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1-(4-Fluorophenyl)-4-(7-azaspiro[4.5]decan-7-yl)butan-1-one

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Identification
Molecular formula
C19H26FNO
CAS number
206361-99-1
IUPAC name
4-(7-azaspiro[4.5]decan-7-yl)-1-(4-fluorophenyl)butan-1-one
State
State

At room temperature, this compound exists as a crystalline solid.

Melting point (Celsius)
37.80
Melting point (Kelvin)
310.80
Boiling point (Celsius)
445.60
Boiling point (Kelvin)
718.80
General information
Molecular weight
305.42g/mol
Molar mass
305.4220g/mol
Density
1.2230g/cm3
Appearence

The compound is generally described as a white to off-white crystalline powder.

Comment on solubility

Solubility of 4-(7-azaspiro[4.5]decan-7-yl)-1-(4-fluorophenyl)butan-1-one

The solubility of 4-(7-azaspiro[4.5]decan-7-yl)-1-(4-fluorophenyl)butan-1-one can be influenced by various factors, including polarity, temperature, and the nature of the solvent. Understanding these factors can aid in predicting its behavior in different environments.

Factors Affecting Solubility:

  • Polarity: The presence of both polar and non-polar functional groups suggests that this compound may exhibit a dual nature in regards to solubility.
  • Hydrogen Bonding: Functional groups capable of forming hydrogen bonds can significantly improve solubility in polar solvents such as water.
  • Temperature: Increased temperature generally enhances solubility for many organic compounds, allowing greater interaction between solute and solvent.

As a general rule:

  • Highly polar compounds tend to be soluble in polar solvents.
  • Non-polar compounds usually dissolve better in non-polar solvents.

In the case of this compound, it is likely to exhibit better solubility in organic solvents like ethanol or dichloromethane compared to water, due to its overall structure. Furthermore, fluorine substitutions typically increase solubility in certain organic solvents, thus enhancing its potential use in various applications.

Always remember, “The solvent is just as important as the solute!”

Interesting facts

Interesting Facts about 4-(7-azaspiro[4.5]decan-7-yl)-1-(4-fluorophenyl)butan-1-one

4-(7-azaspiro[4.5]decan-7-yl)-1-(4-fluorophenyl)butan-1-one is a fascinating compound that exemplifies the intricate structures and diverse functionalities found in organic chemistry. Here are some noteworthy aspects of this compound:

  • Structural Complexity: This compound features a spirocyclic structure, which is indicative of its unique three-dimensional arrangement. The presence of the azaspiro ring contributes to its conformational diversity, enabling potential interactions with biological targets.
  • Pharmacological Potential: Compounds with similar structural motifs have been explored in medicinal chemistry for their potential as therapeutic agents. The presence of a fluorine atom in its structure often enhances the metabolic stability and bioactivity of drugs.
  • Functional Group Interaction: The butanone side chain can participate in various reactions, serving as a versatile platform for further chemical modifications. This opens doors for the synthesis of a broader array of derivatives with potentially novel properties.
  • Applications in Research: Researchers are keen on studying compounds like this one for their applications in fields such as neuropharmacology, due to the presence of azaspiro structures that may interact with neurotransmitter pathways.

As chemists delve into the properties and reactivities of compounds like 4-(7-azaspiro[4.5]decan-7-yl)-1-(4-fluorophenyl)butan-1-one, the potential for discovery is vast and exciting. This compound serves as a prime example of how intricate molecular design can lead to promising applications in science and medicine.

Synonyms
BRN 1430820
BUTYROPHENONE, 4-(2-AZASPIRO(4.5)DEC-2-YL)-4'-FLUORO-
4-(2-Azaspiro(4.5)dec-2-yl)-4'-fluoro-butyrophenone
1093-22-7
DTXSID20148872
5-20-04-00402 (Beilstein Handbook Reference)
DTXCID7071363