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Nabumetone

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Identification
Molecular formula
C15H16O2
CAS number
42924-53-8
IUPAC name
4-(6-methoxy-2-naphthyl)butan-2-one
State
State

Nabumetone is typically in a solid state at room temperature as a crystalline powder. It is utilized as a non-steroidal anti-inflammatory drug (NSAID) in its solid, formulated form.

Melting point (Celsius)
80.00
Melting point (Kelvin)
353.15
Boiling point (Celsius)
485.15
Boiling point (Kelvin)
758.30
General information
Molecular weight
228.28g/mol
Molar mass
228.2820g/mol
Density
1.1520g/cm3
Appearence

Nabumetone appears as a white to off-white crystalline powder. It is odorless or has a faint odor. The powder is typically used in pharmaceutical formulations.

Comment on solubility

Solubility of 4-(6-methoxy-2-naphthyl)butan-2-one

The solubility of the compound 4-(6-methoxy-2-naphthyl)butan-2-one, with the chemical formula C15H16O2, can be analyzed through several important factors:

  • Polarity: The presence of the methoxy group (-OCH3) suggests some polar characteristics, which may enhance the solubility in polar solvents.
  • Solvent Compatibility: This compound is likely to be more soluble in organic solvents such as ethanol, acetone, or dichloromethane compared to water, due to its hydrophobic naphthalene structure.
  • Functional Groups: The ketone group (C=O) may confer some degree of reactivity and could interact with other compounds, possibly affecting solubility.

In general, the solubility of 4-(6-methoxy-2-naphthyl)butan-2-one is expected to be:

  1. High in non-polar organic solvents
  2. Moderate in slightly polar solvents
  3. Low in water

As a general note, temperature and pressure can significantly influence solubility, so experimental determination under various conditions is advisable to obtain precise solubility data.

Interesting facts

Interesting Facts About 4-(6-Methoxy-2-naphthyl)butan-2-one

4-(6-Methoxy-2-naphthyl)butan-2-one, often referred to in the realm of organic chemistry as a member of the ketone family, is compelling for a variety of reasons. Here's a closer look at what makes this compound intriguing:

  • Structural Complexity: This compound features a unique combination of a butanone backbone and a substituted naphthalene ring, which contributes to its rich chemical properties and potential reactivity.
  • Pharmacological Potential: Research into similar naphthalene-based compounds has revealed that they may possess interesting biological activities. They are often explored for applications as antioxidants, anti-inflammatory agents, and even in the development of novel pharmaceuticals.
  • Functional Group Diversity: With the presence of both a ketone functional group and a methoxy substituent, this compound can participate in assorted reaction pathways, making it of interest in synthetic organic chemistry.
  • Use in Dyes and Pigments: Compounds with naphthalene structures are commonly used in dye production, showcasing various shades and hues, further underlining their economic significance and industrial application.
  • Historical Significance: Historically, naphthalene derivatives have contributed to advancements in chemical research and industry, paving the way for modern material science and organic synthesis techniques.

As noted by renowned chemists, “The complexity of organic compounds opens a multitude of doors for exploration.” This emphasizes the essence of studying compounds like 4-(6-methoxy-2-naphthyl)butan-2-one, where every structure tells a story waiting to be uncovered!

Synonyms
nabumetone
42924-53-8
Relafen
4-(6-methoxynaphthalen-2-yl)butan-2-one
Arthaxan
Nabumetona
Relifen
Relifex
4-(6-Methoxy-2-naphthyl)-2-butanone
Consolan
Balmox
Listran
nabumeton
Dolsinal
Flambate
Unimetone
Prodac
Nabumetonum
Nabumetonum [INN-Latin]
BRL-14777
Nabuser
4-(2-Methoxynaphthalen-6-yl)butan-2-one
4-(6-Methoxy-2-naphthalenyl)-2-butanone
BRL 14777
2-Butanone, 4-(6-methoxy-2-naphthalenyl)-
UNII-LW0TIW155Z
LW0TIW155Z
NSC-758623
BRN 2103472
CCRIS 8108
CHEBI:7443
MLS000069541
DTXSID4045472
BRL14777
Mebutan
MFCD00079518
Relif
SMR000058835
DTXCID2025472
NSC 758623
Nabumetone [USAN:USP:INN:BAN:JAN]
NCGC00016853-01
CAS-42924-53-8
Nabumetonum (INN-Latin)
NABUMETONE (MART.)
NABUMETONE [MART.]
NABUMETONE (USP-RS)
NABUMETONE [USP-RS]
NABUMETONE (EP MONOGRAPH)
NABUMETONE (USP IMPURITY)
NABUMETONE [EP MONOGRAPH]
NABUMETONE [USP IMPURITY]
NABUMETONE (USP MONOGRAPH)
NABUMETONE [USP MONOGRAPH]
Nabumetone (USAN:USP:INN:BAN:JAN)
SR-01000759138
Nabumentone
4-(6-Methoxy-2-naphthalenyl)-2-butanone;1-(2'-Methoxynaphth-6'-yl)butan-3-one
Nabumatone Form II
Relafen (TN)
Nabumetone 500 mg
Nabumetone 750 mg
Nabumetone (Standard)
RELAFEN DS
Nabumetone 1000 mg
Spectrum_001486
NABUMETONE [MI]
Opera_ID_765
NABUMETONE [INN]
NABUMETONE [JAN]
Prestwick0_000909
Prestwick1_000909
Prestwick2_000909
Prestwick3_000909
Spectrum2_001969
Spectrum4_000174
Spectrum5_001286
NABUMETONE [USAN]
NABUMETONE [VANDF]
cid_4409
SCHEMBL2256
CHEMBL1070
NABUMETONE [WHO-DD]
BSPBio_000758
KBioGR_000687
KBioSS_001966
MLS001076325
BIDD:GT0104
DivK1c_000850
SPECTRUM1503650
SPBio_002097
SPBio_002957
Nabumetone, analytical standard
BPBio1_000834
GTPL7245
Nabumetone (JP17/USP/INN)
Nabumetone - Bio-X trade mark
NABUMETONE [ORANGE BOOK]
BDBM40128
HMS502K12
HY-B0559R
KBio1_000850
KBio2_001966
KBio2_004534
KBio2_007102
M01AX01
NINDS_000850
HMS1570F20
HMS1922G10
HMS2090D13
HMS2093I05
HMS2097F20
HMS2230H12
HMS3259I16
HMS3652M04
HMS3714F20
HMS3885A22
Pharmakon1600-01503650
BCP12152
HY-B0559
Tox21_110647
CCG-39507
NSC758623
s4051
AKOS009529199
Tox21_110647_1
4-(6-methoxy-2-naphthyl)butan-2-one
DB00461
FN26115
KS-1371
NC00579
IDI1_000850
NCGC00016853-02
NCGC00016853-03
NCGC00016853-06
NCGC00016853-13
NCGC00095063-01
NCGC00095063-02
AC-19025
BN166181
SBI-0051869.P002
AB00052392
NS00003590
SW197312-3
D00425
L10109
AB00052392-13
AB00052392_14
AB00052392_15
EN300-1853581
Q425207
SR-01000759138-2
SR-01000759138-3
BRD-K65146499-001-04-8
BRD-K65146499-001-14-7
BRD-K65146499-001-26-1
BRD-K65146499-001-27-9
Nabumetone, British Pharmacopoeia (BP) Reference Standard
Nabumetone, European Pharmacopoeia (EP) Reference Standard
Nabumetone, United States Pharmacopeia (USP) Reference Standard