Diphenylpyraline | Solubility of Things

Identification

Molecular formula

C₂₁H₂₇ClN₂O

CAS number

147-20-6

IUPAC name

4-[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenyl-butanamide

State

Diphenylpyraline is generally a solid at room temperature, appearing as a white to off-white crystalline powder.

Melting point (Celsius)

79.00

Melting point (Kelvin)

352.15

Boiling point (Celsius)

375.00

Boiling point (Kelvin)

648.15

General information

Molecular weight

343.91g/mol

Molar mass

343.8880g/mol

Density

1.1000g/cm³

Appearence

Diphenylpyraline typically appears as a white to off-white solid or powder. It is crystalline and may exhibit a light sheen.

Comment on solubility

Solubility of 4-[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenyl-butanamide

The solubility of 4-[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenyl-butanamide, with the chemical formula C₂₁H₂₇ClN₂O, can be characterized by several key factors:

Polarity: This compound contains both hydrophobic (the diphenyl and chlorophenyl groups) and hydrophilic (the hydroxy and ammonium groups) moieties, which suggests a potential for variable solubility in different solvents.
Solvent Compatibility: It is likely to be soluble in polar solvents such as water or alcohols, due to the presence of the hydroxy and ammonium groups that can engage in hydrogen bonding.
Solubility in Organic Solvents: Conversely, it may also exhibit reasonable solubility in nonpolar organic solvents due to its hydrophobic structures, leading to a dual nature that is fairly common among complex organic compounds.
pH Dependence: Given the presence of the piperidinium ion, the solubility may be influenced by the pH of the solution. In acidic conditions, the compound could become more soluble as it remains in its ionized form.

In summary, the solubility of this compound can be described as moderate to high in polar solvents and variable in organic solvents, influenced by both its structural architecture and the environmental conditions.

Interesting facts

Interesting Facts about 4-[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenyl-butanamide

This complex compound, often referred to by its systematic name, stands out due to its multifaceted structure and potential applications in various fields of chemistry and pharmacology. Here are some noteworthy aspects:

Structural Complexity: The compound features a piperidinium moiety with a hydroxy group, indicating potential for hydrogen bonding interactions, which could influence its biological activity.
Pharmacological Potential: The presence of the chlorophenyl group may contribute to its activity as a potential therapeutic agent, making it interesting for drug discovery initiatives.
Dimethylated Amine: With a dimethylamino group, this compound may exhibit strong interactions with biological molecules, suggesting applicability in areas such as neuropharmacology.
Diphenylbutanamide Framework: This unique backbone may offer a balance between lipophilicity and solubility, key factors in drug development.

Additionally, the potential for *ionic forms* at physiological pH lends to its interest in studies targeting membrane-bound proteins or receptors. Researchers are particularly intrigued by how modifications to its substituents can alter its pharmacokinetic profiles and enhance selectivity, paving the way for further investigations.

In summary, 4-[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenyl-butanamide represents a captivating intersection of synthetic organic chemistry and pharmacological research. Its complex structure and potential therapeutic effects make it a compound worth exploring in the quest for new medicinal agents.

Synonyms

loperamide(1+)

4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide

loperamide cation

CHEBI:86969

HMS1361F03

Q27159300

4-(4-chlorophenyl)-1-[4-(dimethylamino)-4-oxo-3,3-diphenylbutyl]-4-hydroxypiperidin-1-ium