Skip to main content

DAS181

ADVERTISEMENT
Identification
Molecular formula
C25H25FN6
CAS number
163942-83-4
IUPAC name
4-[5-(4-fluorophenyl)-3-(4-piperidyl)imidazol-4-yl]pyrimidin-2-amine
State
State

In its pure form, DAS181 is a solid at room temperature. It typically exists in the form of a powder and is stable under normal environmental conditions.

Melting point (Celsius)
300.00
Melting point (Kelvin)
573.20
Boiling point (Celsius)
677.30
Boiling point (Kelvin)
950.50
General information
Molecular weight
485.54g/mol
Molar mass
485.5420g/mol
Density
1.3400g/cm3
Appearence

The compound appears as a white to off-white solid powder. It has a crystalline form, and may be observed as being odorless.

Comment on solubility

Solubility Characteristics

The compound 4-[5-(4-fluorophenyl)-3-(4-piperidyl)imidazol-4-yl]pyrimidin-2-amine (C25H25FN6) displays unique solubility traits that are critical for its applications and effectiveness. Understanding its solubility is crucial for pharmaceutical development and formulation.

Solubility Insights

  • Solvent Interactions: This compound is likely to exhibit variable solubility in different solvents due to its complex structure, which contains multiple functional groups that can engage in hydrogen bonding or dipole interactions.
  • Aqueous Solubility: Given its substantial aromatic and piperidine entities, the solubility in water may be moderate, possibly requiring enhancement strategies for optimal bioavailability.
  • Organic Solvents: It should be more soluble in organic solvents like DMSO (Dimethyl sulfoxide) or ethanol owing to its hydrophobic regions.
  • pH Dependence: The solubility may significantly change with pH adjustments; basic conditions could enhance solubility for ionizable groups present in the compound.

In summary, while the compound C25H25FN6 is expected to have certain solubility challenges in aqueous environments, its behavior in organic solvents and under varying pH conditions provides intriguing prospects for further exploration and modification.

Interesting facts

Interesting Facts about 4-[5-(4-fluorophenyl)-3-(4-piperidyl)imidazol-4-yl]pyrimidin-2-amine

This compound is a fascinating member of the chemical world, primarily due to its complex structure and potential applications in medicinal chemistry. Here are some striking points of interest:

  • Multi-Functional Molecule: The presence of both imidazole and pyrimidine moieties indicates that this compound can interact with multiple biological targets, making it a candidate for drug development.
  • Pharmacological Potential: The structural elements of this compound suggest it may have effects on the central nervous system. Compounds that include piperidine are often associated with neuropharmacological activity.
  • Fluorine's Role: The incorporation of a fluorine atom can enhance the metabolic stability of the compound, potentially increasing the efficacy of the resultant drug.
  • Research Applications: Due to its complex structure, this compound is likely to be of interest in studies focusing on enzyme inhibition or receptor binding, particularly in the context of cancer research or neurobiology.
  • Chemical Synthesis: The synthesis of such a compound may involve various advanced techniques including but not limited to, *cross-coupling reactions*, which are staples in organic chemistry.

As a scientist or student delving into the field of chemistry, this compound serves as an excellent example of how small variations in molecular structure can lead to significant changes in biological activity. It beautifully illustrates the intricate dance between chemistry and biology, inviting investigations into its potential as a therapeutic agent.

"The beauty of chemistry lies in the details—each atom and bond tells a story."

Synonyms
SB220025
165806-53-1
sb 220025
3erk
SB-220025
4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine
CHEBI:82713
4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE
MX95H97VRG
CHEMBL274064
4-[5-(4-fluorophenyl)-3-(4-piperidyl)imidazol-4-yl]pyrimidin-2-amine
4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]pyrimidin-2-amine
2-Pyrimidinamine, 4-(4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl)-
4-(4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl)-2-pyrimidinamine
4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-pyrimidinamine
1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-(amino)-4-pyrimidinyl)imidazole
1-(4-piperidinyl)-4-(4-fluorophenyl)-5-[2-(amino)-4-pyrimidinyl]imidazole
4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine
VSPFURGQAYMVAN-UHFFFAOYSA-N
Kinome_3166
1bl7
UNII-MX95H97VRG
SCHEMBL173441
GTPL6038
BDBM15239
HMS3229M12
MFCD02179213
NSC756416
NSC756417
AKOS017344571
CCG-206879
DB04338
FF99692
NSC-756416
NSC-756417
SDCCGGSK-0000296.P001
SDCCGGSK-0000296.P002
SDCCGSBI-0086783.P005
NCGC00165900-01
NCGC00165900-02
NCGC00165900-03
DB-138083
HY-112291
CS-0044744
NS00068128
AB01092383-01
AB01092383-02
EN300-6488091
Q27088707
Z2037280271
1-(4-piperidinyl)-4-(4-fluorophenyl)-5-[2-(amino)-4-pyrimdinyl]imidazole
1-(4-piperidinyl)-4-(4-fluorophenyl)-5-[2-(amino)-4pyrimidinyl]imidazole
4-[5-(4-fluorophenyl)-3-(piperidin-4-yl)imidazol-4-yl]pyrimidin-2-amine
5-(2-amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole
5-(2-amino-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole
4-[4-(4-fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidin-2-amine
827-712-1