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3,4,5-trimethoxybenzoyl-3'-fluoro-4-aminobutylpiperazine

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Identification
Molecular formula
C21H27FN2O4
CAS number
178729-08-3
IUPAC name
4-[4-(3-fluorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one
State
State

At room temperature, the compound is typically in a crystalline solid state.

Melting point (Celsius)
130.00
Melting point (Kelvin)
403.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
400.45g/mol
Molar mass
400.4510g/mol
Density
1.2945g/cm3
Appearence

The compound appears as a solid crystalline powder. The coloration can vary from off-white to pale yellow, depending on its purity and environmental conditions.

Comment on solubility

Solubility of 4-[4-(3-fluorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one

The solubility of 4-[4-(3-fluorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one can vary significantly depending on the solvent used. Here are some key points to consider:

  • Polar Solvents: This compound is likely to exhibit moderate solubility in polar solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Water
      • (though limited due to its hydrophobic character)
  • Non-polar Solvents: The presence of hydrophobic groups suggests that it may be more soluble in non-polar solvents like:
    • Toluene
    • Chloroform
    • Ethanol
      • (in lower concentrations)
  • pH Influence: The solubility might also be affected by the pH of the solution, as certain functional groups could ionize, altering solubility characteristics.

In conclusion, while this compound has potential solubility in various solvents, its behavior will largely depend on the solvent polarity and the solution's pH. Understanding these factors is vital for applications in drug formulation and chemical synthesis.

Interesting facts

Interesting Facts about 4-[4-(3-Fluorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one

This compound, commonly referred to as an intricate piperazine derivative, holds significance in various fields of research, particularly in medicinal chemistry. Here are some fascinating insights about this compound:

  • Pharmacological Potential: Compounds like this one have been studied for their potential as antidepressants, anxiolytics, and even as antipsychotic agents, showcasing their relevance in treating mental health disorders.
  • Piperazine Core: The presence of a piperazine ring (a six-membered ring containing two nitrogen atoms) is crucial. It is known for enhancing biological activity and improving the interaction with various receptors in the brain.
  • Substituents Matter: The 3-fluorophenyl group adds intriguing properties due to the electron-withdrawing effect of fluorine, which can influence the compound’s affinity for different receptors in the body.
  • Trimethoxyphenyl moiety: The 3,4,5-trimethoxyphenyl group is notable for its potential to enhance lipophilicity, subsequently affecting the compound’s bioavailability and resulting biological effects.
  • Research Opportunities: Current studies are exploring the role of similar compounds in neurological research, especially their capacity to modulate neurotransmitter systems, making them a hotspot in pharmaceutical development.

As a chemist or a student delving into the fascinating world of organic compounds, it is imperative to consider not just the molecular structure but also the potential therapeutic applications that arise from these intricate designs. This compound exemplifies the exciting intersection between chemistry and pharmacology.