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Lidocaine

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Identification
Molecular formula
C14H22N2O2
CAS number
137-58-6
IUPAC name
4-acetamido-N-[2-(diethylamino)ethyl]benzamide
State
State

Lidocaine is typically used in its hydrochloride salt form, which is highly soluble in water. In its base form, it is slightly soluble in water but soluble in alcohol and chloroform.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.80
Boiling point (Kelvin)
623.95
General information
Molecular weight
234.34g/mol
Molar mass
234.3360g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is a white to off-white crystalline powder. It is practically odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 4-acetamido-N-[2-(diethylamino)ethyl]benzamide (C14H22N2O2)

The solubility of 4-acetamido-N-[2-(diethylamino)ethyl]benzamide is a fascinating aspect to explore, given its unique chemical structure. This compound exhibits varying solubility properties based on several factors:

  • Polarity: The presence of both hydrophobic (benzene ring) and hydrophilic (amide and amino groups) regions in the molecule contributes to its complex solubility profile. Its dual nature can facilitate solvation in different environments.
  • Solvent interaction: The compound is expected to have better solubility in polar organic solvents such as methanol and ethanol, as these solvents can engage in hydrogen bonding with the amide functionality.
  • Temperature dependency: Like many organic compounds, solubility may increase with temperature. As temperature rises, molecular interactions can weaken, allowing the compound to dissolve more readily.
  • Concentration limits: Upon increasing the concentration of 4-acetamido-N-[2-(diethylamino)ethyl]benzamide in a solvent, a saturation point will be reached, beyond which precipitation may occur.

In summary, understanding the solubility of this compound highlights the importance of intermolecular interactions and the influence of environmental conditions. As noted, the solubility will vary significantly depending on the nature of the solvent and the temperature, making it a pivotal factor in its practical applications.

Interesting facts

Interesting Facts about 4-Acetamido-N-[2-(diethylamino)ethyl]benzamide

4-Acetamido-N-[2-(diethylamino)ethyl]benzamide is a fascinating compound that plays a significant role in medicinal chemistry.

Key Characteristics:

  • Pharmaceutical Relevance: This compound is often investigated for its potential use in analgesics and anti-inflammatory medications.
  • Structurally Unique: It features an acetamido group, which contributes to its activity, alongside a diethylamino moiety that enhances its pharmacological profile.
  • Mechanism of Action: Compounds with similar structures often interact with biological targets by inhibiting specific enzymes or receptors, making them essential in drug design.

Research and Applications:

This compound is not just a theoretical construct; it is part of active research aimed at developing safer and more effective therapies. Its design reflects a balance between:

  • Potency
  • Selective action
  • Tolerability

Quotes from Researchers:

As one researcher stated, "The intricate interplay of functional groups in compounds like 4-acetamido-N-[2-(diethylamino)ethyl]benzamide represents both a challenge and an opportunity in the field of drug discovery."

The study of such compounds not only enhances our understanding of molecular interactions but also paves the way for innovations in treatment options for a variety of health conditions.

Synonyms
N-Acetylprocainamide
Acecainide
32795-44-1
NAPA
Acecainida
Acekainid
Acetylprocainamide
Acecainidum
N-Acetyloprokainamid
Acecainide [INN]
4'-((2-(Diethylamino)ethyl)carbamoyl)acetanilide
Acecainidum [INN-Latin]
Acecainida [INN-Spanish]
4-acetamido-N-[2-(diethylamino)ethyl]benzamide
N-acetylnovocainamide
n-acetyl-procainamide
N-Acetylprocaine amide
Acetylprocainamide, n-
Acecainide;NAPA
Benzamide, 4-(acetylamino)-N-(2-(diethylamino)ethyl)-
N-[2-(diethylamino)ethyl]-4-acetamidobenzamide
BRN 2868559
Procainamide-N-acetyl
N-Acetyl Procainamide
UNII-910Q707V6F
CHEBI:60728
Acecainide Monohydrochloride
ACECAINIDE [MI]
910Q707V6F
ACECAINIDE [WHO-DD]
CHEMBL1097
MLS000069490
DTXSID6048414
Monohydrochloride, Acecainide
ACETANILIDE, 4'-((2-(DIETHYLAMINO)ETHYL)CARBAMOYL)-
SMR000059070
Acecainidum (INN-Latin)
Acecainida (INN-Spanish)
4-Acetamido-N-(2-(diethylamino)ethyl)benzamide
Acekainid [Polish]
N-(4-{[2-(diethylamino)ethyl]carbamoyl}phenyl)ethanimidic acid
N Acetylprocainamide
N-Acetyloprokainamid [Polish]
N-(4-((2-(diethylamino)ethyl)carbamoyl)phenyl)ethanimidic acid
Opera_ID_1541
Spectrum3_001843
Lopac-A-5909
Epitope ID:140121
Lopac0_000009
BSPBio_003226
MLS001146871
SCHEMBL156943
N-Acetylprocainamide, >=99%
DTXCID4028387
KBio3_002726
HMS2232G18
HMS3372E09
BCP26213
HBA79544
HY-B1109
BDBM50151860
AKOS016614968
N-ACETYL PROCAINAMIDE(<30%)
CCG-204105
CS-4707
SDCCGSBI-0049998.P003
NCGC00015072-01
NCGC00015072-02
NCGC00015072-03
NCGC00015072-04
NCGC00015072-05
NCGC00015072-06
NCGC00015072-07
NCGC00015072-13
NCGC00023226-03
NCGC00023226-04
AS-57414
SBI-0049998.P002
1ST174444
DB-048268
N-Acetylprocainamide 1.0 mg/ml in Methanol
NS00008609
F85241
AB00384286_20
EN300-6492978
4-Acetylamino-N-(2-diethylamino-ethyl)-benzamide
Q4726688
4-(Acetylamino)-N-[2-(diethylamino)ethyl]benzamide #
BRD-K07753030-003-01-0
BRD-K07753030-003-11-9
BRD-K07753030-003-17-6
Z26393212