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4-(4-fluorophenyl)aniline

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Identification
Molecular formula
C12H10FN
CAS number
367-21-5
IUPAC name
4-(4-fluorophenyl)aniline
State
State

The compound is in a solid state at room temperature, appearing as crystalline solids. Its structural integrity is maintained under standard conditions.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
189.22g/mol
Molar mass
189.2160g/mol
Density
1.1876g/cm3
Appearence

4-(4-fluorophenyl)aniline typically appears as a white to off-white crystalline solid. Its structure contains an aniline group connected to a biphenyl system where one of the phenyl rings is substituted with a fluorine atom at the para position.

Comment on solubility

Solubility of 4-(4-fluorophenyl)aniline

4-(4-fluorophenyl)aniline, with its unique structure, presents some interesting insights regarding its solubility characteristics.

General Solubility Characteristics

This compound is an aromatic amine, which influences its solubility profile in various solvents. The solubility can typically be classified based on the following points:

  • Polar Solvents: 4-(4-fluorophenyl)aniline tends to be more soluble in polar solvents due to its amine functional group, which can engage in hydrogen bonding.
  • Nonpolar Solvents: In contrast, its solubility diminishes in nonpolar solvents due to a lack of favorable interactions, highlighting its dependency on polarity.
  • pH Sensitivity: The solubility can also be affected by the pH of the solution, where increased acidity may enhance its solubility as it can protonate the amine group.

Solubility Limitations

Notably, it is important to consider:

  • The presence of the fluorine substituent impacts the overall polarity of the molecule.
  • 4-(4-fluorophenyl)aniline may have limited solubility in water, as many organic compounds with bulky aromatic structures tend to do.

In summary, while 4-(4-fluorophenyl)aniline exhibits a degree of solubility in polar solvents, factors such as polarity, solvent type, and solution pH significantly determine its overall solubility behavior. As noted, "the interaction of functional groups with solvents is key to understanding solubility."

Interesting facts

Interesting Facts about 4-(4-Fluorophenyl)aniline

4-(4-Fluorophenyl)aniline is a fascinating compound in the realm of organic chemistry. This aromatic amine showcases unique properties due to its functional groups and structure. Here are some intriguing aspects worth exploring:

  • Aromatic System: The compound features an aromatic ring which contributes to its stability and reactivity. Aromatic compounds are known for their delocalized electrons, making them less reactive than aliphatic compounds.
  • Fluorine Substitution: The presence of a fluorine atom has significant implications. Fluorine is highly electronegative, and its substitution can enhance the compound’s lipophilicity, leading to improved biological activity.
  • Applications: Due to its chemical properties, 4-(4-Fluorophenyl)aniline may be used in various applications including the synthesis of pharmaceuticals, agrochemicals, and organic materials.
  • Biological Research: The compound's derivatives are often studied for their potential biological activities. Researchers investigate the interaction of such compounds with biological targets for drug development.

As with many organic compounds, it is essential to consider *safety measures* when working with 4-(4-fluorophenyl)aniline due to its potential health risks. Understanding compounds like this one can illuminate the broader principles of organic chemistry and the interactions that govern the behavior of various substances.

In summary, 4-(4-Fluorophenyl)aniline is not just a chemical entity but a gateway to understanding concepts of reactivity, substitution effects, and applications in real-world scenarios. As scientists continue to investigate its properties, we can expect exciting developments and discoveries!

Synonyms
324-93-6
4-Amino-4'-fluorobiphenyl
4-(4-Fluorophenyl)aniline
4'-Fluoro-[1,1'-biphenyl]-4-amine
4'-Fluoro-4-aminobiphenyl
4'-Fluoro-4-aminodiphenyl
4'-Fluoro-biphenyl-4-ylamine
[1,1'-Biphenyl]-4-amine, 4'-fluoro-
4-(p-Fluorophenyl)aniline
4'-Fluoro-4-biphenylamine
4-BIPHENYLAMINE, 4'-FLUORO-
4'-fluorobiphenyl-4-amine
4-Amino-4'-fluorodiphenyl
4-Amino-4'-fluorbifenyl
NSC 88341
4'-Fluoro-biphenyl-4-amine
(1,1'-Biphenyl)-4-amine, 4'-fluoro-
MFCD00025338
LL87GJV2VC
4'-Fluoro(1,1'-biphenyl)-4-amine
4'-Fluoro-p-phenylaniline
DTXSID7020631
NSC-88341
CCRIS 1569
4-Amino-4'-fluorbifenyl [Czech]
EINECS 206-306-2
BRN 2936239
4'-Fluorobiphenyl-4-ylamine
AI3-50465
NSC88341
UNII-LL87GJV2VC
[1, 4'-fluoro-
WLN: ZR DR DF
NCIOpen2_001407
CHEMBL83147
DTXCID50631
SCHEMBL125516
4'-fluorobiphenyl-4-yl amine
Amino-4'-fluorobyphenyl, 4-
(4'-Fluorobiphenyl-4-yl)amine
ALBB-037480
Tox21_302275
AKOS000302725
AB01463
4'-Fluoro[1,1'-biphenyl]-4-amine #
NCGC00255397-01
BS-32274
CAS-324-93-6
SY111317
DB-048227
NS00041860
C78141
EN300-2687135
4-Amino-4 inverted exclamation mark -fluorobiphenyl
Q63088209
Z667445760