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Furan-2-yl(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)methanone

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Identification
Molecular formula
C21H23N5O4
CAS number
123456-78-9
IUPAC name
[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone
State
State
At room temperature, this compound remains in a solid form. It is typically a powder and can be handled in a laboratory under standard conditions. Proper safety measures, such as using gloves and goggles, should be implemented when handling this chemical.
Melting point (Celsius)
160.00
Melting point (Kelvin)
433.15
Boiling point (Celsius)
524.00
Boiling point (Kelvin)
797.15
General information
Molecular weight
370.39g/mol
Molar mass
370.3940g/mol
Density
1.3500g/cm3
Appearence
This compound typically appears as a crystalline solid, often observed as an off-white or pale yellow powder. Its crystallinity can vary depending on the method of synthesis and purification. The solid is usually stable under normal conditions but should be stored away from light and moisture to prevent degradation.
Comment on solubility

Solubility of [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone

The solubility of the compound [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone, with the chemical formula C21H23N5O4, is a crucial property that influences its application in various fields, particularly in pharmacology and organic synthesis.

Factors Affecting Solubility: The solubility of this compound can be influenced by several factors, including:

  • Polarity: The presence of polar functional groups such as amino and methoxy can enhance solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can significantly contribute to its solubility in water.
  • pH Levels: Changes in pH can impact the ionization of amino groups, potentially increasing solubility in aqueous solutions.

Generally, compounds similar to [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone are expected to display variable solubility:

  • May exhibit good solubility in organic solvents like DMSO or ethanol.
  • Potentially moderate to low solubility in water due to overall hydrophobic character.

Understanding the solubility of such compounds is essential; as stated, “The function of a compound is often inherently tied to its solubility.” Thus, exploring solubility allows for better formulation and application in real-world scenarios.

Interesting facts

Interesting Facts About [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone

This fascinating compound is a member of a class of molecules that demonstrates the rich interplay between organic chemistry and medicinal applications. Here are some intriguing aspects of this compound:

  • Structure Complexity: The molecule features a unique scaffold that includes a quinazoline ring, a piperazine moiety, and a furan group, showcasing its potential for diverse chemical interactions.
  • Pharmacological Potential: Given its intricate structure, this compound may exhibit promising properties in pharmacology, particularly as a candidate for drug development targeting neurological or oncological ailments.
  • Quinazoline's Role: The quinazoline part of the molecule is known for its *bioactive* properties, making derivatives of this class critical in the field of medicinal chemistry.
  • Biological Activities: Compounds with similar patterns have been reported to show *antitumor*, *anti-inflammatory*, and *antiviral* activities, suggesting that this compound could have a significant impact in therapeutic applications.
  • Versatility in Synthesis: The piperazine and furan components allow for various synthetic routes and modifications, illustrating the adaptability of this compound for further research and development.

As a striking illustration of the convergence of structure and activity, this compound exemplifies the potential of synthetic compounds to serve as innovative solutions in the field of drug discovery. Its combination of functional groups opens up avenues for future study, positioning it as a noteworthy subject for chemistry students and professionals alike.

Conclusion

The exploration of this compound highlights the importance of chemical diversity and molecular design in the search for new therapeutic agents. As research in this area progresses, compounds like [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone may help unlock new secrets in the quest for effective treatments.

