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Mirtazapine hydrochloride

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Identification
Molecular formula
C21H27Cl2N3O3
CAS number
61337-67-5
IUPAC name
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one;dihydrochloride
State
State

At room temperature, Mirtazapine hydrochloride is typically in a solid state.

Melting point (Celsius)
116.80
Melting point (Kelvin)
390.00
Boiling point (Celsius)
510.30
Boiling point (Kelvin)
783.50
General information
Molecular weight
499.36g/mol
Molar mass
499.0000g/mol
Density
1.1800g/cm3
Appearence

Mirtazapine hydrochloride appears as a white to slightly yellowish crystalline powder.

Comment on solubility

Solubility of 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one; dihydrochloride

The solubility of this compound, commonly referred to as 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one dihydrochloride, is influenced by its unique chemical structure and the presence of the dihydrochloride salt form.

Key points to consider regarding its solubility include:

  • Salt Form: Being a dihydrochloride salt enhances its solubility compared to the free base form, particularly in aqueous solutions.
  • Polar Interactions: The presence of multiple methoxy groups may contribute to favorable polar interactions with water, leading to increased solubility.
  • pH Sensitivity: The solubility can vary with the pH of the solution, as the ionization state can change, affecting its interaction with water molecules.

In summary, the solubility of this compound is generally expected to be good in water due to its salt form and polar characteristics, making it suitable for various applications where solubility is a critical factor.

Interesting facts

Interesting Facts about 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one; dihydrochloride

This compound, known for its complex structure, is a fascinating example of modern medicinal chemistry. Given its intricate arrangement of functional groups, it has attracted attention for its potential therapeutic applications. Here are some intriguing aspects:

  • Medicinal Potential: The presence of a piperazine ring in its structure hints at possible antidepressant and anxiolytic properties, similar to other piperazine derivatives.
  • Structure-Activity Relationship (SAR): Understanding how modifications to its chemical structure affect biological activity is crucial for drug development. This compound exemplifies how small changes can lead to significant differences in efficacy.
  • Combination of Methoxy Groups: The tri- and di-methoxy phenyl substituents could enhance solubility and interaction with biological targets, making it a subject of interest in pharmacology studies.
  • Research Studies: Compounds of this kind are often explored for their potential use in treating mental health disorders, making them valuable in current neuropharmacological research.

Overall, the exploration of this compound opens up discussions about the interplay between chemistry and therapeutic effects, providing a rich field for ongoing research in organic synthesis and medicinal applications.

Synonyms
Butyrophenone, 4-(4-(o-methoxyphenyl)piperazinyl)-3',4',5'-trimethoxy-, dihydrochloride
17755-87-2
DTXSID30170341
1-(gamma-(3,4,5-Trimethoxybenzoyl)propyl)-4-(o-methoxyphenyl)piperazine dihydrochloride
4-(4-(o-Methoxyphenyl)piperazinyl)-3',4',5'-trimethoxybutyrophenone dihydrochloride
Piperazine, 1-(o-methoxyphenyl)-4-(3-(3,4,5-trimethoxybenzoyl)propyl)-, dihydrochloride
DTXCID9092832