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Fluoxetine Hydrochloride

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Identification
Molecular formula
C17H19ClFNO3
CAS number
54910-89-3
IUPAC name
4-[4-(4-fluorophenyl)piperazin-1-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one;chloride
State
State
Fluoxetine hydrochloride is typically in a solid state at room temperature. It is often encountered as a crystalline powder.
Melting point (Celsius)
151.00
Melting point (Kelvin)
424.20
Boiling point (Celsius)
321.00
Boiling point (Kelvin)
594.20
General information
Molecular weight
345.79g/mol
Molar mass
345.7900g/mol
Density
1.3536g/cm3
Appearence

Fluoxetine hydrochloride is a white to off-white crystalline solid. It is odorless and slightly hygroscopic, with a tendency to absorb moisture from the air.

Comment on solubility

Solubility of 4-[4-(4-fluorophenyl)piperazin-1-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one; chloride

This compound, which has a complex structure, exhibits high solubility in polar solvents due to the presence of charged functional groups. When analyzing the solubility characteristics, consider the following:

  • Polar Solvents: The ionic nature of the chloride salt enhances its solubility in polar solvents such as water and ethanol. This is primarily due to the ability of these solvents to stabilize charged species.
  • Weak Solvents: Solubility in non-polar solvents is predicted to be low, as the organic moieties do not provide enough interaction with non-polar solvents, limiting effective dissolution.
  • Temperature Effects: Generally, increased temperature may enhance solubility, particularly in polar solvents, due to increased molecular motion and interactions.
  • pH Effects: Because the compound possesses a piperazinium moiety, its solubility may also be affected by pH conditions, which can impact the ionization state of the compound.

In summary, despite the complex structure, the solubility profile of 4-[4-(4-fluorophenyl)piperazin-1-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one; chloride highlights a tendency towards high solubility in polar environments, making it a noteworthy candidate for further pharmaceutical investigation.

Interesting facts

Interesting Facts about 4-[4-(4-fluorophenyl)piperazin-1-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one;chloride

This fascinating compound is part of a diverse class of chemical entities known as piperazine derivatives. These types of compounds have garnered significant interest due to their various applications in medicinal chemistry and psychoactive research.

  • Piperazine Structure: The piperazine ring is a six-membered ring containing two nitrogen atoms at opposite positions. This structure contributes to the compound's ability to interact effectively with biological systems, leading to its potential use in pharmaceuticals.
  • Psychopharmacological Potential: Compounds with piperazine moieties are often investigated for their anxiolytic (anxiety-reducing) and antidepressant properties, which might suggest a role in treating mood disorders.
  • Fluorine Substitution: The presence of a fluorine atom on the phenyl group can enhance the compound's metabolic stability and lipophilicity. This makes it potentially more effective in permeating biological membranes.
  • Trimethoxyphenyl Segment: The 3,4,5-trimethoxyphenyl part not only contributes to the overall pharmacological profile but also indicates possible interactions with neurotransmitter systems, particularly those related to mood regulation and cognition.
  • Synthesis Challenges: The synthesis of such complex molecules often requires meticulous planning and execution in the laboratory, showcasing the challenges and intricacies involved in organic synthesis.

Furthermore, this compound's exploration reflects the ever-evolving nature of chemical science and its potential to unlock new therapeutic avenues. As researchers continue to delve into the depths of this compound, they contribute to the broader understanding of how structural modifications can impact biological activity.

In summary, the study of 4-[4-(4-fluorophenyl)piperazin-1-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-one;chloride provides a compelling example of how chemistry interlinks with biology, paving the way for innovative responses to complex human health challenges.

Synonyms
Butyrophenone, 4-(4-(p-fluorophenyl)-1-piperazinyl)-3',4',5'-trimethoxy-, monohydrochloride
4-(4-(p-Fluorophenyl)-1-piperazinyl)-3',4',5'-trimethoxy-butyrophenone monohydrochloride
23771-10-0
RefChem:331462