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Fenclorac

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Identification
Molecular formula
C14H17ClFNO2
CAS number
763169-36-6
IUPAC name
4-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]butanoic acid
State
State

At room temperature, it exists as a solid.

Melting point (Celsius)
142.50
Melting point (Kelvin)
415.65
Boiling point (Celsius)
220.50
Boiling point (Kelvin)
493.65
General information
Molecular weight
313.78g/mol
Molar mass
313.7760g/mol
Density
1.2616g/cm3
Appearence

It typically appears as a white solid powder.

Comment on solubility

Solubility of 4-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]butanoic acid

The solubility of 4-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]butanoic acid is influenced by several factors, primarily due to its complex structure. This compound presents unique characteristics that merit a closer examination:

  • Polar and Non-Polar Domains: The presence of both polar (chlorine and fluorine atoms) and non-polar regions (alkyl chain) in its structure creates a delicate balance affecting solubility in various solvents.
  • Aqueous Solubility: Given the presence of the carboxylic acid group, it is likely that this compound exhibits some degree of solubility in water, particularly at physiological pH, where the carboxylic group can be ionized. This means it may behave differently depending on the pH of the solution.
  • Organic Solvents: The hydrophobic alkyl regions may enhance its solubility in organic solvents, including ethanol or dimethyl sulfoxide (DMSO).
  • Concentration Influence: The solubility tends to be concentration-dependent. As concentration increases, the solubility can change due to intermolecular interactions.

In summary, while 4-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]butanoic acid may display some solubility in water due to its ionic potential, it is expected to be more soluble in organic solvents. Understanding its solubility profile is crucial for applications in drug formulation and chemical synthesis.

Interesting facts

Interesting Facts about 4-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]butanoic acid

4-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]butanoic acid is a fascinating compound with notable implications in medicinal chemistry and pharmacology. Here are some key points of interest:

  • Pharmacological Potential: This compound has garnered attention due to its potential use as an anti-cancer agent. Researchers are investigating its ability to inhibit tumor growth by targeting specific pathways involved in cancer proliferation.
  • Structure-Activity Relationship: The unique substituents on the aromatic ring and the butanoic acid moiety contribute significantly to the compound's biological activity. Understanding these relationships is crucial for developing more effective derivatives.
  • Synthesis Challenges: The synthesis of this compound presents certain challenges, particularly in the introduction of the chloro and fluoro functional groups. These challenges require innovative synthetic strategies and careful optimization of reaction conditions.
  • Mechanisms of Action: Research indicates that the compound may interfere with cellular mechanisms, altering apoptosis pathways and affecting cell signaling. This opens new avenues for understanding how structural modifications can enhance therapeutic efficacy.
  • Multi-Target Approach: One of the exciting aspects of this compound is its potential to engage multiple biological targets. This property may lead to more comprehensive treatment strategies that address not just the symptoms but also the underlying causes of disease.

As research continues to evolve, 4-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]butanoic acid may become an important player in the realm of cancer therapeutics and beyond. Its complex structure challenges chemists to innovate and explore new methodologies, ultimately enhancing our understanding of chemical interactions in biological systems.

Synonyms
NSC 85214
BRN 2813843
4092-85-7
BUTYRIC ACID, 4-(p-((2-CHLOROETHYL)(2-FLUOROETHYL)AMINO)PHENYL)-
4-(p-((2-Chloroethyl)(2-fluoroethyl)amino)phenyl)butyric acid
DTXSID40193925
DTXCID80116416
NSC85214
NCIOpen2_004976
NSC-85214