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Budesonide

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Identification
Molecular formula
C25H34O6
CAS number
51333-22-3
IUPAC name
4-[[(8R,9S,13S,14S,16R,17R)-17-(3-carboxypropanoyloxy)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]oxy]-4-oxo-butanoic acid
State
State

At room temperature, Budesonide is a solid. It is typically found in a crystalline powder form.

Melting point (Celsius)
221.00
Melting point (Kelvin)
494.00
Boiling point (Celsius)
150.00
Boiling point (Kelvin)
423.00
General information
Molecular weight
430.54g/mol
Molar mass
430.5360g/mol
Density
1.1308g/cm3
Appearence

The compound Budesonide is typically characterized by its white to off-white crystalline powder form. It is practically insoluble in water, making it appear relatively solid and opaque when observed in its typical commercial form.

Comment on solubility

Solubility of 4-[[(8R,9S,13S,14S,16R,17R)-17-(3-carboxypropanoyloxy)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]oxy]-4-oxo-butanoic acid

The solubility of this complex compound, known as 4-[[(8R,9S,13S,14S,16R,17R)-17-(3-carboxypropanoyloxy)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]oxy]-4-oxo-butanoic acid, can be influenced by several factors:

  • Polarity: The presence of multiple hydroxyl (-OH) and carboxyl (-COOH) groups indicates a likelihood of high polarity, which typically enhances solubility in polar solvents like water.
  • Hydrogen bonding: The functional groups can engage in strong hydrogen bonding with solvents, thus facilitating solubility.
  • Molecular weight: The relatively high molecular weight of the compound may hinder solubility in certain organic solvents, depending on the solvent's characteristics.
  • pH sensitivity: The carboxyl group may alter its ionization state in varying pH environments, which can also affect solubility. For instance, at a lower pH, it can accept protons, leading to increased solubility.

In summary, while the compound is expected to be soluble in polar environments due to its hydrophilic functional groups, the exact solubility can vary depending on the specific solvent, temperature, and pH. Therefore, conducting empirical solubility tests in various conditions is recommended for precise characterization.

Interesting facts

Interesting Facts About 4-[[(8R,9S,13S,14S,16R,17R)-17-(3-carboxypropanoyloxy)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]oxy]-4-oxo-butanoic acid

This remarkable compound, with a complex structure, represents a fascinating intersection of medicinal chemistry and biochemistry. Its intricate molecular arrangement suggests potential transformative applications, particularly in pharmacology. Here are some captivating points to consider:

  • Biological activity: Compounds with similar frameworks are often investigated for their biological activity, particularly in the realm of hormone regulation and cancer therapy. The presence of multiple hydroxyl and carboxyl functional groups is critical in facilitating interactions with biological targets.
  • Synthetic challenge: The synthesis of such intricate molecules often poses significant challenges in terms of stereochemistry and regioselectivity, necessitating advanced techniques in organic synthesis.
  • Structure-activity relationship: Understanding how slight variations in structure affect biological activity is a key area of research in medicinal chemistry, making this compound an intriguing subject for a structure-activity relationship (SAR) study.
  • Natural product inspiration: Many compounds like this one draw inspiration from natural products, emphasizing the importance of nature in the design of new pharmaceuticals.
  • Potential applications: While research is ongoing, compounds with similar structural motifs have been explored for their potential benefits in anti-inflammatory and antitumor therapies, indicating that this particular compound could hold similar promise.

Overall, the study of 4-[[(8R,9S,13S,14S,16R,17R)-17-(3-carboxypropanoyloxy)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]oxy]-4-oxo-butanoic acid exemplifies the dynamic nature of chemical research and the potential for discovery in the field of medicine. As researchers delve deeper into its characteristics, we may uncover even more exciting applications and insights.

Synonyms
ESTRIOL SUCCINATE
514-68-1
Estriolo succinato
Oestriol succinate
Estrioli succinas
Oestrioli succinas
Estriol succinate [INN]
Succinate d'estriol
Succinato de estriol
Estriolo succinato [DCIT]
Sinapause (TN)
UNII-AS13K2DY03
Estriol succinate [INN:BAN]
AS13K2DY03
Estrioli succinas [INN-Latin]
Succinate d'estriol [INN-French]
Succinato de estriol [INN-Spanish]
EINECS 208-185-1
ESTRIOL SUCCINATE [MART.]
ESTRIOL SUCCINATE [WHO-DD]
Styptanon
Estriol 16alfa, 17beta-di (hydrogen succinate)
Estrioli succinas (INN-Latin)
succinylestriol
ESTRIOL SUCCINATE (MART.)
Succinate d'estriol (INN-French)
Succinato de estriol (INN-Spanish)
Sinapause
estriol-16,17-dihemisuccinate
G03CA04
G03CC06
208-185-1
styptanon (tn)
4-[[(8R,9S,13S,14S,16R,17R)-17-(3-carboxypropanoyloxy)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]oxy]-4-oxobutanoic acid
SCHEMBL345504
CHEBI:135790
VBRVDDFOBZNCPF-BRSFZVHSSA-N
DTXSID401023693
NS00032284
D07920
Q27274093