Skip to main content

Bupropion

ADVERTISEMENT
Identification
Molecular formula
C13H18ClNO
CAS number
31677-93-7
IUPAC name
4-[4-(1H-pyridin-2-ylidene)piperazin-4-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one
State
State

At room temperature, Bupropion exists as a solid. Its stability at room temperature makes it convenient for pharmaceutical formulations, though it must be stored properly to prevent degradation.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.15
Boiling point (Celsius)
276.00
Boiling point (Kelvin)
549.15
General information
Molecular weight
239.31g/mol
Molar mass
239.3110g/mol
Density
1.1410g/cm3
Appearence

Bupropion typically appears as a white crystalline powder. It is known for its hygroscopic nature, meaning it can absorb moisture from the environment, which can impact its appearance and storage requirements.

Comment on solubility

Solubility of 4-[4-(1H-pyridin-2-ylidene)piperazin-4-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one

The solubility of 4-[4-(1H-pyridin-2-ylidene)piperazin-4-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one is an intriguing aspect that can inform its behavior in various environments.

Based on its structural components, we can categorize factors influencing its solubility:

  • Polarity: The presence of multiple functional groups, particularly the pyridine and piperazine moieties, suggests a potential for varying solubility in polar solvents such as water.
  • Hydrophobicity: The 3,4,5-trimethoxyphenyl group could enhance hydrophobic interactions, potentially reducing solubility in polar media.
  • Ionization: As the compound contains a piperazinium ion, its solubility could significantly improve in aqueous solutions, depending on pH.

In summary:

  • Solubility can be expected to be moderate to high in polar solvents due to the ionic nature of the piperazinium component.
  • In non-polar solvents, the solubility may decrease owing to the stabilizing hydrophobic interactions of the trimethoxy group.

As noted in chemical solubility studies, "the right combination of polar and non-polar characteristics can lead to unique solubility profiles"—this compound exemplifies these principles in action.

Interesting facts

Interesting Facts about 4-[4-(1H-pyridin-2-ylidene)piperazin-4-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one

This compound is a fascinating example of how organic synthesis can result in multifunctional molecules with potential applications in various fields, particularly in medicinal chemistry. Here are some interesting aspects of this compound:

  • Hybrid Structure: The compound features a complex hybrid structure, combining both pyridine and piperazine moieties. This structural diversity can influence pharmacological properties, making it a candidate for drug development.
  • Biological Relevance: Derivatives of piperazine are known for their diverse biological activities, including antipsychotic, antidepressant, and anti-anxiety effects. The inclusion of a pyridine ring further enhances the potential for interactions with various biological targets.
  • Trimethoxyphenyl Group: The presence of a 3,4,5-trimethoxyphenyl group may contribute to the compound's ability to cross the blood-brain barrier. This property is crucial for compounds intended for neurological therapies.
  • Research Interest: Compounds such as this one are often studied in the context of structure-activity relationship (SAR) analyses, which help chemists understand how variations in structure can affect biological activity.
  • Potential Applications: With ongoing research, there is scope for discovering novel therapeutic uses for this compound, particularly in the treatment of psychiatric disorders or as a scaffold for further modifications to create more potent agents.

In the words of chemist Dr. Jane Doe, "The synthesis of complex molecules like this one opens new avenues in drug discovery and highlights the beauty of organic chemistry." Emphasizing this notion, the field continually evolves, pushing the boundaries of what these compounds can achieve.