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4-[(6-Chloro-4-oxo-4H-chromene-2-carbonyl)amino]benzoic acid

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Identification
Molecular formula
C16H10ClNO4
CAS number
3671-88-3
IUPAC name
4-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]benzoic acid
State
State

At room temperature, this compound exists in a solid state. Due to its higher melting point, it remains stable and does not convert into liquid form under normal conditions.

Melting point (Celsius)
278.00
Melting point (Kelvin)
551.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
319.71g/mol
Molar mass
319.7090g/mol
Density
1.5300g/cm3
Appearence

The compound typically appears as a crystalline solid, generally existing in powder form. Depending on its purity and preparation process, the specific color might vary slightly, but it is usually off-white to light beige.

Comment on solubility

Solubility of 4-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]benzoic acid

The solubility of 4-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]benzoic acid in various solvents can be complex and depends significantly on its molecular structure. Here are some key insights:

  • Polar Solvents: This compound is expected to show moderate solubility in polar solvents such as water due to its carboxylic acid functional group. The -COOH group can engage in hydrogen bonding with water molecules, potentially increasing its solubility.
  • Nonpolar Solvents: Conversely, solubility in nonpolar solvents like hexane or toluene may be quite limited. The aromatic components and polar substituents create an unfavorable environment for dissolution in such solvents.
  • pH Sensitivity: The solubility can also be influenced by the pH of the solution. At higher pH levels, the carboxylic acid group may deprotonate, forming a negatively charged carboxylate ion which can lead to increased solubility.
  • Temperature Dependence: Temperature plays a pivotal role; generally, increased temperature can enhance solubility in most solvents, although this is compound-specific.

To summarize, the solubility of 4-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]benzoic acid is multidimensional, influenced by the nature of the solvent, temperature, and the pH of the solution. It illustrates the intricate balance of hydrophilicity and hydrophobicity in organic compounds. As noted, understanding its solubility profile is crucial for optimizing its applications in chemical processes and formulations.

Interesting facts

Interesting Facts about 4-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]benzoic Acid

4-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]benzoic acid is a captivating compound with significant implications in the field of medicinal chemistry and drug discovery. Here are some key insights that highlight its importance:

  • Structural Diversity: This compound exhibits a unique structural arrangement that combines a benzene ring with a chromene moiety. Such diverse structures can lead to varied biological activities, making them of particular interest in pharmacology.
  • Potential Antioxidant Activity: Compounds containing chromene cores are often explored for their antioxidant properties. This particular derivative might exhibit protective effects against oxidative stress-related disorders.
  • Role in Drug Design: The presence of the –COOH (carboxylic acid) functional group could enhance its solubility and bioavailability, playing a critical role in the design of effective therapeutic agents.
  • Biological Activity: Research is increasingly focusing on the biological activities of similar compounds, including anti-inflammatory and anticancer properties, making this compound a viable candidate for further exploration.

As you delve into the world of chemical compounds, remember that each unique structure tells a story of its potential applications. The ongoing research surrounding 4-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]benzoic acid may unveil groundbreaking discoveries in medicine and beyond.

Synonyms
27455-38-5
BENZOIC ACID, p-(6-CHLORO-4-OXO-4H-1-BENZOPYRAN-2-CARBOXAMIDO)-
BRN 1399762
p-(6-Chloro-4-oxo-4H-1-benzopyran-2-carboxamido)benzoic acid
DTXSID50181873