Interesting facts
Interesting Facts about 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one
This compound, often referred to in scientific literature due to its intriguing structure and potential applications, sits at the intersection of medicinal chemistry and pharmacology. Here are some interesting insights:
- Pharmacological Relevance: The presence of both chlorophenyl and fluorophenyl groups suggests a potential for significant interactions with biological systems. These halogenated aromatic compounds often enhance binding affinity to biological targets.
- Potential Therapeutic Uses: Compounds with a piperidine backbone are frequently explored for their roles as antidepressants, antipsychotics, and anxiolytics. This particular compound may offer insights into the development of new therapeutic agents.
- Synthesis Challenges: The synthesis of compounds like this can be intricate, requiring multiple steps of functional group transformations. Such processes demand a deep understanding of organic reaction mechanisms and often the use of protecting groups.
- Structure-Activity Relationship (SAR): Researchers often investigate how modifications to the structure affect biological activity. The interplay between the hydroxyl group and the various aromatic rings in this compound can yield critical data in SAR studies.
- Emerging Research: Current studies may focus on the compound's effect on neurotransmitter systems and its potential implications for treating mood disorders, which underscores the importance of continued research in this area.
In conclusion, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one is a fascinating compound with numerous avenues for exploration from a chemical and medicinal perspective. As the field of medicinal chemistry progresses, compounds like this could lead to breakthrough developments in pharmacotherapy.
Synonyms
haloperidol
52-86-8
Haldol
Serenace
Aloperidin
Eukystol
Aloperidol
Brotopon
Serenase
Serenelfi
Linton
Dozic
Einalon S
Aloperidolo
Galoperidol
Halopoidol
Halojust
Halopal
Keselan
Mixidol
Ulcolind
Uliolind
Pernox
Sernas
Sernel
Aldo
Bioperidolo
Lealgin compositum
Sigaperidol
Peluces
Haldol Solutab
Aloperidon
Haloperidolum
Fortunan
Halosten
McN-JR-1625
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Halol
R-1625
177716-59-5
Neurodol
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
NSC 170973
Haloperidolum [INN-Latin]
R 1625
CCRIS 1630
1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine
HSDB 3093
EINECS 200-155-6
4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone
4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone
NSC 615296
NSC-170973
NSC-615296
UNII-J6292F8L3D
BRN 0331267
CHEBI:5613
Haloperidol (Haldol)
DTXSID4034150
4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone
J6292F8L3D
1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-
4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone
CHEMBL54
MFCD00051423
NSC170973
Haldol (TN)
4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
MLS000028450
DTXCID2014150
4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone
4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone
gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone
gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone
5-21-02-00377 (Beilstein Handbook Reference)
Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro-
1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-
VESALIUM COMPONENT HALOPERIDOL
NSC615296
CAS-52-86-8
Haloperidol [USAN:USP:INN:BAN:JAN]
NCGC00015500-10
Aloperidolo [DCIT]
Halidol
Halopidol
Pekuces
SMR000058303
C21H23ClFNO2
Aloperidolo [Italian]
Epoxy resins
4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone
gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone
MDMO-PPV
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one
Haloperidolum (INN-Latin)
HALOPERIDOL (MART.)
HALOPERIDOL [MART.]
HALOPERIDOL (USP-RS)
HALOPERIDOL [USP-RS]
HALOPERIDOL (EP MONOGRAPH)
HALOPERIDOL (USP IMPURITY)
HALOPERIDOL [EP MONOGRAPH]
HALOPERIDOL [USP IMPURITY]
HALOPERIDOL (USP MONOGRAPH)
HALOPERIDOL [USP MONOGRAPH]
Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro-
Haloperidol (USAN:USP:INN:BAN:JAN)
SR-01000003076
Duraperidol
4'-Fluoro-4-[4-hydroxy-4-(4'-chlorophenyl)piperidino]butyrophenone
gamma-[4-(p-chlorophenyl)-4-hydroxypiperidino]-p-fluorobutyrophenone
4-[4-(para-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone
Picroside-III
Haloperidol, 1
