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Trazodone

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Identification
Molecular formula
C19H22F3N3O3
CAS number
19794-93-5
IUPAC name
4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one
State
State

At room temperature, trazodone exists in a solid state as a crystalline powder.

Melting point (Celsius)
87.00
Melting point (Kelvin)
360.15
Boiling point (Celsius)
550.00
Boiling point (Kelvin)
823.15
General information
Molecular weight
371.82g/mol
Molar mass
371.8230g/mol
Density
1.2300g/cm3
Appearence

Trazodone is a white to off-white crystalline powder that is practically odorless.

Comment on solubility

Solubility of 4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one

The solubility of this compound can be influenced by its complex molecular structure, which includes both hydrophobic and hydrophilic domains. As a result, its solubility characteristics can exhibit the following features:

  • Polarity: The presence of the trifluoromethyl group may increase the hydrophobic nature of part of the molecule, leading to lower solubility in water.
  • Functional Groups: The multiple methoxy groups on the aromatic ring can contribute to potential solubility in organic solvents; such groups typically enhance solubility in non-polar or weakly polar solvents.
  • Overall Solubility: It can be expected that the compound is likely to be soluble in organic solvents such as ethanol or DMSO, while having limited solubility in water due to its low polarity.

In conclusion, while the intricate functional groups present in 4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one can offer variegated solubility profiles, it underscores the importance of solvent choice in practical applications.

Interesting facts

Exploring the Intricacies of 4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one

This complex chemical compound belongs to a fascinating class of compounds known as piperazine derivatives. These types of molecules have garnered significant attention due to their varied biological activities. Here are some intriguing aspects of this particular compound:

  • Pharmacological Potential: Many piperazine derivatives are known for their role as pharmaceuticals. This compound might exhibit interesting interactions with receptors in the brain, potentially making it a candidate for research in neuropharmacology.
  • Fluorinated Aromatic Groups: The presence of the trifluoromethyl group enhances lipophilicity and metabolic stability, characteristics that are essential for designing effective pharmaceuticals. This can lead to improved bioavailability and prolonged action.
  • Trimethoxyphenyl Moiety: The 3,4,5-trimethoxyphenyl group contributes to the compound’s unique reactivity and solubility profiles, which can influence biological activities such as antidepressant or anxiolytic effects.
  • Diversity in Synthesis: The synthesis of such compounds can often involve several step reactions. Understanding the reaction pathways not only offers insight into the compound itself but also into methods of creating other similar compounds that may have desirable properties.
  • Potential Applications: Beyond pharmacology, the derivatives of this compound might contribute to research in areas like materials science and organic electronics due to their unique electronic properties.

As a scientist exploring the realms of medicinal chemistry, the study of this compound could provide opportunities to unravel new pathways in drug design. As stated by many pharmacologists, “The most profound discoveries often lie in the intersections of distinct molecular architectures.” Thus, there is still much to learn about the vast implications of compounds like this one, both in therapeutic contexts and beyond.