Interesting facts
Interesting Facts about 4-[5-(p-tolyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
This fascinating compound, known for its intricate structure, belongs to the class of sulfonamides, which are crucial in medicinal chemistry. Here are some notable points about its significance:
- Pharmaceutical Potential: Sulfonamides, including this compound, have shown promise as antibacterial agents. Their ability to inhibit bacterial growth by interfering with folic acid synthesis makes them invaluable in drug development.
- Trifluoromethyl Group: The presence of the trifluoromethyl group enhances the lipophilicity of the compound, potentially affecting its bioavailability and pharmacokinetics.
- Pyrazole Motif: The pyrazole ring is noteworthy for its biological activity, and compounds featuring this functional group are often involved in anti-inflammatory and antitumor activities.
- p-Tolyl Substitution: The p-tolyl group contributes to the chemical's reactivity and stability, showcasing the importance of substituents in modulating the properties of complex organic molecules.
This compound exemplifies how modifying a molecular framework can lead to diverse biological properties. The ongoing research into its applications in various fields, particularly in developing new antibiotics and therapeutic agents, makes it a compound of great interest. As a chemistry student or scientist, one might say, "Understanding the interaction of such compounds with biological targets is key to innovating new treatments."
Overall, 4-[5-(p-tolyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide represents a harmonious blend of chemistry and biology, paving the way for advancements in therapeutic interventions.
Synonyms
celecoxib
169590-42-5
Celebrex
Celebra
Onsenal
Celecox
Celocoxib
184007-95-2
Xilebao
4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
SC-58635
YM177
4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE
SC 58635
YM 177
HSDB 7038
MFCD00941298
Celecoxibum
p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide
UNII-JCX84Q7J1L
194044-54-7
DFN15
JCX84Q7J1L
4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
NSC-719627
NSC-758624
SC58635
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide
ELYXYB
CCRIS 9330
DFN-15
DTXSID0022777
CHEBI:41423
Celecoxib (GMP Like)
YM-177
CHEMBL118
4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonami de
DTXCID502777
CONSENSI COMPONENT CELECOXIB
benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
NSC719627
NSC 719627
NSC 758624
Celecoxib [USAN]
NCGC00091455-01
4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
CELECOXIB (MART.)
CELECOXIB [MART.]
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Benzenesulfonamide,4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
CELECOXIB (USP-RS)
CELECOXIB [USP-RS]
CELECOXIB (EP MONOGRAPH)
CELECOXIB [EP MONOGRAPH]
CELECOXIB (USP MONOGRAPH)
CELECOXIB [USP MONOGRAPH]
Solexa
Benzenesulfonamide, 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)-
Celebrex (TN)
SMR000550473
CAS-169590-42-5
SR-01000837528
Celecixib
Celecoxib [USAN:INN:BAN]
Celecoxib?
Generic Drug
ELYXYB-celecoxib
TPI-336
Celecoxib 50 mg
Celecoxib (GMP)
Onsenal (TN)
AI-525
Celecoxib 100 mg
Celecoxib 200 mg
Celecoxib 400 mg
CEP-33222
CELEBCOXIB
Celecoxib (Standard)
Spectrum_000432
1oq5
CELECOXIB [INN]
CELECOXIB [JAN]
CELECOXIB [MI]
CELECOXIB [HSDB]
Spectrum2_001576
Spectrum3_001996
Spectrum4_000182
Spectrum5_001324
CELECOXIB [VANDF]
CELECOXIB [WHO-DD]
cid_2662
SCHEMBL3708
BSPBio_003596
CELECOXIB [EMA EPAR]
KBioGR_000723
KBioGR_002351
KBioSS_000912
KBioSS_002354
MLS001165684
MLS001195656
MLS001304708
MLS006011862
BIDD:GT0408
DivK1c_000893
SPECTRUM1503678
Celecoxib - Bio-X trade mark
SPBio_001512
Celecoxib (JP18/USP/INN)
GTPL2892
CELECOXIB [ORANGE BOOK]
BDBM11639
HMS502M15
KBio1_000893
KBio2_000912
KBio2_002351
KBio2_003480
KBio2_004919
KBio2_006048
KBio2_007487
KBio3_002830
KBio3_003037
EX-A175
L01XX33
M01AH01
cMAP_000027
NINDS_000893
BCPP000290
HMS1922G14
HMS2089L18
HMS2093I07
HMS2234N18
HMS3259L08
HMS3261A14
HMS3373A09
HMS3654H09
HMS3715F11
HMS3867I03
HMS3884M07
HY-14398GL
Pharmakon1600-01503678
ALBB-033772
BCP02156
UWA68620
UWA68621
Tox21_111135
Tox21_201964
Tox21_300599
Tox21_500406
US8741944, Comparative Compound
4-[5-(p-tolyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
BBL029086
CCG-39354
HY-14398G
HY-14398R
NSC758624
s1261
STL373576
Celecoxib 1.0 mg/ml in Acetonitrile
AKOS015842517
CELECOXIB COMPONENT OF CONSENSI
Tox21_111135_1
AC-4228
BCP9000507
CS-0570
DB00482
FC11300
KS-1041
NC00708
SB19318
IDI1_000893
NCGC00091455-02
NCGC00091455-03
NCGC00091455-04
NCGC00091455-05
NCGC00091455-06
NCGC00091455-07
NCGC00091455-08
NCGC00091455-09
NCGC00091455-13
NCGC00254540-01
NCGC00259513-01
NCGC00261091-01
BC164295
BP-30217
HY-14398
NCI60_041049
PHA-00846533
SY064976
SBI-0051875.P002
CJ-016377
CP-598107
UNM-0000305813
C2816
CS-0901612
NS00002556
SW199611-3
PF-00345549
C07589
D00567
EN300-119504
AB00052396-07
AB00052396-08
AB00052396-09
AB00052396_10
AB00052396_11
Q408801
SR-01000837528-2
SR-01000837528-3
BRD-K02637541-001-02-4
BRD-K02637541-001-06-5
BRD-K02637541-001-17-2
BRD-K02637541-001-18-0
Z1258938406
Celecoxib, European Pharmacopoeia (EP) Reference Standard
Celecoxib, United States Pharmacopeia (USP) Reference Standard
4-[5-(p-Tolyl)-3-(trifluoromethyl)-1-pyrazolyl]benzenesulfonamide
4-(5-p-tolyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-pyrazol-1-yl]benzenesulfonamide
5-(4-Methylphenyl)-1-(4-sulfamoylphenyl)-3-(trifluoromethyl)pyrazole
Celecoxib, Pharmaceutical Secondary Standard; Certified Reference Material
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyazol-1-yl]benezenesulfonamide
4-[5-(4-Methylphenyl)-3-trifluoromethyl)-1H-pyrazol-yl]benzenesulfonamide;Celebra
4-[5-(4-Methylphenyl)-3-trifluoromethyl)-1H-pyrazol-yl]benzenesulfonamid e; Celebra;Celocoxib;SC 58635; SC-58635
Solubility of 4-[5-(p-tolyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
The solubility of the compound 4-[5-(p-tolyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide (C17H14F3N3O2S) is influenced by several factors, including its molecular structure, functional groups, and the solvent used for dissolution. Here are some key points regarding its solubility:
While specific solubility values are not universally available, laboratory assessment is often necessary to determine the solubility profile accurately. In general, careful consideration of the solvent type and conditions will provide insights into the dissolution behavior of this intriguing compound.