Interesting facts
Interesting Facts about 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
This compound, often associated with medicinal chemistry, is noteworthy for its unique structure and potential pharmacological applications. Here are some intriguing aspects:
- Bioactive Potential: The compound is part of a class of compounds that serve as anticancer agents. Its design includes a bis(2-chloroethyl)amino moiety, which is known to be effective in targeting rapidly dividing cells.
- Synthetic Pathways: The synthesis of this compound typically involves multi-step reactions which may include alkylation and coupling reactions. This complexity showcases the beauty of organic synthesis and the creativity chemists employ when designing new molecules.
- Mechanism of Action: Like many anticancer drugs, it is believed to operate through the formation of cross-links in DNA. This disrupts the cancer cell's ability to replicate, ultimately leading to cell death. The ability to interfere with DNA dynamics makes compounds of this nature invaluable in chemotherapy regimes.
- Research Applications: Ongoing studies focus on understanding the complete pharmacodynamics and pharmacokinetics of this compound. Researchers are particularly interested in how functional groups on the molecule influence its therapeutic efficacy and side effect profile.
- Toxicology and Safety: With great potency comes the necessity for thorough toxicological evaluations. Researchers are continually investigating ways to minimize side effects while maximizing the therapeutic window of such potent compounds.
In summary, 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid embodies the intersection of chemistry and medicine, reminding us of the vast potentials held within organic compounds. As our understanding deepens, compounds like this may not only provide insight into innovative cancer treatments but also inspire the next generation of chemists in their quest for drug discovery.
Synonyms
chlorambucil
305-03-3
Ambochlorin
Leukeran
Chloroambucil
Chloraminophen
Chlorbutin
Chloraminophene
Chlorobutine
Amboclorin
Ecloril
Chlorbutine
Chlorobutin
Lympholysin
Chlocambucil
Linfolizin
Linfolysin
Elcoril
Phenylbutyric acid nitrogen mustard
Leukersan
Leukoran
Chloorambucol
Chlorambucilum
Chlorbutinum
Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-
NSC-3088
Cb l348
Clorambucile
Clorambucilo
4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid
Clorambucile [DCIT]
Phenylbuttersaeure-lost
CB 1348
NSC 3088
Rcra waste number U035
Chlorambucilum [INN-Latin]
Clorambucilo [INN-Spanish]
4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid
4-(4-(Bis(2-chloroethyl)amino)phenyl)butanoic acid
CB-1348
N,N-Di-2-chloroethyl-gamma-p-aminophenylbutyric acid
NCI-C03485
CCRIS 126
CHEBI:28830
Phenylbuttersaeure-lost [German]
4-(Bis(2-chloroethyl)amino)benzenebutanoic acid
4-[Bis(2-chloroethyl)amino]benzenebutanoic acid
HSDB 3026
LEUKERAN (TN)
NSC3088
4-(p-Bis(beta-chloroethyl)aminophenyl)butyric acid
4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
Benzenebutanoic acid, 4-(bis(2-chloroethyl)amino)-
EINECS 206-162-0
MFCD00021783
Chlorambucil [USP:INN:BAN]
BRN 0999011
p-(N,N-Di-2-chloroethyl)aminophenyl butyric acid
4-(p-(Bis(2-chloroethyl)amino)phenyl)butyric acid
DTXSID7020263
gamma-[p-Di(2-chloroethyl)aminophenyl]butyric acid
gamma-(p-Bis(2-chloroethyl)aminophenyl)butyric acid
AI3-26083
NCI-3088
4-[Bis(2-chloroethyl)aminophenyl]butyric acid
4-[Bis(2-chloroethyl)amino]benzenebutyric acid
CHLORAMBUCIL [MI]
p-(N,N-Di-2-chlorethylaminophenyl)butyric acid
CHLORAMBUCIL [INN]
CHLORAMBUCIL [JAN]
CHEMBL515
18D0SL7309
CHLORAMBUCIL [HSDB]
CHLORAMBUCIL [IARC]
gamma-(p-bis(2-chloroethyl)aminophenyl)butyricacid
gamma-(p-Di(2-chloroethyl)aminophenyl)butyric acid
Butanoic acid, 4-(bis(2-chloroethyl)amino) benzene
CHLORAMBUCIL [VANDF]
Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)-
CHLORAMBUCIL [MART.]