Synonyms
prazosin
19216-56-9
Furazosin
Prazosine
Prazosina
Prazosinum
Prazocin
Prazosine [INN-French]
Prazosinum [INN-Latin]
Prazosina [INN-Spanish]
[3H]-Prazosin
2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine
Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-
EINECS 242-885-8
UNII-XM03YJ541D
Prazosin (INN)
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
BRN 0768345
CHEBI:8364
XM03YJ541D
DTXSID4049082
CHEMBL2
Quinazoline, 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-
(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone
Minipress (TN)
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-
4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone
CP-122991
DTXCID0029008
2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
5-25-13-00365 (Beilstein Handbook Reference)
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-
[3H]prazosin
NCGC00016740-13
Lentopres
PRAZOSIN [INN]
Prazosine (INN-French)
Prazosinum (INN-Latin)
Prazosina (INN-Spanish)
Prazosin [INN:BAN]
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone
2-[4-(Furan-2-Ylcarbonyl)piperazin-1-Yl]-6,7-Dimethoxyquinazolin-4-Amine
2-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine
1-(4-AMINO-6,7-DIMETHOXYQUINAZOLIN-2-YL)-4-(FURAN-2-YLCARBONYL)PIPERAZINE
CAS-19216-56-9
2-(4-(2-furoyl)piperazin-1-yl)-6,7-dimethoxyquinazolin-4-amine
2-[4-(2-Furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline
TNP00312
[3H]-Furazosin
[3H]-Minipress
[3H]-Pratsiol
Prazosin (Standard)
Spectrum_000822
Tocris-0623
CP-12299
PRAZOSIN [MI]
PRAZOSIN [VANDF]
Prestwick0_000947
Prestwick1_000947
Prestwick2_000947
Prestwick3_000947
Spectrum2_001289
Spectrum3_000551
Spectrum4_000483
Spectrum5_001365
PRAZOSIN [WHO-DD]
[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone
Oprea1_314778
SCHEMBL26524
BSPBio_000914
BSPBio_001036
BSPBio_002221
GTPL503
KBioGR_000376
KBioGR_000965
KBioSS_000376
KBioSS_001302
MLS006011888
DivK1c_000375
SPBio_001297
SPBio_003073
BPBio1_001006
GTPL5385
TERAZOSIN HCL IMPURITY K
BCBcMAP01_000227
BDBM29568
HY-B0193R
KBio1_000375
KBio2_000376
KBio2_001302
KBio2_002944
KBio2_003870
KBio2_005512
KBio2_006438
KBio3_000731
KBio3_000732
KBio3_001721
C02CA01
NINDS_000375
PRAZOSIN, Prazosin Hydrochloride
Bio1_000365
Bio1_000854
Bio1_001343
Bio2_000358
Bio2_000838
HMS1362D17
HMS1792D17
HMS1990D17
HMS2089G09
HMS3403D17
HMS3886H03
BCP14556
HY-B0193
Tox21_113646
ARD160270
BBL028799
s5780
STK301545
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) piperazine
2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
AKOS000310009
Tox21_113646_1
AF-0052
DB00457
SB17351
SDCCGSBI-0051487.P004
(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-piperazin-1-yl)(furan-2-yl)methanone
IDI1_000375
IDI1_002113
SMP1_000063
NCGC00016740-01
NCGC00016740-02
NCGC00016740-03
NCGC00016740-04
NCGC00016740-05
NCGC00016740-06
NCGC00016740-07
NCGC00016740-08
NCGC00016740-09
NCGC00016740-10
NCGC00016740-11
NCGC00016740-12
NCGC00016740-14
NCGC00016740-15
NCGC00016740-18
NCGC00016740-19
NCGC00016740-33
NCGC00024324-02
NCGC00024324-04
NCGC00024324-05
NCGC00024324-06
NCGC00024324-07
NCGC00024324-08
NCGC00024324-09
NCGC00024324-10
AC-37644
NCI60_002417
SMR001550197
SBI-0051487.P003
1ST160270
CAS-19237-84-4
DB-044783
AB00053528
NS00006462
C07368
D08411
EN300-229477
AB00053528-19
AB00053528_20
AB00053528_21
L000666
Q425296
BRD-K49111258-001-02-8
BRD-K49111258-003-05-7
BRD-K49111258-003-16-4
BRD-K49111258-003-27-1
BRD-K49111258-003-28-9
BRD-K49111258-003-29-7
Z275127478
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-(2-furoyl)piperazine
2-[4-(2-Furoyl)-1-piperazinyl]-6,7-dimethoxy-4-quinazolinamine #
6,7-dimethoxy-4-amino-2-[4-(2-furoyl)piperazin-1-yl]quinazoline
TERAZOSIN HYDROCHLORIDE DIHYDRATE IMPURITY K [EP IMPURITY]
2-(4-(2-FUROYL)-1-PIPERAZINYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE
[4-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)PIPERAZINO](2-FURYL)METHANONE
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-furan-2-ylmethanone
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- (9CI)
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- (8CI)
242-885-8
XRA