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4'-Fluorocetophenone piperidyl

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Identification
Molecular formula
C21H23F2NO2
CAS number
944742-29-2
IUPAC name
4-[4-(4-fluorobenzoyl)-1-piperidyl]-1-(4-fluorophenyl)butan-1-one
State
State

At room temperature, this compound is typically in a solid state.

Melting point (Celsius)
58.00
Melting point (Kelvin)
331.15
Boiling point (Celsius)
453.20
Boiling point (Kelvin)
726.35
General information
Molecular weight
405.46g/mol
Molar mass
405.4580g/mol
Density
1.2633g/cm3
Appearence

The compound typically appears as a solid powder. The color can vary from white to off-white.

Comment on solubility

Solubility of 4-[4-(4-fluorobenzoyl)-1-piperidyl]-1-(4-fluorophenyl)butan-1-one

The solubility characteristics of 4-[4-(4-fluorobenzoyl)-1-piperidyl]-1-(4-fluorophenyl)butan-1-one are important for understanding its potential applications in various fields. Generally speaking, the solubility of a compound is influenced by several key factors, including:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents.
  • Molecular Weight: Higher molecular weight compounds may have lower solubility due to larger size hindering interaction with the solvent.
  • Hydrogen Bonding: Ability to form hydrogen bonds can significantly increase solubility in water.

In terms of general solubility insights:

  • This compound, with multiple aromatic rings and polar functionalities, may exhibit moderate to low solubility in aqueous solutions.
  • Due to its hydrophobic character from the aromatic rings, it could be more soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO).
  • Temperature fluctuations could also influence its solubility behavior, which is common in many organic compounds.

Thus, while specific experimental data would further clarify its solubility profile, one could hypothesize that 4-[4-(4-fluorobenzoyl)-1-piperidyl]-1-(4-fluorophenyl)butan-1-one shows variances in solubility based on the solvent environment and temperature extremes.

Interesting facts

Interesting Facts about 4-[4-(4-fluorobenzoyl)-1-piperidyl]-1-(4-fluorophenyl)butan-1-one

This compound, often referred to as a member of the piperidine family, displays fascinating properties and potential applications in various fields of science. Here are some intriguing insights about this compound:

  • Pharmaceutical Potential: Compounds like this one are frequently explored in medicinal chemistry for their potential use as therapeutic agents. The presence of fluorine atoms can significantly alter the pharmacokinetics and biological activity of the molecule, which is crucial for drug design.
  • Structural Complexity: The compound features a complex structure that includes both a piperidine ring and a ketone group. This structural diversity makes it a prime candidate for studying structure-activity relationships, which are essential for developing more effective drugs.
  • Fluorine's Role: Fluorine is well-known in chemistry for its ability to enhance metabolic stability and selectivity. In this compound, the fluorinated aromatic groups may inhibit certain enzymatic pathways, potentially leading to increased efficacy in therapeutic applications.
  • Research Applications: Besides medicinal applications, compounds like this are being researched for their roles in chemical biology and materials science. They can serve as intermediates or prototypes for designing new molecules with unique properties.
  • Interdisciplinary Interest: The unique properties of this compound foster collaboration across multiple disciplines, including organic chemistry, pharmacology, and materials science, making it a subject of interest for various research groups.

As a result of these characteristics, 4-[4-(4-fluorobenzoyl)-1-piperidyl]-1-(4-fluorophenyl)butan-1-one serves not only as a point of fundamental research but also as a platform for innovation in drug development and related fields.

Synonyms
LENPERONE
24678-13-5
Lenperona
Lenperonum
13P4GX22ES
DTXSID7046120
4'-Fluoro-4-(4-(p-fluorobenzoyl)piperidino)butyrophenone
1-Butanone, 4-(4-(4-fluorobenzoyl)-1-piperidinyl)-1-(4-fluorophenyl)-
AHR-2277 FREE BASE
DTXCID5026120
4-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one
1-Butanone, 4-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-(4-fluorophenyl)-
4'-fluoro-4-(4-(p-fluorobenozyl)piperidino)butyrophenone
4-(4-(4-Fluoro-benzoyl)-piperidin-1-yl)-1-(4-fluoro-phenyl)-butan-1-one
RefChem:152745
246-399-7
AHR 2277
CHEMBL316004
4-(4-(4-Fluorobenzoyl)-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone
Lenperone (USAN)
AHR-2277 [AS HYDROCHLORIDE]
NCGC00160383-01
LENPERONE [USAN]
4-[4-(4-fluorobenzoyl)piperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Lenperonum [Latin]
Lenperona [Spanish]
Lenperone [USAN:INN]
Lenperonum [INN-Latin]
4-(4-(4-fluorobenzoyl)piperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
4-[4-(4-Fluorobenzoyl)-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
Lenperona [INN-Spanish]
AHR2277
NSC303301
EINECS 246-399-7
BRN 1554429
UNII-13P4GX22ES
LENPERONE [INN]
LENPERONE [WHO-DD]
5-21-08-00146 (Beilstein Handbook Reference)
MLS001205808
SCHEMBL121686
orb1702067
CHEBI:230698
HMS2834C09
Tox21 111775
Tox21_111775
BDBM50004320
AKOS040747035
NCGC00160383-02
AS-86466
DA-54850
Lenperone hydrochloride (*hydrochloride*)
SMR000504164
CAS-24678-13-5
HY-114682
CS-0063779
NS00050515
D02668
G78313
Q6523202
Butyrophenone, 4'-fluoro-4-[4-(p-fluorobenzoyl)piperidino]-
4-[4-(4-fluorobenzoyl)-1-piperidyl]-1-(4-fluorophenyl)butan-1-one
4-[4-(4-luorobenzoyl)piperidin-1-yl]-1-(4-luorophenyl)butan-1-one
1-(4-Fluorophenyl)-4-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}butan-1-one
1-Butanone, {4-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-(4-fluorophenyl)-,} hydrochloride
Butyrophenone, {4'-fluoro-4-[4-(p-fluorobenzoyl)piperidino]-,} hydrochloride