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Loperamide Hydrochloride

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Identification
Molecular formula
C29H33ClF2N2O2
CAS number
34552-83-5
IUPAC name
4-[4-(4-fluorobenzoyl)piperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one;chloride
State
State
At room temperature, loperamide hydrochloride is typically found in a solid, powder form.
Melting point (Celsius)
225.00
Melting point (Kelvin)
498.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
513.05g/mol
Molar mass
513.4800g/mol
Density
1.2670g/cm3
Appearence

Loperamide Hydrochloride typically appears as a white to off-white powder. It is crystalline in nature and does not have a distinct odor.

Comment on solubility

Solubility of 4-[4-(4-fluorobenzoyl)piperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one;chloride

The solubility of 4-[4-(4-fluorobenzoyl)piperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one;chloride is influenced by several key factors:

  • Ionic Nature: As a chloride salt, it can exhibit solubility in polar solvents due to the ionic interactions.
  • Polarity: The presence of fluorine atoms may enhance the polarity of the compound, potentially increasing its solubility in polar solvents like water.
  • Hydrogen Bonding: Functional groups in the piperidine ring may facilitate hydrogen bonding, affecting how it interacts with solvents.
  • Concentration: Solubility might increase with concentration, revealing interesting solvation dynamics.

However, it’s important to note that solubility can be quite variable depending on the temperature and solvent conditions. As a general observation, compounds with cationic characteristics like this one tend to have higher solubility in aqueous systems, while hydrophobic regions may hinder solubility in non-polar environments.

In summary, while the solubility of this compound can be expected to be good in polar solvents, precise measurements should be conducted to understand its behavior in various environments.

Interesting facts

Interesting Facts about 4-[4-(4-Fluorobenzoyl)piperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one; Chloride

This chemical compound, known as a piperidine derivative, embodies the fascinating interplay between organic chemistry and medicinal applications. Here are some engaging facts about this compound:

  • Structural Complexity: The presence of both a piperidin-1-ium moiety and fluorinated phenyl groups in its structure highlights the compound's intricate design, often sought after in drug development.

  • Fluorination Impact: Incorporating fluorine atoms enhances the compound’s metabolic stability and bioavailability, making it an attractive candidate for therapeutic agents.

  • Medical Relevance: Compounds featuring piperidine rings are frequently investigated for their potential in treating neurological disorders, showcasing the importance of this derivative in pharmaceutical research.

  • Ionization Properties: The quaternary ammonium structure (piperidin-1-ium) implies that this compound will exhibit particular ionization characteristics, affecting its interaction with biological membranes and its pharmacokinetic profile.

  • Organocatalysis Potential: Due to its unique functional groups, this compound could serve as a catalyst for various reactions in organic synthesis, further demonstrating its versatility.

As we expand our understanding of compounds like this one, we discover not just their chemical properties, but also their potential to contribute significantly to advancements in science and medicine. Efforts to synthesize and explore derivatives of complex organic molecules like 4-[4-(4-fluorobenzoyl)piperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one; chloride continue to unravel new pathways in drug discovery and development.

Synonyms
AHR 2277
4-(4-(p-Fluorobenzoyl)piperidino)-4'-fluorobutyrophenone hydrochloride
NSC 303301
UNII-96Q0TL6O3G
Butyrophenone, 4'-fluoro-4-(4-(p-fluorobenzoyl)piperidino)-, hydrochloride
1-Butanone, 4-(4-(4-fluorobenzoyl)-1-piperidinyl)-1-(4-fluorophenyl)-, hydrochloride
BUTYROPHENONE, 4-(4-(p-FLUOROBENZOYL)PIPERIDINO)-4'-FLUORO-, HYDROCHLORIDE