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Fexofenadine

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Identification
Molecular formula
C32H39NO4
CAS number
83799-24-0
IUPAC name
4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one
State
State

Fexofenadine is typically in a solid state at room temperature. It is usually administered in the form of tablets or capsules for its antihistamine properties.

Melting point (Celsius)
194.50
Melting point (Kelvin)
467.65
Boiling point (Celsius)
532.10
Boiling point (Kelvin)
805.25
General information
Molecular weight
501.67g/mol
Molar mass
501.6680g/mol
Density
1.1625g/cm3
Appearence

Fexofenadine hydrochloride is a white to off-white crystalline powder that is freely soluble in methanol and ethanol, slightly soluble in chloroform, and practically insoluble in water.

Comment on solubility

Solubility of 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one

The solubility of the compound C32H39NO4 can be characterized by several key factors:

  • Polarity: The presence of polar hydroxyl groups contributes to some degree of solubility in polar solvents.
  • Hydrophobic Properties: With a substantial hydrophobic moiety, including the benzhydryloxy and tert-butyl groups, this compound may exhibit limited solubility in water.
  • Solvent Interactions: This compound may show different solubility profiles in various organic solvents. For example, it tends to be more soluble in ethanol and dimethyl sulfoxide (DMSO).

In summary, while C32H39NO4 is expected to have moderate solubility in organic solvents due to its large hydrophobic regions, it may struggle to dissolve in polar solvents like water. Thus, it presents a unique challenge in terms of solvent selection for applications in various chemical processes.


Interesting facts

Interesting Facts about 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one

This compound, known for its complex structure, is a fascinating example of organic chemistry in action. Here are some notable points regarding this intriguing molecule:

  • Pharmacological Potential: Research suggests that compounds with this structure may exhibit interesting biological activities. The presence of a piperidine moiety is often linked to enhanced interactions with biological receptors, making it a subject of interest in medicinal chemistry.
  • Structural Complexity: The combination of a tert-butyl group and a benzyloxy group contributes to the compound's steric hindrance, which can significantly affect its binding affinity and selectivity towards various targets.
  • Application in Drug Design: Compounds like this have been investigated for their potential as therapeutic agents in the treatment of a variety of conditions, including neurological disorders. This highlights the ongoing quest for innovation in pharmaceutical chemistry.
  • Versatility: The multi-functional characteristics of this molecule allow it to serve as a versatile scaffold for the development of new derivatives. This adaptability can lead to the synthesis of compounds with tailored properties to improve efficacy or reduce side effects.

To sum up, 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one exemplifies the intricacies of organic synthesis and the potential for discovery within the world of chemical compounds. As research progresses, it will be exciting to see how compounds of this nature evolve and contribute to advancements in various scientific fields.

Synonyms
ebastine
90729-43-4
Kestine
Ebastel
Ebastin
Ebastina
Bactil
Evastel
Kestin
Ebastinum [Latin]
Ebastina [Spanish]
Ebastinum
LAS W-090
RP 64305
LAS-W-090
MFCD00865661
Ebastine [USAN:INN:BAN]
Kestine (TN)
TQD7Q784P1
DTXSID6046472
RP-64305
1-(4-tert-butylphenyl)-4-[4-(diphenylmethoxy)piperidin-1-yl]butan-1-one
EBASTINE [USAN]
EBASTINE [INN]
EBASTINE [JAN]
EBASTINE [MI]
EBASTINE [MART.]
4-Diphenylmethoxy-1-(3-(4-tert-butylbenzoyl)propyl)piperidine
EBASTINE [WHO-DD]
LAS-W 090;RP64305
RP64305
4-(4-benzhydryloxypiperidin-1-yl)-1-(4-tert-butylphenyl)butan-1-one
4-(4-(benzhydryloxy)piperidin-1-yl)-1-(4-(tert-butyl)phenyl)butan-1-one
EBASTINE [EP IMPURITY]
CHEMBL305660
EBASTINE [EP MONOGRAPH]
DTXCID4026472
4'-tert-Butyl-4-(4-(diphenylmethoxy)piperidino)butyrophenone
Ebastinum (Latin)
1-(4-(1,1-Dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-1-butanone
1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone
NCGC00164603-01
EBASTINE (MART.)
1-Butanone, 1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-
EBASTINE (EP IMPURITY)
EBASTINE (EP MONOGRAPH)
Estivan
Bastel
4-(4-(benzhydryloxy)piperidin-1-yl)-1-(4-tert-butylphenyl)butan-1-one
CAS-90729-43-4
UNII-TQD7Q784P1
4-[4-(Benzhydryloxy)piperidin-1-yl]-1-(4-tert-butylphenyl)butan-1-one
No-Sedat
1-(4-(1,1-Dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)piperidin-1-yl)butan-1-one
1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)piperidin-1-yl]butan-1-one
1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone;Estivan;Ebastel
Ebastine (Standard)
SCHEMBL18467
Ebastine - Bio-X trade mark
Ebastine (JP18/USAN/INN)
BDBM22873
CHEBI:31528
HY-B0674R
R06AX22
HMS3261I03
HMS3887C19
BCP08300
HY-B0674
RYB95313
Tox21_112225
Tox21_500361
BBL029069
Ebastine, >=98% (HPLC), solid
s4262
STK624411
AKOS005557491
Tox21_112225_1
CCG-221665
DB11742
FE22636
KS-1349
LP00361
SDCCGSBI-0633701.P001
NCGC00164603-02
NCGC00164603-04
NCGC00164603-05
NCGC00164603-11
NCGC00261046-01
AC-15213
AC-30629
BE164400
SY053090
DB-057220
E0925
NS00002898
W-090
C77079
D01478
AB01325291-02
EN300-7370483
SR-01000883997
Q2327739
SR-01000883997-1
BRD-K13314656-001-01-0
4-diphenylmethoxy-1[3-(4-tert-butylbenzoyl)propyl]-piperidine
4-[4-(Benzhydryloxy)-1-piperidyl]-1-[4-(tert-butyl)phenyl]-1-butanone
635-609-6