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4-Methoxyphenylpiperazine

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Identification
Molecular formula
C21H26N2O4
CAS number
38212-33-4
IUPAC name
[4-(4-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
State
State

At room temperature, this compound is generally in a solid state.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.00
Boiling point (Celsius)
512.00
Boiling point (Kelvin)
785.15
General information
Molecular weight
344.39g/mol
Molar mass
344.3860g/mol
Density
1.2000g/cm3
Appearence

The compound is typically a white to off-white crystalline powder. It may appear slightly hygroscopic and should be stored in a dry place.

Comment on solubility

Solubility of [4-(4-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone

The solubility of the compound [4-(4-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone can be influenced by several factors, which are important to understand for its applications in various fields. Here are some essential points regarding its solubility:

  • Polarity: The presence of multiple methoxy groups may increase the compound's polarity, potentially enhancing its solubility in polar solvents such as water or alcohols.
  • Interactions: The piperazine ring can engage in hydrogen bonding, which can further facilitate solubility in polar solvents.
  • Thermodynamics: Solubility depends on thermodynamic factors, including lattice energy and solvation energy, which must be evaluated with particular solvents.
  • Contextual Solubility: Its solubility may vary greatly in organic solvents (like DMSO or ethanol) compared to aqueous environments.

Often, researchers and chemists must perform specific solubility tests to ascertain the precise behavior of such compounds in various solutions. Understanding these dynamics is not just academic; it plays a critical role in the compound's use in pharmaceuticals, where solubility can dictate bioavailability and effectiveness.

In conclusion, while the solubility of [4-(4-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone presents intriguing possibilities, further studies are necessary to clarify its profile in different solvents.

Interesting facts

Interesting Facts about [4-(4-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone

This compound is a fascinating example of a piperazine derivative that has attracted considerable interest in medicinal chemistry. Here are some intriguing aspects:

  • Biological Activity: The compound has shown potential pharmacological effects, making it a subject of investigation in the development of new therapeutic agents. Many piperazine derivatives are known for their neuroactive properties, which may open doors to treatments for various neurological disorders.
  • Structural Complexity: The molecule's structure features multiple methoxy groups on the phenyl rings, which can significantly influence its reactivity and interaction with biological targets. These substitutions are often associated with enhanced lipophilicity and improved bioavailability.
  • Receptor Interaction: Compounds such as this often interact with neurotransmitter receptors, particularly serotonin and dopamine receptors. This interaction can lead to various effects on mood and cognition, thus underlining its importance in psychopharmacology.
  • Synthetic Routes: The synthesis of this compound involves advanced organic chemistry techniques, illustrating the creativity and skill required in the laboratory to manipulate complex molecular architectures.

As a chemistry student or researcher, one might say, "Understanding this compound can give us insights into designing better pharmaceuticals that can target neurological pathways more effectively." The exploration of such compounds is vital as we strive to address the pressing needs of modern medicine, making the continued research on such derivatives crucial.

Synonyms
17766-70-0
BRN 1605756
KETONE, 4-(p-METHOXYPHENYL)PIPERAZINYL 3,4,5-TRIMETHOXYPHENYL
1-(p-Methoxyphenyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
4-(p-Methoxyphenyl)piperazinyl 3,4,5-trimethoxyphenyl ketone
DTXSID90170362
Piperazine, 1-(p-methoxyphenyl)-4-(3,4,5-trimethoxybenzoyl)-
5-23-02-00026 (Beilstein Handbook Reference)
DTXCID2092853
[4-(4-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
4-(p-Methoxyphenyl)-1-piperazinyl(3,4,5-trimethoxyphenyl) ketone
STK227851
AKOS001136260
CCG-329458
Z27906582
[4-(4-methoxyphenyl)piperazin-1-yl](3,4,5-trimethoxyphenyl)methanone