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Meclizine dihydrochloride

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Identification
Molecular formula
C24H32Cl2N2O3
CAS number
3185-12-2
IUPAC name
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol;dihydrochloride
State
State

At room temperature, it is a solid. It is commonly available in the form of a fine or crystalline powder.

Melting point (Celsius)
217.00
Melting point (Kelvin)
490.15
Boiling point (Celsius)
363.00
Boiling point (Kelvin)
636.15
General information
Molecular weight
482.44g/mol
Molar mass
482.4400g/mol
Density
1.3500g/cm3
Appearence

The compound typically appears as a white or almost white crystalline powder.

Comment on solubility

Solubility of 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol; dihydrochloride

The solubility of the compound 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol; dihydrochloride can be influenced by various factors due to its complex molecular structure. Generally, several key points help in understanding its solubility:

  • Polar Nature: The presence of multiple methoxy groups and the piperazine moiety enhances polarity, suggesting a higher likelihood of solubility in polar solvents.
  • Hydrochloride Form: Being a dihydrochloride salt, this compound is expected to exhibit good solubility in water, as salts typically dissolve readily in aqueous environments due to ion-dipole interactions.
  • Temperature Influence: Like many compounds, solubility can increase with temperature; thus, heating the solvent may aid in the dissolution process.
  • pH Sensitivity: The solubility may also be affected by the pH of the solution, with acidic conditions potentially increasing the solubility of the salt form.
  • Solvent Comparison: In organic solvents, solubility can vary significantly, with solvents such as ethanol and methanol often providing better solubility than non-polar solvents.

In conclusion, understanding the solubility of this compound requires consideration of its structural attributes and the environmental conditions under which it is being evaluated. As with many pharmaceutical compounds, finding the optimal conditions for solubility is crucial for its applications.

Interesting facts

Interesting Facts about 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol; dihydrochloride

This intriguing chemical compound exhibits a unique blend of characteristics that make it particularly noteworthy in the field of medicinal chemistry. Here are some interesting aspects:

  • Pharmacological Interest: This compound is known for its potential as a psychoactive agent, and it has attracted attention for its possible implications in treating various neurological disorders.
  • Structural Complexity: Its structure features a piperazine ring, a common motif in many pharmaceutical compounds, which enhances the versatility of the molecule by allowing for varied interactions with biological targets.
  • Substituent Influence: The presence of multiple methoxy groups on the phenyl rings can significantly alter the physicochemical properties of the compound, affecting its lipophilicity and bioavailability.
  • Research Potential: Due to its complex architecture, this compound serves as an interesting subject for structure-activity relationship (SAR) studies, which may lead to the development of more effective derivatives.
  • Formulation Considerations: The dihydrochloride salt form of this compound may enhance its solubility and stability, making it more suitable for pharmaceutical applications.

Scientifically speaking, the exploration of this compound opens doors to a deeper understanding of drug design and development, marrying the intricate chemistry of synthetic routes with potential therapeutic benefits. As noted by researchers, “the subtle shifts in structural components can lead to profound changes in biological activity”, emphasizing the critical role of chemical structure in pharmacology.

In summary, 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol; dihydrochloride stands as a compelling candidate for further investigation, highlighting the intricate connection between chemical properties and biological effects.

Synonyms
16785-29-8
4-(4-(o-Methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-1-butanol dihydrochloride
1-Butanol, 4-(4-(o-methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-, dihydrochloride
4-(4-Hydroxy-4-(3,4,5-trimethoxyphenyl)butyl)-1-(o-methoxyphenyl)piperazine dihydrochloride
DTXSID20937400
4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol--hydrogen chloride (1/2)