Skip to main content

1-(3,4,5-Trimethoxyphenyl)-4-(4-methylpiperazin-1-yl)butan-1-one dihydrochloride

ADVERTISEMENT
Identification
Molecular formula
C16H26N2O4.2HCl
CAS number
172192-28-8
IUPAC name
4-(4-methylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)butan-1-one;dihydrochloride
State
State

At room temperature, the compound is in a solid state. It is stable under normal conditions but should be stored in a cool, dry place to prevent degradation. The solid form could be utilized in various formulations, typically in research and experimental settings.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
400.33g/mol
Molar mass
400.3270g/mol
Density
1.2000g/cm3
Appearence

The compound is typically found as a white to off-white crystalline powder. The compound's crystalline nature gives it a defined solid structure, often appearing as fine crystals or crystalline lumps.

Comment on solubility

Solubility of 4-(4-methylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)butan-1-one; dihydrochloride

The solubility of the compound 4-(4-methylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)butan-1-one; dihydrochloride can be characterized as follows:

  • Water Solubility: This compound exhibits good solubility in aqueous solutions due to the presence of the dihydrochloride form, which greatly enhances its hydrophilicity.
  • Solvent Dependency: While it is soluble in water, the solubility may vary in organic solvents; it tends to be less soluble in non-polar solvents such as hexane or toluene.
  • Effect of Temperature: An increase in temperature generally leads to increased solubility in water, making it beneficial for laboratory preparations.
  • pH Influence: Solubility can also be pH-dependent. In acidic conditions, where the dihydrochloride can remain protonated, solubility may be further enhanced.

In summary, the dihydrochloride form of this compound not only improves its water solubility but also makes it a versatile molecule for various applications, especially in aqueous environments.

Interesting facts

Interesting Facts about 4-(4-methylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)butan-1-one; dihydrochloride

This compound, often referred to in the realm of medicinal chemistry, boasts fascinating attributes that have garnered attention in pharmaceutical research. As a dihydrochloride salt, it demonstrates enhanced solubility, which is a key characteristic for many drug compounds.

Structural Significance

The structure of this compound includes:

  • Piperazine moiety: This six-membered ring adds to the compound's pharmacological activity.
  • Trimethoxyphenyl group: Known for its role in enhancing biological effectiveness due to electron-donating groups.
  • Butan-1-one chain: This contributes to the hydrophobic characteristics, influencing the overall interaction with biological membranes.

Biological Relevance

One of the most compelling aspects of 4-(4-methylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)butan-1-one is its potential in treating various disorders. Researchers continue to investigate its role in:

  • Neuropharmacology: The piperazine ring is a common motif in many neuroactive drugs.
  • Anti-depressant activities: Initial studies suggest efficacy in mood regulation.
  • Potential in pain management: Relevant for understanding its analgesic properties.

Intellectual Curiosity

For budding chemists and students, this compound serves as a rich subject for study due to its:

  • Multifaceted structure: A perfect example for illustrating structure-activity relationships (SAR).
  • Therapeutic applications: Encompasses a wide range of biomedical relevance.
  • Interdisciplinary nature: Connects organic chemistry, pharmacology, and medicinal development.

In conclusion, 4-(4-methylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)butan-1-one; dihydrochloride is not just a chemical compound; it is a promising agent in the quest for novel therapeutics, embodying the intricate link between structure and function that is at the heart of chemical research.

Synonyms
16785-18-5
BUTYROPHENONE, 4-(4-METHYLPIPERAZINYL)-3',4',5'-TRIMETHOXY-, DIHYDROCHLORIDE
4-(4-Methylpiperazinyl)-3',4',5'-trimethoxybutyrophenone dihydrochloride
DTXSID30168405
1-Methyl-4-(3-(3,4,5-trimethoxybenzoyl)propyl)piperazine dihydrochloride
Piperazine, 1-methyl-4-(3-(3,4,5-trimethoxybenzoyl)propyl)-, dihydrochloride
DTXCID9090896