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Thioflavin T

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Identification
Molecular formula
C17H19ClN2S
CAS number
2390-54-7
IUPAC name
4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethyl-aniline;chloride
State
State

At room temperature, Thioflavin T is in a solid state, appearing as a yellow crystalline powder.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
257.00
Boiling point (Kelvin)
530.15
General information
Molecular weight
318.86g/mol
Molar mass
318.8550g/mol
Density
1.1800g/cm3
Appearence

Thioflavin T appears as a yellow crystalline powder. It is typically used in solution form for scientific research purposes.

Comment on solubility

Solubility of 4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethyl-aniline;chloride

The solubility of a compound such as 4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethyl-aniline;chloride can vary significantly based on several factors. Here are some essential points to consider:

  • Polarity: The presence of the positively charged +N group in this compound suggests that it may exhibit significant polar characteristics, potentially enhancing its solubility in polar solvents, particularly water.
  • Interactions: Due to the ionic nature of the chloride component, it can further contribute to the solubility in aqueous solutions through ion-dipole interactions.
  • Solvent Effects: This compound is likely to be less soluble in non-polar solvents due to its increased functional groups that favor interactions with polar substances. The rule of thumb states that "like dissolves like," meaning that polar compounds tend to dissolve better in polar solvents.
  • Temperature: Solubility may also vary with temperature; in many cases, increasing temperature can lead to increased solubility in solutions.
  • Concentration: Depending on its concentration in solution, precipitation may occur at higher levels of this compound, indicating a limit to solubility in any given solvent.

In summary, the solubility of this compound is influenced by its ionic nature, polarity, and the nature of the solvent used. Understanding these factors is crucial for predicting its behavior in various chemical environments.

Interesting facts

Interesting Facts about 4-(3,6-Dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethyl-aniline; Chloride

This compound, known for its intriguing structure and properties, offers a window into the fascinating world of organic chemistry and the study of heterocycles. Here are some engaging aspects:

  • Heterocyclic Chemistry: The presence of the benzothiazolium moiety highlights the significance of heterocycles in medicinal chemistry, as these compounds often exhibit remarkable biological activity.
  • Applications in Biology: Compounds similar to this one are frequently researched for their potential applications in antimicrobial and anticancer properties, making them vital to pharmaceutical development.
  • Chromophore Characteristics: The incorporation of the dimethyl-aniline part may contribute to intriguing chromophoric properties, suggesting potential applications in dye chemistry and fluorescence.
  • Solubility Dynamics: As a quaternary ammonium salt, it can exhibit unique solubility properties impacting its interactions in various solvents, which is important for formulation in drug delivery systems.
  • Ion Pair Formation: The chloride ion in the structure can participate in ion pair formation, influencing the compound's reactivity and behavior in biological systems.

As you dive deeper into the study of this compound, you'll uncover layers of complexity that illustrate both the art and science behind chemical synthesis and application. The interplay of structural features and biological activity tantalizes scientists with new avenues for exploration and discovery in the ever-evolving field of chemistry.

Synonyms
Thioflavin T
2390-54-7
Thioflavine T
Basic yellow 1
Setoflavine T
Acronol Yellow TC
Tannoflavine T
Setoflavin T
Thioflavine TG
Rhoduline Yellow
Thioflavin TG
Thioflavine TCN
Citroflavine 8G
Primoflavine 8G
Thioflavin TCN
Basic Yellow T
Purimofurabin 8G
Thioflavine TCND
Acronol Yellow T
Methylene Yellow N
Brilliant Flavine T
Methylene Yellow NI
Thioflavine
Thioflavin TCN extra
Acronol Lake Yellow T
Acronol Lake Yellow TC
Acronol Yellow TC180
Nankai Basic Flavine 8G
Kansai Basic Flavine 8GO
CAX9SG0II0
Methyldehydrothio-p-toluidine sulfonate
CHEBI:76023
3,6-Dimethyl-2-dimethylaminophenylbenzothiazolium chloride
EINECS 219-228-9
NSC 11235
NSC-11235
CI BASIC YELLOW 1
THIOFLAVIN T CHLORIDE
ci 49005
DTXSID10883841
Benzothiazolium, 2-(p-(dimethylamino)phenyl)-3,6-dimethyl-, chloride
2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium chloride
2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride
2-(p-(dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride
2-[4-(DIMETHYLAMINO)PHENYL]-3,6-DIMETHYLBENZOTHIAZOLIUM CHLORIDE
Benzothiazolium, 2-(4-(dimethylamino)phenyl)-3,6-dimethyl-, chloride (1:1)
Benzothiazolium, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-, chloride (1:1)
ThT (dye)
2-(4-(dimethylamino)phenyl)-3,6-dimethyl-1,3-benzothiazol-3-ium chloride
DTXCID801023326
Benzothiazolium, 2-(p-(dimethylamino)phenyl)-3,6-dimethyl-, chloride (8CI)
liiwyxjcrwwpdi-uhfffaoysa-n
2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzo[d]thiazol-3-ium chloride
1326-12-1
C.I. Basic Yellow 1
MFCD00011944
C.I. 49005
Benzothiazolium, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-, chloride
4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride
CHEMBL224392
Benzothiazolium, 2-(4-(dimethylamino)phenyl)-3,6-dimethyl-, chloride
4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline;chloride
2-[4-(Dimethylamino)phenyl]-3,6-dimethylbenzo[d]thiazol-3-ium Chloride
Thioflavin T (ThT)
UNII-CAX9SG0II0
Basic Yellow 1;CI 495
SCHEMBL25298
Thioflavin S;Direct Yellow 7
SCHEMBL11428556
JADVWWSKYZXRGX-UHFFFAOYSA-M
HY-D0218
NSC11235
HB7143
Benzothiazolium,6-dimethyl-, chloride
AKOS016007447
CS-7552
CS-W009025
FT52680
Thioflavin T - CAS 2390-54-7
Thioflavin T, used as stain for amyloid
AS-72625
BP-30130
BP-41752
DA-68149
DA-78423
SY074376
NS00049463
T0558
O10470
A01-0008
Q2033625
2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzo-[d]thiazol-3-ium chloride
2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzo[d]thiazol-3-ium chloride (Thioflavin T)