4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidyl)-1-(4-fluorophenyl)-butan-1-one
Haloperidol, powder
Prestwick_250
PS14 - Haloperidol
Haloperidol (Standard)
Spectrum_000861
Tocris-0931
starbld0018801
Opera_ID_446
HALOPERIDOL [MI]
4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)
Prestwick0_000115
Prestwick1_000115
Prestwick2_000115
Prestwick3_000115
Spectrum2_001268
Spectrum3_000448
Spectrum4_000570
Spectrum5_000788
HALOPERIDOL [INN]
HALOPERIDOL [JAN]
Lopac-H-1512
HALOPERIDOL [HSDB]
HALOPERIDOL [USAN]
Biomol-NT_000035
GTPL86
Probes1_000255
Probes2_000296
H 1512
HALOPERIDOL [VANDF]
SCHEMBL8264
Lopac0_000583
Oprea1_509923
BSPBio_000130
BSPBio_002096
HALOPERIDOL [WHO-DD]
HALOPERIDOL [WHO-IP]
KBioGR_000980
KBioGR_002390
KBioSS_001341
KBioSS_002395
MLS001146904
BIDD:GT0128
DivK1c_000654
SPECTRUM1500325
SPBio_001236
SPBio_002069
McM-JR-1625
BPBio1_000144
BPBio1_001231
Haloperidol (JP18/USP/INN)
Haloperidol - Bio-X trade mark
BDBM21398
Haloperidol, 1mg/ml in Methanol
HMS502A16
KBio1_000654
KBio2_001341
KBio2_002390
KBio2_003909
KBio2_004958
KBio2_006477
KBio2_007526
KBio3_001316
KBio3_002869
LNEPOXFFQSENCJ-UHFFFAOYSA-
HALOPERIDOL [ORANGE BOOK]
N05AD01
cMAP_000037
Haloperidol for system suitability
NINDS_000654
AC250
Haloperidol for peak identification
HMS1568G12
HMS1920D03
HMS2089M15
HMS2091J09
HMS2095G12
HMS2234P08
HMS3261F08
HMS3370H11
HMS3657I13
HMS3712G12
Pharmakon1600-01500325
BCP33202
Haloperidol 1.0 mg/ml in Methanol
STR04750
Tox21_110162
Tox21_300475
Tox21_500583
CCG-36042
CCG-39111
HALOPERIDOLUM [WHO-IP LATIN]
HY-14538R
NSC757054
STL417208
AKOS000280660
Samarium(III) acetylacetonate xhydrate
Tox21_110162_1
AT13670
CS-1971
DB00502
FH23734
LP00583
NSC-757054
SDCCGSBI-0050565.P005
HALOPERIDOL COMPONENT OF VESALIUM
IDI1_000654
MRF-0000027
QTL1_000042
WLN: T6NTJ A3VR DF& DQ DR DG
NCGC00015500-01
NCGC00015500-02
NCGC00015500-03
NCGC00015500-04
NCGC00015500-05
NCGC00015500-06
NCGC00015500-07
NCGC00015500-08
NCGC00015500-09
NCGC00015500-11
NCGC00015500-12
NCGC00015500-13
NCGC00015500-14
NCGC00015500-15
NCGC00015500-16
NCGC00015500-17
NCGC00015500-19
NCGC00015500-24
NCGC00015500-32
NCGC00016234-01
NCGC00023875-02
NCGC00023875-04
NCGC00023875-05
NCGC00023875-06
NCGC00023875-07
NCGC00023875-08
NCGC00023875-09
NCGC00254503-01
NCGC00261268-01
AC-19691
BH166165
DA-74000
HY-14538
SY052276
SBI-0050565.P004
Haloperidol decanoate impurity, haloperidol-
SC 170973
AB00052008
EU-0100583
H0912
NS00010402
S1920
SW196557-4
C01814
D00136
VU0239704-10
AB00052008-21
AB00052008-22
AB00052008_23
AB00052008_24
L000288
Q251347
SR-01000003076-2
SR-01000003076-8
BRD-K67783091-001-04-8
BRD-K67783091-001-05-5
BRD-K67783091-001-25-3
BRD-K67783091-001-26-1
BRD-K67783091-003-03-6
BRD-K67783091-003-07-7
HALOPERIDOL DECANOATE IMPURITY G [EP IMPURITY]
SR-01000003076-11
Z1590789254
Haloperidol, European Pharmacopoeia (EP) Reference Standard
.gamma.-[4-(p-Chlorphenyl)-4-hydroxpiperidino]-p-fluorbutyrophenone
HALOPERIDOL DECANOATE IMPURITY, HALOPERIDOL- [USP IMPURITY]
Haloperidol, United States Pharmacopeia (USP) Reference Standard
.gamma.-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone
4-(4-HYDROXY-4'-CHLORO-4-PHENYLPIPERIDINO)-4'-FLUORBUTYROPHENONE
Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl) -1-butanone
Haloperidol for peak identification, European Pharmacopoeia (EP) Reference Standard
Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard
200-155-6
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone;R-1625;Aloperidin
4-4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl-1-(4-fluorophenyl)-1-butanone;R-1625;Aloperidin
InChI=1/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
Poly[2-methoxy-5-(3 inverted exclamation marka,7 inverted exclamation marka-dimethyloctyloxy)-1,4-phenylenevinylene]
Solubility of 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one
The compound 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one, with the chemical formula C21H23ClFNO2, exhibits interesting solubility characteristics. Understanding its solubility is vital for applications, formulations, and potential biological activities.
Solubility Characteristics
To summarize, while 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one shows promising solubility in polar solvents, the overall solubility profile is complex, affected by various physical and chemical factors. Striking a balance between its hydrophobic and hydrophilic components is crucial for its effective use in chemical and pharmaceutical applications.