Skip to main content

Loperamide Hydrochloride

ADVERTISEMENT
Identification
Molecular formula
C29H34ClF3N2O2
CAS number
34552-83-5
IUPAC name
4-[4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxy-piperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one;chloride
State
State

At room temperature, Loperamide Hydrochloride is in a solid state.

Melting point (Celsius)
225.00
Melting point (Kelvin)
498.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
513.50g/mol
Molar mass
513.4980g/mol
Density
1.1900g/cm3
Appearence

Loperamide Hydrochloride typically appears as a white or almost white powder. It is crystalline in nature and is usually odorless or has a faint odor.

Comment on solubility

Solubility of 4-[4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxy-piperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one;chloride

The solubility of this compound, characterized by its complex structure and the presence of ionic and polar functional groups, exhibits significant variability based on the solvent used. Here are several key points regarding its solubility:

  • Water Solubility: Due to its ionic nature from the -ium cation and the chloride counter ion, this compound may show reasonable solubility in water. However, the overall solubility could be compromised by the bulky aromatic groups, which may hinder complete dissolution.
  • Organic Solvents: The compound is likely to demonstrate enhanced solubility in polar organic solvents such as methanol and ethanol because of the hydrophobic aromatic rings, promoting better interactions in such media.
  • Solubility Trends: When considering the temperature and pH of the solution, increased temperatures generally enhance solubility, while varying pH may influence the ionization state and consequently the solubility profile.
  • General Insights: Compounds with similar structural attributes often showcase solubility patterns governed by both hydrophilicity and hydrophobicity, necessitating careful choice of solvents for effective dissolution.

In summary, while this compound demonstrates potential solubility in water and polar organic solvents, experimental validation is crucial to ascertain the precise solubility metrics under varied conditions. As stated, "the solvent makes all the difference" when it comes to chemical solubility.

Interesting facts

Interesting Facts About 4-[4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxy-piperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one;chloride

This compound, often referred to by its shortened name, is an intriguing substance in the realm of chemical research, especially due to its structural complexity and unique properties. Here are some noteworthy points:

  • Structural Diversity: The molecule features a piperidin-1-ium core, which is significant in many pharmacological applications. The presence of both trifluoromethyl and chloro groups enhances its potential reactivity, making it an attractive target for organic synthesis.
  • Pharmaceutical Potential: Compounds with similar structures have often shown promising results in drug discovery, particularly in addressing neurological disorders due to their ability to interact with central nervous system receptors.
  • Impact of Fluorine: The incorporation of fluorine atoms in organic compounds can lead to increased metabolic stability and bioactivity. This compound’s fluorophenyl substituents may contribute to its efficacy in biological systems.
  • Chloride Anion Role: The chloride form of this molecule can influence its solubility and interaction with biological targets. The ion is essential for understanding its behavior in different environments.

Notably, the exploration of such compounds is at the forefront of medicinal chemistry research. As one researcher aptly put it, "Understanding complex molecules like this is crucial for unlocking new therapeutic avenues." Through detailed study, scientists aim to leverage the properties of this compound, potentially leading to significant advancements in healthcare.

Synonyms
Seperol
Seperidol hydrochloride
Seperidol HCl
Clofluperol hydrochloride
Seperidol hydrochloride [USAN]
UNII-JA0GE6S29W
17230-87-4
JA0GE6S29W
Seperidol hydrochloride (USAN)
R9298
R 9298
4-(4-(4-Chloro-3-(trifluoromethyl)phenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone hydrochloride
1-Butanone, 4-(4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-, hydrochloride
Butyrophenone, 4-(4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-hydroxypiperidino)-4'-fluoro-, hydrochloride
R-9298
Speridol hydrochloride
4-[4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one;chloride
4-(4-(4-Chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone hydrochloride
NS00123362
D02685