density
1.1704g/cm3
Appearence

Lobeline is typically a white to off-white crystalline powder. It may have a slight odor typical of alkaloids.

Comment on solubility

Solubility of 4-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(4-fluorophenyl)butan-1-one

The solubility of 4-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(4-fluorophenyl)butan-1-one can be influenced by a variety of factors, making it an intriguing compound to study. As a member of the isoquinoline family, its solubility characteristics can be attributed to the following considerations:

  • Polarity: The presence of both hydrophobic (aromatic) and hydrophilic (aliphatic) portions within the molecule may lead to moderate solubility in organic solvents.
  • Solvent Interactions: Solubility is often highest in non-polar solvents such as chloroform or ether, due to the compound's aromatic system. Conversely, it may show lower solubility in polar solvents like water.
  • Temperature Dependency: Like many organic compounds, the solubility of this compound may increase with temperature, offering enhanced dissolution rates.
  • pH Levels: Since the compound may possess amine functionalities, its solubility could also be affected by the pH of the solution, with extremes in pH potentially enhancing solubility via protonation or deprotonation.

In conclusion, understanding the solubility of this compound involves a multifaceted approach considering its chemical structure, solvent properties, and environmental conditions. This knowledge is pivotal for applications in fields such as pharmaceuticals, where solubility can affect bioavailability and therapeutic effectiveness.

Interesting facts

Interesting Facts about 4-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(4-fluorophenyl)butan-1-one

This fascinating compound is known for its unique structure and potential applications in various fields, particularly in medicinal chemistry. Here are some engaging facts about this intriguing molecule:

  • Molecular Diversity: The compound features an isoquinoline moiety, which contributes to its distinct chemical properties. Isoquinolines are known for their presence in various natural products and pharmaceuticals.
  • Pharmacological Potential: Due to its structural characteristics, this compound may exhibit interesting biological activities, such as antidepressant or antipsychotic effects, making it a target for drug development.
  • Fluorine Substitution: The presence of the fluorophenyl group is particularly noteworthy since fluorine substitution can enhance metabolic stability and lipophilicity, potentially leading to improved pharmacokinetic properties.
  • Synthetic Routes: The synthesis of this compound involves advanced organic reactions, showcasing the importance of synthetic chemistry in creating complex molecules that may hold therapeutic value.
  • Research Interest: Researchers are continuously exploring compounds with isoquinoline structures due to their versatility and potential in the design of new therapeutic agents for various diseases.

In summary, 4-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(4-fluorophenyl)butan-1-one is more than just a molecule; it represents the intersection of structure, activity, and innovation in the field of chemistry and pharmaceuticals.

Synonyms
CHEMBL3818994
4-(3,4-dihydroisoquinolin-2(1H)-yl)-1-(4-fluorophenyl)butan-1-one
NMALCZJKSYZTRE-UHFFFAOYSA-N
Oprea1_034945
Oprea1_173605
SCHEMBL7647981
4-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(4-fluorophenyl)butan-1-one
BDBM50182747
STK004170
AKOS000650068
AB00105385-01
AO-365/15162067
2-((4-(4-Fluorophenyl)-4-oxobutyl))-1,2,3,4-tetrahydroisoquinoline
4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone