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Paracetamol acetate

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Identification
Molecular formula
C10H11NO4
CAS number
103-90-2
IUPAC name
(4-acetamidophenyl) acetate
State
State

At room temperature, paracetamol acetate is in a solid state. It is a stable compound under standard conditions and is commonly used in tablet or powder form in pharmaceutical applications.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.20
Boiling point (Celsius)
519.20
Boiling point (Kelvin)
792.40
General information
Molecular weight
237.25g/mol
Molar mass
237.2460g/mol
Density
1.2937g/cm3
Appearence

Paracetamol acetate is typically a white crystalline solid. It appears as a powder that is odorless and has a slightly bitter taste. This compound is often used in pharmaceutical formulations and displays good solubility in certain organic solvents.

Comment on solubility

Solubility of (4-acetamidophenyl) acetate

The solubility of (4-acetamidophenyl) acetate, a chemical compound with the formula C10H11NO2, can be characterized by a few key points:

  • Polar Nature: Due to the presence of the amide group (-NH2) and the ester group (-COO-), the compound exhibits polar characteristics, which generally enhances solubility in polar solvents.
  • Solvent Dependence: (4-acetamidophenyl) acetate is expected to dissolve well in polar protic solvents such as water and alcohols, while its solubility in non-polar solvents may be limited.
  • Temperature Influence: Solubility can increase with rising temperatures, thus elevating the kinetic energy and promoting dissolution.
  • Concentration Factors: As with many organic compounds, factors like concentration and pH of the solution may also play roles in determining how well the compound dissolves.

Understanding the solubility of (4-acetamidophenyl) acetate helps in predicting its behavior in various chemical environments, making it a valuable compound in applications such as pharmaceuticals and synthesis.

Interesting facts

Interesting Facts about (4-Acetamidophenyl) Acetate

(4-Acetamidophenyl) acetate, also known as acetaminophen acetate, is an intriguing compound widely studied for its therapeutic properties. Here are some fascinating insights into this compound:

  • Pharmaceutical Significance: It is a derivative of acetaminophen, a popular over-the-counter medication used for pain relief and fever reduction. Understanding its derivatives helps in improving drug efficacy and reducing side effects.
  • Synthetic Routes: The synthesis of (4-acetamidophenyl) acetate often involves acetylation reactions, where an acetamido group is added to a phenolic compound. This provides a great example of how modifying a compound's structure can influence its chemical behavior and properties.
  • Potential Research Applications: Research continues into the use of this compound in various formulations aimed at enhancing drug delivery systems or even developing new therapeutics that could target specific biological processes.
  • Toxicology Studies: Studying the toxicological effects of (4-acetamidophenyl) acetate is essential in understanding its safety profile and the implications of long-term use, particularly relevant in pediatric medicine where acetaminophen is commonly used.
  • Historical Context: The development and introduction of acetaminophen into medicine marked a significant advancement in pain management, showcasing the importance of compound modifications in creating effective pharmaceuticals.

As a compound that sits at the intersection of synthetic organic chemistry and pharmacology, (4-acetamidophenyl) acetate serves as an excellent model for students and researchers alike to explore the complexities of chemical modifications and their implications in real-world applications. The careful consideration of its structural features and methods of synthesis can yield further innovations in therapeutic advancements.


Synonyms
Diacetamate
2623-33-8
4-Acetamidophenyl acetate
Acetaminophen acetate
P-ACETOXYACETANILIDE
4-Acetoxyacetanilide
Diacetamat
Acetamide, N-[4-(acetyloxy)phenyl]-
Diacetamato
Diacetamatum
N-Acetyl-4-aminophenyl acetate
NSC 6083
NSC 33893
Diacetamate [INN:BAN]
BFG1TY61BG
Diacetamatum [INN-Latin]
N,o-diacetyl-4-aminopheno
Diacetamato [INN-Spanish]
NSC-6083
NSC-33893
DTXSID2046256
Acetanilide, 4'-hydroxy-, acetate (ester)
EINECS 220-077-6
DIACETAMATE [INN]
Acetamide, N-(4-(acetyloxy)phenyl)-
AI3-17250
DTXCID0026256
NSC6083
NSC33893
PARACETAMOL IMPURITY H [EP IMPURITY]
Diacetamatum (INN-Latin)
Diacetamato (INN-Spanish)
PARACETAMOL IMPURITY H (EP IMPURITY)
DAPAP
N,O-diacetyl-p-aminophenol
N,O-diacetyl-para-aminophenol
Acetanilide, 4'-hydroxy-, acetate (ester) (8CI)
220-077-6
4'-Acetoxyacetanilide
N,O-Diacetyl-4-aminophenol
(4-acetamidophenyl) acetate
N-[4-(Acetyloxy)phenyl]acetamide
4-(Acetylamino)phenyl acetate
Acetaminophen Acetate (Acetaminophen Impurity)
MFCD00059205
NCGC00160605-01
Acetanilide, acetate (ester)
4-(Acetylamino)phenyl Acetate (N,O-Diacetyl-4-aminophenol)
O-Acetylparacetamol
UNII-BFG1TY61BG
4'-Hydroxyacetanilide Acetate
Acetamide,N-[4-(acetyloxy)phenyl]-
Maybridge1_006198
Paracetamol EP Impurity H
O,N-Diacetyl-4-aminophenol
MLS006011695
SCHEMBL863106
CHEMBL2106185
HMS559B16
HMS3264O15
Pharmakon1600-01504515
Acetanilide, 4'-hydroxy-, acetate
Tox21_111931
4-Acetamidophenyl acetate (Standard)
HY-66004R
NSC758889
STL034244
AKOS002255264
Acetic acid 4-acetylamino-phenyl ester
CCG-213946
IA16944
NSC-758889
AS-48014
DA-60716
HY-66004
SMR002530013
SY105212
CAS-2623-33-8
SBI-0207076.P001
A0067
CS-0005650
NS00028061
VU0606051-1
F17539
AB01563223_01
EN300-7392397
AG-670/32634053
SR-01000872731
SR-01000872731-1
BRD-K93611241-001-01-4
BRD-K93611241-001-02-2
Q27274637
Z29109552
F3228-0190
N-[4-(Acetyloxy)phenyl]acetamide;4'-Acetoxyacetanilide;Acetaminophen impurity H
InChI=1/C10H11NO3/c1-7(12)11-9-3-5-10(6-4-9)14-8(2)13/h3-6H,1-2H3,(H,11,12