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Clomipramine

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Identification
Molecular formula
C19H23ClN2S
CAS number
303-49-1
IUPAC name
4-(5-chloro-2-methylsulfanyl-phenyl)-N,N-dimethyl-4-phenyl-but-3-en-1-amine
State
State

At room temperature, clomipramine is in a solid state in the form of a crystalline powder.

Melting point (Celsius)
186.00
Melting point (Kelvin)
459.15
Boiling point (Celsius)
432.50
Boiling point (Kelvin)
705.50
General information
Molecular weight
314.87g/mol
Molar mass
314.8650g/mol
Density
1.1500g/cm3
Appearence

Clomipramine is a white to off-white crystalline powder. It is practically insoluble in water, but soluble in organic solvents such as ethanol and chloroform.

Comment on solubility

Solubility of 4-(5-chloro-2-methylsulfanyl-phenyl)-N,N-dimethyl-4-phenyl-but-3-en-1-amine

The solubility of 4-(5-chloro-2-methylsulfanyl-phenyl)-N,N-dimethyl-4-phenyl-but-3-en-1-amine in various solvents can provide insight into its potential applications and behavior in chemical environments. This compound primarily exhibits moderate to low solubility in polar solvents, which may include:

  • Water: Generally, it is poorly soluble due to its hydrophobic characteristics.
  • Organic solvents: However, it may dissolve better in organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO).
  • Aromatic solvents: Compounds with aromatic characteristics often show better solubility in non-polar or slightly polar environments.

Factors influencing the solubility include:

  • **Chemical structure:** The presence of both hydrophobic and hydrophilic groups can complicate solubility behavior.
  • **Temperature:** Increased temperature typically enhances solubility in many solvents.
  • **pH levels:** The ionization state of the amine group in different pH values can affect solubility.

It’s essential to conduct detailed solubility tests to determine the optimal conditions for dissolving this compound. As noted in literature, “Understanding solubility is pivotal for formulating robust compounds.” When planning experiments, consider these solubility characteristics to ensure proper handling and application.

Interesting facts

Interesting Facts About 4-(5-Chloro-2-methylsulfanyl-phenyl)-N,N-dimethyl-4-phenyl-but-3-en-1-amine

This intriguing compound, often considered for its potential applications in medicinal chemistry, possesses a unique structural arrangement that contributes to its fascinating chemical behavior. Here are some notable aspects:

  • Structural Diversity: The presence of multiple functional groups, such as the methylsulfanyl and dimethylamine moieties, allows this compound to exhibit varying properties and reactivities, making it a candidate for further exploration in drug development.
  • Pharmacological Potential: Compounds of this nature have been studied for their ability to interact with biological targets, indicating potential therapeutic applications in treating various conditions, including neurological disorders.
  • Chirality and Isomerism: The geometric configuration of the but-3-en-1-amine portion introduces the possibility of isomeric forms. This aspect is crucial in understanding the compound's activity, as different isomers may have different biological effects.
  • Environmental Impact: Understanding the environmental behavior of such compounds is essential, especially concerning their degradation pathways and toxicological profiles, to ensure safety in usage.

In the world of organic synthesis, the exploration of compounds like this one can lead to breakthroughs not only in medicinal chemistry but also in various fields of materials science due to their unique properties. As a budding chemist or researcher, diving into the complexities of such compounds can spark creativity and drive innovation!

“In chemistry, as in life, the simplest things are often the most profound.”