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TFMPP

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Identification
Molecular formula
C21H30ClF3N2O3
CAS number
1534-32-1
IUPAC name
4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one;chloride
State
State
TFMPP hydrochloride is typically found in a solid state at room temperature.
Melting point (Celsius)
94.00
Melting point (Kelvin)
367.15
Boiling point (Celsius)
273.50
Boiling point (Kelvin)
546.65
General information
Molecular weight
390.87g/mol
Molar mass
390.8700g/mol
Density
1.3090g/cm3
Appearence

TFMPP hydrochloride appears as a white crystalline solid. It is typically available in powdered form and is known for its characteristic crystalline structure, which is common among many hydrochloride salts.

Comment on solubility

Solubility of 4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one;chloride

The solubility of this compound can be quite complex due to its distinctive structural features. Being a salt, it exhibits some characteristics that are typical of ionic compounds:

  • Polarity: The presence of the piperazin moiety and various methoxy groups suggests a high degree of polarity, which generally enhances solubility in polar solvents like water.
  • Hygroscopic Nature: Compounds containing trifluoromethyl groups can often interact with moisture, potentially leading to improved solubility in polar media.
  • Organic Solvents: Conversely, the aromatic rings in the structure may also allow for decent solubility in organic solvents such as methanol and ethanol, suggesting a dual solubility profile.

In summary, one could say that solubility is influenced by:

  1. Ionization state of the compound.
  2. Polarity of the solvent used.
  3. Temperature, which can affect solubility levels.

As a result, this compound is likely to be soluble in both polar and non-polar solvents, making it versatile for various applications in chemical research and formulation.

Interesting facts

Interesting Facts about 4-[4-[3-(Trifluoromethyl)phenyl]piperazin-1-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one; chloride

This intriguing compound, often referred to by its full name or simply as a derivative of piperazine, possesses a diverse array of chemical properties making it noteworthy in the realm of medicinal chemistry.

Chemical Structure and Characteristics

At the core of this compound is the piperazine moiety, which is well-known for its versatility in pharmacology. The presence of the trifluoromethyl group is significant as it:

  • Increases lipophilicity, enhancing membrane penetration
  • Affects the metabolic stability of the compound due to the electronegative fluorine atoms

The compound also features a trimethoxyphenyl group, which is often associated with antioxidant properties. This part of the molecule can potentially contribute to its biologic effects. The intricate design of its structure opens doors to various applications. Here are a few notable perspectives:

Pharmacological Potential

This compound is a fascinating candidate for drug development, especially in:

  • Nervous System Disorders: The piperazine structure is known to display activity at various neurotransmitter receptors.
  • Antipsychotic Research: Some derivatives based on similar structures have shown promise in treating conditions like schizophrenia or depression.
  • Novel Antimicrobial Agents: The unique structural features may offer a new avenue in combatting resistant bacterial strains.

Research and Innovations

As the scientific community continues to explore the depths of this compound, it's fascinating to note:

  • Ongoing studies aim to elucidate its mechanism of action within biological systems.
  • Its complex molecular structure makes it a target for computer-aided drug design, which can optimize its activity further.

In summary, 4-[4-[3-(Trifluoromethyl)phenyl]piperazin-1-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one; chloride serves as a **testament** to the endless possibilities of chemical synthesis and its implications in the field of drug discovery. As researchers delve deeper into its properties, we may uncover even more remarkable therapeutic potentials.

Synonyms
23771-12-2
Butyrophenone, 3',4',5'-trimethoxy-4-(4-(alpha,alpha,alpha-trifluoro-m-tolyl)-1-piperazinyl)-, monohydrochloride
RefChem:331377