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Haloperidol

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Identification
Molecular formula
C21H23ClFNO2
CAS number
52-86-8
IUPAC name
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-[4-(dimethylamino)phenyl]butan-1-one
State
State

At room temperature, haloperidol is typically in a solid state as a powder.

Melting point (Celsius)
146.00
Melting point (Kelvin)
419.15
Boiling point (Celsius)
150.00
Boiling point (Kelvin)
423.15
General information
Molecular weight
375.87g/mol
Molar mass
375.8570g/mol
Density
1.4650g/cm3
Appearence

Haloperidol is a white to faintly yellowish powder, practically odorless, and it may appear as crystalline in nature. It does not have a significant characteristic appearance other than its coloration and powdery form.

Comment on solubility

Solubility of 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-[4-(dimethylamino)phenyl]butan-1-one

The solubility of the compound 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-[4-(dimethylamino)phenyl]butan-1-one is an intriguing aspect of its chemical profile. Solubility can often play a critical role in determining a compound's behavior in various applications, including pharmacological usage. Here are some key points regarding its solubility:

  • Polar vs. Non-Polar Solvents: This compound may exhibit greater solubility in polar solvents due to the presence of functional groups like hydroxyl and amino groups, which can form hydrogen bonds.
  • Influence of pH: The solubility can significantly change with variations in pH, particularly because the amino groups can be protonated in acidic conditions, potentially increasing solubility in aqueous environments.
  • Hydrophobic Interactions: With the presence of chlorophenyl and dimethylamino groups, there may also be hydrophobic interactions that could affect its solubility in organic solvents.
  • Temperature Effects: Typically, increasing the temperature could enhance solubility, thus it is advisable to assess this compound's solubility at various temperatures.

In conclusion, understanding the solubility of this compound is essential for predicting its bioavailability and interaction with other substances in both pharmaceutical formulations and chemical processes. As always, empirical testing is recommended to ascertain precise solubility data under specific conditions.

Interesting facts

Interesting Facts About 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-[4-(dimethylamino)phenyl]butan-1-one

This intriguing compound, known for its complex structure and diverse biological properties, features a piperidine ring—a characteristic often associated with medicinal chemistry. The presence of both dimethylamino and chlorophenyl groups contributes to its pharmacological activity, making it a compound of interest in several research domains.

Noteworthy Features:

  • Structure Variety: The integration of different functional groups in its structure allows for a variety of chemical interactions, which is essential for its biological activity.
  • Potential Applications: Compounds with similar structures have been investigated for their effects in areas such as analgesics and psychoactive drugs.
  • Research Interest: Due to its structural complexity, it serves as a template for the design of new compounds with enhanced therapeutic profiles.

As a chemist or chemistry student, understanding the nuances of such compounds can enrich one's grasp of structure-activity relationships. Studying compounds like this one enhances our comprehension of how molecular structure influences biological effects—the cornerstone of medicinal chemistry.

In the words of renowned chemist Robert H. Grubbs, "The most important aspect of any scientific endeavor is the quest for understanding." As we explore compounds such as 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-[4-(dimethylamino)phenyl]butan-1-one, we further this quest, uncovering the intricacies of chemical interactions and their profound implications in medicine.

Synonyms
24671-21-4
S83CV95YBX
NSC-170476
4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-(dimethylamino)phenyl)-1-butanone
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-[4-(dimethylamino)phenyl]-1-butanone
RefChem:1069923
NSC 170476
NSC170476
4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-(dimethylamino)butyrophenone
4-(Dimethylamino)phenyl-3-(4-(4-chlorophenyl)-4-hydroxypiperidino)-propyl ketone
BUTYROPHENONE, 4-(4-(p-CHLOROPHENYL)-4-HYDROXYPIPERIDINO)-4'-(DIMETHYLAMINO)-
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-[4-(dimethylamino)phenyl]butan-1-one
BRN 1507236
4-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-(dimethylamino)phenyl)butan-1-one
UNII-S83CV95YBX
DTXSID60179408
1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-[4-(dimethylamino)phenyl]-
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-dimethylaminophenyl)butan-1-one