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Trazodone metabolite

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Identification
Molecular formula
C24H33N2O5
CAS number
21051-74-7
IUPAC name
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol
State
State

At room temperature, this compound exists as a solid. It is stable under standard conditions and does not readily evaporate or sublimate.

Melting point (Celsius)
194.70
Melting point (Kelvin)
467.80
Boiling point (Celsius)
523.15
Boiling point (Kelvin)
796.30
General information
Molecular weight
429.54g/mol
Molar mass
429.5630g/mol
Density
1.1129g/cm3
Appearence

This compound is a white crystalline powder that can appear slightly off-white under different lighting conditions. It is generally odorless and has a smooth texture. When compressed, it forms slightly translucent crystals.

Comment on solubility

Solubility of 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol

The solubility of the compound 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol can be influenced by several factors, primarily due to its complex structure. This compound contains multiple aromatic rings and functional groups that significantly affect its interactions with solvents.

Factors Influencing Solubility:

  • Polarity: The presence of hydroxyl (-OH) groups enhances the compound's ability to dissolve in polar solvents such as water, while the aromatic rings may interact more favorably with non-polar solvents.
  • Hydrogen Bonding: The -OH group can engage in hydrogen bonding, which can improve solubility in protic solvents.
  • Temperature: Higher temperatures may increase solubility due to enhanced molecular motion, facilitating interactions with the solvent.

In general, compounds like this one are often found to be:

  • Soluble in alcohols and dimethyl sulfoxide (DMSO)
  • Partially soluble in water
  • Less soluble in non-polar solvents like hexane

Understanding the solubility profile of such compounds is crucial for their utilization in pharmaceuticals and other applications, as it governs their bioavailability and efficacy. Thus, for specific experiments or applications, conducting solubility tests in various solvents is advisable to ensure optimal performance.

Interesting facts

Interesting Facts about 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol

This compound belongs to the broader class of pharmaceutical agents known for their potential therapeutic effects. It's particularly interesting due to its intricate structure, which features various aromatic and aliphatic components that play a significant role in its biological activity.

Key Highlights:

  • Pharmacological Potential: The compound is being studied for its applications in treating disorders related to the central nervous system. The presence of a piperazine moiety is often associated with antipsychotic and anxiolytic properties.
  • Structure-Activity Relationship: The complex architecture of this compound allows for numerous interactions with biological targets, making it a perfect subject for medicinal chemistry research. Scientists analyze how even slight modifications in its structure can enhance efficacy or reduce side effects.
  • Functional Groups: The inclusion of methoxy groups can increase lipophilicity and might affect the compound's absorption, distribution, metabolism, and excretion. Such considerations are crucial in drug development.
  • Research Significance: The ongoing studies into compounds like this one highlight the importance of interdisciplinary approaches combining organic chemistry, pharmacology, and molecular biology.

As a chemistry student delving into this compound, one might ponder questions like:

  1. How do structural changes influence the compound's behavior and interaction with its target?
  2. What is the impact of the methoxy substituents on the compound's pharmaceutical properties?

In conclusion, 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol exemplifies the intricate connections between structure and function in medicinal chemistry, making it a captivating subject for investigation.