Interesting facts
Interesting Facts about [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
This fascinating compound, often referred to in scientific literature for its diverse biological activities, is a prime example of how intricate molecular designs can lead to significant therapeutic potentials. Here are some notable facts:
- Pharmacological Potential: The compound encompasses a quinazoline moiety, which is a well-known structure in medicinal chemistry. Compounds containing quinazoline derivatives have been reported to exhibit various pharmacological properties, including anticancer, antimicrobial, and anti-inflammatory actions.
- Piperazine Linkage: The inclusion of a piperazine ring enhances its pharmacokinetic profiles, making it a vital component in many pharmaceuticals. Piperazines are recognized for their ability to interact with various neurotransmitter receptors, influencing mood and cognitive function.
- Structure-Activity Relationship (SAR): Its complex structure allows for extensive SAR studies that can lead to the development of more effective analogs. The substitution patterns on the quinazoline and benzodioxin portions can provide insights into modifying activity and selectivity against biological targets.
- Potential Use in Cancer Therapy: Research indicates that compounds with similar structural components have shown promising results in inhibiting tumor growth and proliferation. This positions our compound as a candidate for further preclinical and clinical studies.
- Multi-Target Approach: The unique combination of various pharmacophores suggests that this compound may act on multiple biological pathways, making it a significant subject of interest in drug development for polypharmacy approaches in treating complex diseases.
Scientific exploration into [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone aids in enhancing our understanding of how modifications to molecular frameworks can lead to novel therapeutic agents. As researchers continue to dissect its properties, the future may hold even more astonishing discoveries regarding its application in modern medicine.
Synonyms
doxazosin
74191-85-8
Doxazosine
Doxazosina
Doxazosinum
Doxazosinum [Latin]
(RS)-2-{4-[(2,3-Dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine
Doxazosin (INN)
UNII-NW1291F1W8
1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin
CHEBI:4708
1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin
UK-33274
C02CA04
NW1291F1W8
UK 33274
(+/-)-DOXAZOSIN
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
DTXSID7022964
EC 616-059-6
Doxazosinum (Latin)
2-[4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-
Doxazosine [French]
DOXAZOSIN [INN]
Doxazosina [Spanish]
UK-3327427
Doxazosin [INN:BAN]
(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone
1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-(1,4-BENZODIOXAN-2-YLCARBONYL)PIPERAZINE
(4-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-1-PIPERAZINYL)(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHANONE
(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydro-1,4-benzodioxin-2-yl)methanone
2-[4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl]-6,7-bis(methyloxy)quinazolin-4-amine
Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)-
Cardura XL (TN)
supress
2-(4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl)-6,7-dimethoxyquinazolin-4-amine
Doxazosin; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine; 4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline; UK-33274
METHANONE, (4-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-1-PIPERAZINYL)(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)-
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-
CPD000097306
DOXAZOSIN [MI]
Prestwick0_000858
Prestwick1_000858
Prestwick2_000858
Prestwick3_000858
DOXAZOSIN [VANDF]
ChemDiv2_005017
CHEMBL707
DOXAZOSIN [WHO-DD]
Lopac0_000474
Oprea1_259518
SCHEMBL34111
BSPBio_000875
2-{4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine
SPBio_002796
BPBio1_000963
DTXCID402964
GTPL7170
BDBM86731
HMS1383E01
HMS2090C20
HMS3259N21
HMS3372L09
HMS3886J03
BCP12228
HY-B0098
ZCA19185
NSC768144
NSC768145
s5782
AKOS001681453
AKOS017343634
CCG-118218
CS-1831
DB00590
NC00685
NSC-768144
NSC-768145
SDCCGSBI-0050459.P003
IDI1_003732
NCGC00018158-02
NCGC00018158-03
NCGC00018158-05
NCGC00018158-06
NCGC00018158-08
NCGC00018158-11
NCGC00018158-20
NCGC00089775-02
2-[4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
AC-11062
AS-77104
SBI-0050459.P002
CAS_74191-85-8
DB-055848
UK 33,274
NS00000605
EN300-53055
C06970
D07874
L000738
Q419939
BRD-A13188892-066-03-3
BRD-A13188892-066-13-2
BRD-A13188892-066-21-5
BRD-A13188892-066-22-3
1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine
137888-77-8
2-[4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxy-3,4-dihydroquinazolin-4-imine
Solubility of [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
The solubility of the compound with the formula C24H26N2O4 is influenced by various factors, primarily due to its complex structure. Understanding its solubility characteristics can be pivotal in applications such as drug formulation and material science. Here are some key points regarding its solubility:
In summary, while the exact solubility of this compound is dependent on the specific conditions and solvents used, its structure suggests favorable solubility characteristics in polar environments. For specific applications, empirical testing is recommended to determine precise solubility values.