Celecoxib

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Identification

Molecular formula
C17H14F3N3O2S
CAS Number
169590-42-5
IUPAC Name
4-[5-(p-tolyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
Molecular Weight
381.37g/mol
Melting Point
(Celsius)
Boiling Point
(Celsius)
Density
1.4000g/cm3
Synonyms
celecoxib
Interesting facts

Interesting Facts about 4-[5-(p-tolyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide

This fascinating compound, known for its intricate structure, belongs to the class of sulfonamides, which are crucial in medicinal chemistry. Here are some notable points about its significance:

  • Pharmaceutical Potential: Sulfonamides, including this compound, have shown promise as antibacterial agents. Their ability to inhibit bacterial growth by interfering with folic acid synthesis makes them invaluable in drug development.
  • Trifluoromethyl Group: The presence of the trifluoromethyl group enhances the lipophilicity of the compound, potentially affecting its bioavailability and pharmacokinetics.
  • Pyrazole Motif: The pyrazole ring is noteworthy for its biological activity, and compounds featuring this functional group are often involved in anti-inflammatory and antitumor activities.
  • p-Tolyl Substitution: The p-tolyl group contributes to the chemical's reactivity and stability, showcasing the importance of substituents in modulating the properties of complex organic molecules.

This compound exemplifies how modifying a molecular framework can lead to diverse biological properties. The ongoing research into its applications in various fields, particularly in developing new antibiotics and therapeutic agents, makes it a compound of great interest. As a chemistry student or scientist, one might say, "Understanding the interaction of such compounds with biological targets is key to innovating new treatments."

Overall, 4-[5-(p-tolyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide represents a harmonious blend of chemistry and biology, paving the way for advancements in therapeutic interventions.

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