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4-(4-chlorophenoxy)aniline

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Identification
Molecular formula
C12H10ClNO
CAS number
6393-45-1
IUPAC name
4-(4-chlorophenoxy)aniline
State
State

At room temperature, 4-(4-Chlorophenoxy)aniline is in a solid state.

Melting point (Celsius)
71.00
Melting point (Kelvin)
344.15
Boiling point (Celsius)
401.00
Boiling point (Kelvin)
674.15
General information
Molecular weight
217.66g/mol
Molar mass
217.6550g/mol
Density
1.2600g/cm3
Appearence

4-(4-Chlorophenoxy)aniline appears as a crystalline solid. The compound can vary in color from white to slightly beige.

Comment on solubility

Solubility of 4-(4-chlorophenoxy)aniline

4-(4-chlorophenoxy)aniline is a compound that exhibits notable solubility characteristics which can vary depending on the solvent used. Understanding its solubility helps in applications such as chemical synthesis, pharmaceuticals, and environmental studies. Here are some pertinent points regarding the solubility of this compound:

  • Polar Solvent Interaction: 4-(4-chlorophenoxy)aniline tends to be more soluble in polar solvents due to the presence of amine and ether functional groups. For instance, solvents like ethanol and methanol can dissolve this compound effectively.
  • Aprotic Solvents: The solubility in aprotic solvents such as dimethyl sulfoxide (DMSO) is also favorable. This characteristic makes it useful in various organic reactions.
  • Hydrocarbon Limitations: When it comes to non-polar solvents or hydrocarbons, solubility tends to be limited. Compounds like hexane or benzene do not facilitate a good dissolving environment for 4-(4-chlorophenoxy)aniline.

It is important to note that solubility can be significantly affected by temperature. As temperature increases, the solubility of this compound typically improves in most solvents. This phenomenon is largely attributed to the enhanced molecular movement, facilitating greater interactions between solute and solvent molecules.

In summary, while 4-(4-chlorophenoxy)aniline shows considerable solubility in polar and aprotic solvents, its limited solubility in non-polar environments is crucial to bear in mind for practical applications. Engaging with its solubility profile can lead to better experimental designs and outcomes.

Interesting facts

Exploring 4-(4-Chlorophenoxy)aniline

4-(4-Chlorophenoxy)aniline, also known as p-chlorophenoxyaniline, is a fascinating compound that intrigues chemists and industry professionals alike. Here are some intriguing facts about this compound:

  • Structural Significance: The molecule features both an aniline group and a chlorophenoxy group, allowing it to participate in diverse chemical reactions and making it a versatile building block in organic synthesis.
  • Biological Relevance: Research has highlighted its potential application in the pharmaceutical industry due to its ability to interact with biological systems. Compounds similar to 4-(4-chlorophenoxy)aniline have been investigated for their anti-cancer properties.
  • Synthesis: This compound can be synthesized through various methods, including nucleophilic aromatic substitution. Chemists often utilize creative strategies to assemble its complex structure efficiently.
  • Environmental Considerations: The presence of chlorine in its structure indicates that handling and disposal must be carried out with care. It is essential to understand its environmental impact, especially in industrial settings.
  • Applications in Research: Known for its applications in material science, 4-(4-chlorophenoxy)aniline is being studied for its role in the development of advanced polymers and dyes, showcasing its importance beyond just pharmaceuticals.

In summary, 4-(4-chlorophenoxy)aniline embodies the intersection of organic chemistry, biology, and materials science. Its multifaceted nature allows it to be a subject of continued study and innovation, solidifying its importance in both academic and industrial realms.

Synonyms
4-(4-Chlorophenoxy)aniline
101-79-1
4-Amino-4'-chlorodiphenyl ether
Benzenamine, 4-(4-chlorophenoxy)-
4-(4-Chlorophenoxy)benzenamine
p-(p-Chlorophenoxy)aniline
4-Chloro-4'-aminodiphenyl ether
Aniline, p-chlorophenoxy-
4-Amino-4-chlorodiphenyl ether
ANILINE, p-(p-CHLOROPHENOXY)-
4'-Chloro-4-aminobiphenyl ether
[4-(4-chlorophenoxy)phenyl]amine
EINECS 202-976-5
NSC 75571
BRN 0782540
4-Chloro-4'-aminodiphenylether
DTXSID1020275
MFCD00043925
DTXCID10275
4-Amino-4'-chlorodiphenylether
CHEMBL1521156
3-13-00-00999 (Beilstein Handbook Reference)
NSC-75571
(4-(4-chlorophenoxy)phenyl)amine
4-(4'-chlorophenoxy)aniline
4-[(4-chlorophenyl)oxy]aniline
NSC75571
WLN: ZR DOR DG
CSQ9MY7PQ9
Cambridge id 5128184
NCIOpen2_004533
Oprea1_021499
CBDivE_002845
MLS000532683
SCHEMBL177721
4-(4'-chlorophenoxy) aniline
4-(4-chlorophenyloxy) aniline
4-amino-4'-chloro diphenylether
4-Amino-4/'-chlorodiphenyl ether
4-Amino-4\'-chlorodiphenyl ether
Chloro-4'-aminodiphenylether, 4-
HMS2483B24
4-(4-Chlorophenoxy)aniline, 97%
Tox21_200985
BDBM50334279
STK360048
AKOS000101561
PS-7880
SB79369
NCGC00245707-01
NCGC00245707-02
NCGC00258538-01
AC-15759
CAS-101-79-1
SMR000140121
SY035502
CS-0100482
NS00021445
EN300-116842
SR-01000196380
SR-01000196380-1
BRD-K58076685-001-06-5
Q63088169
Z57124587
202-976-5