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Chlorpheniramine

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Identification
Molecular formula
C18H20ClN3O
CAS number
132-22-9
IUPAC name
4-[(7-chloro-4-quinolyl)amino]-2-(pyrrolidin-1-ylmethyl)phenol
State
State

Chlorpheniramine is generally in the form of a solid crystalline powder at room temperature. This solid state is typical for many pharmaceuticals, allowing it to be easily processed into tablets, capsules, or other dosage forms.

Melting point (Celsius)
130.00
Melting point (Kelvin)
403.15
Boiling point (Celsius)
531.30
Boiling point (Kelvin)
804.40
General information
Molecular weight
320.84g/mol
Molar mass
320.8260g/mol
Density
1.2900g/cm3
Appearence

Chlorpheniramine is typically found as a white or slightly yellow crystalline powder. It can also appear as crystals, depending on the form and purity. The powder is odorless, making it suitable for use in formulations where scent is a concern. Its crystalline nature allows for easy blending into various pharmaceutical products.

Comment on solubility

Solubility of 4-[(7-chloro-4-quinolyl)amino]-2-(pyrrolidin-1-ylmethyl)phenol (C18H20ClN3O)

The solubility of 4-[(7-chloro-4-quinolyl)amino]-2-(pyrrolidin-1-ylmethyl)phenol can vary significantly depending on the solvent used and the environmental conditions. Here are some key considerations regarding its solubility:

  • Polarity: The presence of polar groups such as amino and hydroxyl can enhance solubility in polar solvents like water.
  • Hydrophobic Interactions: The quinoline moiety exerts hydrophobic characteristics, which may reduce solubility in highly polar solvents.
  • Temperature Dependency: As is common with many organic compounds, increased temperature often leads to higher solubility.
  • pH Sensitivity: The solubility might also be affected by the pH of the solution, particularly if the compound can exist in protonated or deprotonated forms.

As a result, understanding the solubility of this particular compound requires a nuanced approach, often necessitating experimental data to confirm solubility in specific solvents under varied conditions. It’s important to note that the solubility profile can play a crucial role in the compound's bioavailability when considering pharmacological applications.

In summary, the solubility characteristics are multifaceted and can be influenced by various factors, making it essential to conduct thorough investigations tailored to specific applications.

Interesting facts

Interesting Facts about 4-[(7-chloro-4-quinolyl)amino]-2-(pyrrolidin-1-ylmethyl)phenol

This compound, with its complex structure, presents a fascinating blend of chemical properties and potential applications. Let's dive into what makes this compound intriguing:

  • Pharmaceutical Relevance: This compound is a derivative of quinoline and showcases the importance of heterocyclic chemistry in drug development, as many therapeutics are designed with similar frameworks.
  • Biological Activities: Compounds like this one are often explored for their biological activities, including antibacterial and antimalarial properties, making them candidates for pharmaceutical development.
  • Chloro Group Influence: The presence of the chloro substituent can significantly enhance the compound's reactivity and biological interactions, often improving its efficacy in clinical settings.
  • Pyrrolidine Integration: The pyrrolidine moiety is known for its ability to act as a versatile building block in organic synthesis, contributing to the compound’s pharmacological potential.
  • Structure-Activity Relationship (SAR): Understanding the SAR of this compound can lead to the development of even more potent derivatives by altering various groups around the quinoline core.

In summary, 4-[(7-chloro-4-quinolyl)amino]-2-(pyrrolidin-1-ylmethyl)phenol is not just a chemical entity; it embodies the intricate relationship between structure and function in medicinal chemistry. As researchers continue to explore its capabilities, the compound stands as a testament to the power of molecular design in creating effective therapeutics.

Synonyms
Amopyroquine
550-81-2
Amopyroquin
Amopyrochinum
Amopyroquina
Amopyroquine [INN]
Amopyroquinum
amopiroquina
PAM-780
UNII-SV6L22Y9QF
Amopyroquinum [INN-Latin]
Amopyroquina [INN-Spanish]
SV6L22Y9QF
4-((7-Chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-o-cresol
DTXSID50203544
4-(7-Chlor-4-chinolylamino)-2-(1-pyrrolidinylmethyl)phenol
Amopyroquinum (INN-Latin)
Amopyroquina (INN-Spanish)
4-[(7-Chloro-4-quinolyl)amino]-.alpha.-1-pyrrolidinyl-o-cresol
o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-
Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-(1-pyrrolidinylmethyl)-
4-[(7-Chloro-4-quinolyl)amino]-alpha-1-pyrrolidinyl-o-cresol
DTXCID80126035
PAM 780
ynwcucsdumvjkr-uhfffaoysa-n
4-[(7-chloroquinolin-4-yl)amino]-2-(pyrrolidin-1-ylmethyl)phenol
Amopyroquin; PAM-780; Propoquin
4-[(7-Chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)phenol
SCHEMBL249505
CHEMBL1213257
AKOS030239783
FA17882
NS00093638
Q27289420
4-[(7-Chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)phenol #
4-[(7-Chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)phenol;4-[(7-Chloro-4-quinolyl)amino]-?-1-pyrrolidinyl-o-cresol