CHLORAMBUCIL [USP-RS]
CHLORAMBUCIL [WHO-DD]
CHLORAMBUCIL [WHO-IP]
DTXCID30263
MLS000028443
Kyselina 4-(N,N-bis-(2-chlorethyl)-p-aminofenyl)maselna
Elcorin
4-(Bis(2-chloroethyl)amino)phenylbutyric acid
Kyselina 4-(N,N-bis-(2-chlorethyl)-p-aminofenyl)maselna [Czech]
CHLORAMBUCIL [ORANGE BOOK]
CHLORAMBUCIL [EP MONOGRAPH]
4-14-00-01715 (Beilstein Handbook Reference)
CHLORAMBUCIL [USP MONOGRAPH]
.gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid
CHLORAMBUCILUM [WHO-IP LATIN]
Butyric acid, 4-[p-[bis(2-chloroethyl)amino]phenyl]-
N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid
NCGC00015199-08
CAS-305-03-3
SMR000058372
Leukeran tablets
4-[Bis(2-chloroethyl)amino]phenylbutyric acid
CHLORAMBUCIL (IARC)
Chlorambucilum (INN-Latin)
Clorambucilo (INN-Spanish)
CHLORAMBUCIL (MART.)
CHLORAMBUCIL (USP-RS)
4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid
Butanoic acid, 4-(bis(2-chloroethyl)amino)benzene-
Chlorambucil (USP:INN:BAN)
.gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid
.gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid
Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)-
p-N,N-Di-(.beta.-chloroethyl)aminophenyl butyric acid
C14H19Cl2NO2
CHLORAMBUCIL (EP MONOGRAPH)
CHLORAMBUCIL (USP MONOGRAPH)
SR-01000000062
4-[4-[Bis(2-chloroethyl)amino]phenyl]butyric Acid
CB1348
4-(p-Bis(.beta.-chloroethyl)aminophenyl)butyric acid
4-[p-Bis(.beta.-chloroethyl)aminophenyl]butyric acid
RCRA waste no. U035
chlorambucilddv
clorambucil
GAMMA-[P-BIS(2-CHLOROETHYL)AMINOPHENYL]BUTYRIC ACID
Celkeran
BUTYRIC ACID, 4-(P-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-
Alti-chlorambucil
UNII-18D0SL7309
para-(Di(2-chloroethyl)aminophenyl)butyric acid
Chlorambucil,(S)
phenyl)butanoic acid
p-N,N-Di-(beta-chloroethyl)aminophenyl butyric acid
Butyric acid, 4-(p-(bis(2-chloroethyl)amino)phenyl)
para-N,N-Di(beta-chloroethyl)aminophenyl butyric acid
N,N-Di-2-chloroethyl-gamma-para-aminophenyl butyric acid
Opera_ID_51
Spectrum_000118
Chlorambucil (Standard)
Prestwick0_001079
Prestwick1_001079
Prestwick2_001079
Prestwick3_001079
Spectrum2_000065
Spectrum3_000336
Spectrum4_000273
Spectrum5_000677
Lopac-C-0253
Epitope ID:139977
SCHEMBL4308
4-(p-bis(2-chloroethyl)aminophenyl)butyric acid
Chlorambucil with impurity G
Lopac0_000227
WLN: QV3R DN2G2G
BSPBio_001098
BSPBio_001971
KBioGR_000766
KBioSS_000558
MLS001076130
DivK1c_000688
SPECTRUM1500171
Chlorambucil (JAN/USP/INN)
SPBio_000249
SPBio_002999
BPBio1_001208
GTPL7143
NCL-CO3485
HMS502C10
KBio1_000688
KBio2_000558
KBio2_003126
KBio2_005694
KBio3_001191
L01AA02
NINDS_000688
Chlorambucil for system suitability
HMS1571G20
HMS1920M15
HMS2090M19
HMS2091A22
HMS2098G20
HMS2235A04
HMS3259I10
HMS3372O04
HMS3652P08
Pharmakon1600-01500171
4-(4-(bis(2-chloroethyl)amino)
BCP28394
Tox21_110096
Tox21_201390
Tox21_302996
BDBM50003677
CCG-39872
HY-13593R
NSC756674
s4288
