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Flunarizine dihydrochloride

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Identification
Molecular formula
C26H28N2O3·2HCl
CAS number
30484-77-6
IUPAC name
4-(4-phenylpiperazin-1-yl)butyl 3,4,5-trimethoxybenzoate;dihydrochloride
State
State

At room temperature, Flunarizine dihydrochloride is in a solid state.

Melting point (Celsius)
238.00
Melting point (Kelvin)
511.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
481.44g/mol
Molar mass
481.4390g/mol
Density
1.2500g/cm3
Appearence

Flunarizine dihydrochloride appears as a white to off-white crystalline powder. The compound is usually odorless and has a bitter taste.

Comment on solubility

Solubility Analysis

The solubility of 4-(4-phenylpiperazin-1-yl)butyl 3,4,5-trimethoxybenzoate; dihydrochloride can be intriguing due to its complex structure. As a dihydrochloride salt, it is expected to exhibit enhanced solubility in polar solvents due to the presence of ionic interactions. Here are some key points regarding its solubility:

  • Polar Solvents: Generally, compounds like this dihydrochloride salt are soluble in water and other polar solvents, owing to the ionic functional groups.
  • Non-Polar Solvents: Its solubility in non-polar solvents is likely to be quite low, as such compounds tend to favor interactions with polar molecules.
  • pH Sensitivity: The solubility may also be affected by pH changes in the environment, where the compound might dissociate into its ionic form more readily in acid conditions.

In summary, while precise solubility values can depend on various conditions such as temperature and the presence of other solutes, this compound is anticipated to show good solubility in aqueous solutions, making it favorable for pharmaceutical applications where solubility is crucial. As with many chemical compounds, understanding the solubility profile is essential for predicting its behavior in biological systems.

Interesting facts

Interesting Facts about 4-(4-phenylpiperazin-1-yl)butyl 3,4,5-trimethoxybenzoate; dihydrochloride

This complex compound presents a fascinating blend of chemistry and potential therapeutic applications. Here's what you should know:

  • Structural Diversity: The compound consists of a piperazine moiety, which is known for its structural versatility, combined with a benzoate ester. This unique structure allows it to interact with various biological targets.
  • Potential Therapeutic Role: Compounds like this one have garnered attention in pharmacology as potential candidates for the development of antidepressants and anxiolytics. The piperazine structure, in particular, has been linked to modulatory effects on neurotransmitter systems.
  • Modifications Matter: The presence of methoxy groups on the benzoate ring may enhance the lipophilicity of the compound, impacting its ability to cross biological membranes. This can significantly influence its bioavailability and efficacy.
  • Synthetic Challenges: The synthesis of such multi-functional compounds can pose challenges, requiring careful planning and execution to maintain desired purity and yield. The intricate synthesis can be a rewarding experience for students looking to apply their theoretical knowledge in practical settings.
  • Application in Research: This compound can serve as a valuable tool in understanding various neurological pathways, potentially leading to breakthroughs in treating mood disorders.

In summary, 4-(4-phenylpiperazin-1-yl)butyl 3,4,5-trimethoxybenzoate; dihydrochloride exemplifies the intersection of complex organic chemistry with the vibrant world of medicinal research. Its multifaceted nature makes it a captivating subject for both chemists and pharmacologists.

Synonyms
MA 568
5914-66-9
Benzoic acid, 3,4,5-trimethoxy-, 4-(4-phenyl-1-piperazinyl)butyl ester, dihydrochloride
DTXSID10207881
4-(4-Phenyl-1-piperazinyl)butyl 3,4,5-trimethoxybenzoate dihydrochloride
3,4,5-Trimethoxybenzoic acid 4-(4-phenyl-1-piperazinyl)butyl ester dihydrochloride
DTXCID60130372