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TFMPP (3-(p-trifluoromethylphenyl)piperazine)

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Identification
Molecular formula
C21H27ClN2O3
CAS number
15532-75-9
IUPAC name
4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one
State
State

At room temperature, this compound exists in a solid state. It is typically handled as a solid in laboratory settings and may be dissolved in solvents for various chemical applications.

Melting point (Celsius)
149.50
Melting point (Kelvin)
422.70
Boiling point (Celsius)
468.15
Boiling point (Kelvin)
741.30
General information
Molecular weight
376.86g/mol
Molar mass
376.8600g/mol
Density
1.2210g/cm3
Appearence

The compound is known to be a crystalline solid that is white or off-white in color. It may also be available as a powder form for specific purposes. This compound, like others in its class, tends to have a neutral odor.

Comment on solubility

Solubility of 4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one

The solubility of 4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one is an essential characteristic that can influence its pharmaceutical application and bioavailability. Here are some important points to consider regarding its solubility:

  • Polarity: The presence of multiple methoxy groups and the piperazine ring contributes to the overall polarity of the compound. This indicates that the solubility profile may change in polar versus non-polar environments.
  • Solvents: It is important to assess solubility in various solvents such as:
    • Water
    • Alcohols
    • Organic solvents (e.g., DMSO, ethanol)
  • Temperature Dependence: Solubility is generally temperature-dependent; thus, increased temperatures may enhance the dissolving capabilities of the compound in selected solvents.
  • pH Sensitivity: The piperazine moiety may render the compound sensitive to pH changes, which could affect its solubility and stability.

In summary, understanding the solubility of 4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one is crucial for its application in drug formulation and chemical studies. As the famous quote goes, "The solubility of a compound is the key to unlocking its potential."

Interesting facts

Overview of 4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one

This compound is a fascinating example of a synthetic organic molecule that exhibits a complex structure, making it of significant interest in medicinal chemistry. The intricate design of 4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one contributes to its potential activities, particularly in the fields of pharmacology and neuroscience.

1. Structural Highlights

  • Piperazine Ring: The presence of the piperazine ring offers a basis for numerous pharmacological properties. This heterocyclic structure is known for its ability to act as a receptor antagonist or agonist, which is vital for targeting various neurotransmitter systems.
  • Chlorophenyl Group: The 2-chlorophenyl substituent enhances the lipophilicity of the compound, potentially influencing its ability to cross the blood-brain barrier and interact with central nervous system receptors.
  • Trimethoxy Substitution: The 3,4,5-trimethoxyphenyl moiety adds to the compound's complexity and may contribute to its biological activity through interactions with various molecular targets, creating opportunities for therapeutic applications.

2. Potential Applications

This compound's unique architecture suggests promising applications in:

  • Psychopharmacology: Given its structural features, it may be developed further as an antidepressant or anxiolytic agent, targeting serotonin receptors.
  • Antipsychotic Research: The piperazine component also indicates potential effectiveness in treating psychotic disorders.
  • Neuroscience Studies: Its ability to modulate neurotransmission may provide insights into cognitive functioning and disorders.

3. Synthesis and Research

The synthesis of this compound involves several steps characteristic of organic synthesis, and ongoing research is focused on optimizing its properties for better efficacy and safety. Researchers are also exploring the mechanisms of action pertinent to its biological activity. As stated by one researcher in medicinal chemistry, “The innovations in synthetic routes open doors to developing highly selective pharmaceuticals that can make a real difference in patient care.”

Thus, 4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one stands as a noteworthy compound in the scientific community, illustrating the interdisciplinary nature of chemistry, biology, and medicine. Its journey from the lab bench to potential therapeutic applications remains an exciting prospect for future research.