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Pipamperone Dihydrochloride

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Identification
Molecular formula
C21H30Cl3N3O3
CAS number
2440-47-5
IUPAC name
4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one;dihydrochloride
State
State

At room temperature, Pipamperone dihydrochloride exists as a solid compound. It is typically found in its crystalline form due to its strong ionic interactions from its salt formation.

Melting point (Celsius)
193.00
Melting point (Kelvin)
466.15
Boiling point (Celsius)
565.45
Boiling point (Kelvin)
838.60
General information
Molecular weight
433.29g/mol
Molar mass
433.2850g/mol
Density
1.2400g/cm3
Appearence

Pipamperone dihydrochloride typically presents as a white to off-white crystalline powder. Its appearance may vary slightly depending on the exact level of hydration or presence of impurities, but in its pure form it remains consistently crystalline.

Comment on solubility

Solubility of 4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one; dihydrochloride

The solubility of 4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one; dihydrochloride can be influenced by its chemical structure and ionic characteristics. Typically, dihydrochloride salts are water-soluble due to the presence of two hydrochloride groups, which favor ionic interactions with water molecules.

Several points to consider regarding its solubility:

  • Solvent Type: The compound is likely to have good solubility in polar solvents, especially water, because of its ionic nature.
  • Temperature Dependence: Higher temperatures might enhance solubility, as increased kinetic energy can promote dissociation of the compound in solution.
  • pH Influence: The solubility may also vary with changes in pH, particularly since it contains basic piperazine moieties.
  • Co-solvents: Addition of organic co-solvents like ethanol or dimethyl sulfoxide (DMSO) might further enhance solubility, owing to their ability to solvate both ionic and non-ionic components.

In summary, the dihydrochloride form of this compound is expected to demonstrate favorable solubility characteristics in aqueous solutions, making it a promising candidate for various pharmaceutical applications. However, precise solubility values would require empirical determination under controlled experimental conditions.

Interesting facts

Interesting Facts about 4-[4-(2-Chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one; Dihydrochloride

This compound, often associated with pharmaceutical research, has encapsulated the attention of scientists due to its potential therapeutic applications. Here are some engaging insights:

  • Pharmacological Significance: This compound belongs to a class of drugs known for their interactions with serotonin receptors, which play a crucial role in mood regulation. The piperazine moiety is particularly intriguing as it is a common structural component in several >medications, especially those addressing psychological disorders.
  • Chemical Diversity: The incorporation of a chlorophenyl group along with a trimethoxyphenyl group highlights the compound's structural complexity. These modifications enhance the biological activity of the compound and improve its selectivity towards certain targets.
  • Research Potential: Ongoing studies suggest that this compound may offer benefits in treating conditions such as anxiety and depression, making it a focal point for therapeutic development. Researchers are exploring how its specific structure contributes to efficacy and safety profiles.
  • Development Challenges: As with many novel compounds, there are challenges regarding bioavailability and side effects that need to be addressed in clinical settings. Understanding the relationship between its chemical structure and biological activity is essential for optimizing its therapeutic potential.

In the words of a prominent researcher in the field: "The journey of understanding compounds like this one is filled with both challenges and possibilities." This sentiment captures the essence of scientific discovery, where each finding paves the way for future innovations.

In summary, 4-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one; dihydrochloride represents a fascinating convergence of chemistry and biology. Its potential to influence therapeutic practices keeps the scientific community engaged and hopeful for new health solutions.

Synonyms
Butyrophenone, 4-(4-(o-chlorophenyl)piperazinyl)-3',4',5'-trimethoxy-, dihydrochloride
17755-85-0
DTXSID70170340
1-(o-Chlorophenyl)-4-(3-(3,4,5-trimethoxybenzoyl)propyl)piperazine dihydrochloride
4-(4-(o-Chlorophenyl)piperazinyl)-3',4',5'-trimethoxybutyrophenone dihydrochloride
Piperazine, 1-(o-chlorophenyl)-4-(3-(3,4,5-trimethoxybenzoyl)propyl)-, dihydrochloride
DTXCID4092831