AKOS024319346
Tox21_110096_1
Chlorambucil, purum, >=98.0% (T)
CS-3118
DB00291
GS-6200
LP00227
NC00555
NSC-756674
SDCCGSBI-0050215.P005
IDI1_000688
NCGC00015199-01
NCGC00015199-02
NCGC00015199-03
NCGC00015199-04
NCGC00015199-05
NCGC00015199-06
NCGC00015199-07
NCGC00015199-09
NCGC00015199-10
NCGC00015199-11
NCGC00015199-12
NCGC00015199-13
NCGC00015199-14
NCGC00015199-15
NCGC00015199-16
NCGC00015199-17
NCGC00015199-19
NCGC00015199-20
NCGC00023250-00
NCGC00023250-03
NCGC00023250-04
NCGC00023250-05
NCGC00023250-06
NCGC00023250-07
NCGC00023250-08
NCGC00023250-09
NCGC00023250-10
NCGC00256464-01
NCGC00258941-01
BP-24028
HY-13593
NCI60_002639
SY031075
SBI-0050215.P004
DB-047794
WR-139013
AB00051938
C2939
EU-0100227
NS00009960
SW197258-4
C 0253
C06900
D00266
EN300-123640
H10484
AB00051938-14
AB00051938-15
AB00051938_16
Q415939
4-(4-(Bis(2-chloroethyl)amino)phenyl)butanoicacid
4[p-Bis(.beta.-chloroethyl)aminophenyl]butyric acid
butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)
p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid
SR-01000000062-2
SR-01000000062-4
SR-01000000062-7
.gamma.-(p-bis(2-chloroethyl)aminophenyl)butyricacid
BRD-K29458283-001-04-2
BRD-K29458283-001-05-9
BRD-K29458283-001-17-4
BRD-K29458283-001-29-9
P-(N,N-DI-2-CHLORETHYLAMINOPHENYL BUTYRIC ACID
p-N, N-Di-(beta-chloroethyl)aminophenyl butyric acid
4-(4-[Bis(2-chloroethyl)amino]phenyl)butanoic acid #
p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid
Z1552153009
4-[4-(N,N-bis(2-chloroethyl)-amino]phenyl)butanoic acid
Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-(9CI)
Chlorambucil, European Pharmacopoeia (EP) Reference Standard
Chlorambucil, United States Pharmacopeia (USP) Reference Standard
Benzenebutanoic acid, alpha-amino-4-(bis(2-chloroethyl)amino)-(9CI)
Chlorambucil for system suitability, European Pharmacopoeia (EP) Reference Standard
206-162-0
Solubility of 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid (C14H19Cl2NO2)
The solubility of 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid is influenced by its chemical structure and the presence of polar functional groups. This compound features a carboxylic acid group, which is known for its ability to enhance solubility in polar solvents. Consider the following key points regarding its solubility:
Moreover, it is essential to assess solubility at varying temperatures and pH levels since these factors can significantly alter the behavior of the compound in solution. Solubility can often be somewhat unpredictable, and empirical testing is necessary to determine precise solubility limits in various solvents.
In summary, while the solubility of 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid displays potential in polar environments, its overall behavior is contingent upon a wider spectrum of interacting factors in any given solvent system.