Interesting facts
Interesting Facts about 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,3,5-triazin-2-one
This fascinating compound is a derivative of triazine, a class of synthetic compounds known for their diverse applications in pharmaceuticals and agriculture. Here are some intriguing aspects of this compound:
- Structural Complexity: The compound features a unique tricyclic structure that combines both triazine and a sugar-like moiety. This structural diversity opens up possibilities for various biological interactions.
- Pharmacological Potential: The presence of hydroxyl groups enhances its reactivity and solubility, potentially leading to improved pharmacokinetic properties. Compounds featuring similar structures are often investigated as antiviral agents.
- Natural Product Inspiration: The sugar unit in this compound resembles natural sugar structures, suggesting it could mimic natural compounds in biological systems, which is a useful attribute in drug design.
- Hydroxymethyl Group: The hydroxymethyl group in this structure is noteworthy as it can undergo various chemical reactions, making the compound a valuable candidate for further synthetic modifications.
- Chirality: The chirality indicated by the (2R,3R,4S,5R) configuration implies that this compound exists in non-superimposable mirror image forms. Chirality plays a critical role in the biological activity of compounds, and subtle differences in stereochemistry can lead to significant variations in behavior and efficacy.
Researchers are continually exploring the potential of compounds like this one, delving into their capabilities not only in human medicine but also in other fields such as agriculture and material science. The journey of synthesizing and characterizing such complex molecules is both challenging and rewarding, indicative of the intricate world of chemical science.
Synonyms
5-azacytidine
Azacitidine
320-67-2
Azacytidine
Ladakamycin
Vidaza
Mylosar
5-azacitidine
Azacitidina
Azacitidinum
Azacitidinum [INN-Latin]
Azacitidina [INN-Spanish]
Antibiotic U 18496
5-AZAC
Onureg
NSC-102816
U-18496
CCRIS 60
4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one
HSDB 6879
4-Amino-1-beta-d-ribofuranosyl-1,3,5-triazin-2(1H)-one
WR-183027
EINECS 206-280-2
UNII-M801H13NRU
5-AZCR
5AzaC
5 AZC
BRN 0620461
CHEBI:2038
M801H13NRU
U 18496
DTXSID9020116
5-AC
4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one
MFCD00006539
NSC102816
U-18,496
DTXCID10116
NCI-C01569
4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
NSC 102816
Onureg (CC-486; oral azacitidine)
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
s-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-
NCGC00090851-04
5 Azacytidine
AZACITIDINE (IARC)
AZACITIDINE [IARC]
Azacitidinum (INN-Latin)
Azacitidina (INN-Spanish)
AZACITIDINE (MART.)
AZACITIDINE [MART.]
AZACITIDINE (USP-RS)
AZACITIDINE [USP-RS]
C8H12N4O5
1,3,5-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-
1,3,5-Triazin-2(1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-
5-Aza-xylo-cytidine
SMR000857239
Vidaza (TN)
5-aza-CR
SR-01000075662
wr 183027
Azacitidine;5-AzaC;Ladakamycin
azacitidine for
Azacitidine (JAN/USAN/INN)
Azacitidine [USAN:INN:BAN]
5-Azacytidine?
NS-17
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,3,5-triazin-2-one
CAS-320-67-2
5-AzadCyD
Azacitidine (Vidaza)
2-(beta-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-one
Spectrum_001262
4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one
AZACITIDINE [MI]
Spectrum2_000786
Spectrum3_001509
Spectrum4_000922
Spectrum5_001166
AZACITIDINE [INN]
AZACITIDINE [JAN]
5-Azacytidine (Standard)
AZACITIDINE [HSDB]
AZACITIDINE [USAN]
MolMap_000062
4-Amino-1-.beta.-D-ribofuranosyl-s-triazin-2(1H)-one
A 2385
AZACITIDINE [VANDF]
AZACITIDINEAZACITIDINE
SCHEMBL3741
5-ACZ
CHEMBL1489
Azacitidine (5-Azacytidine)
Lopac0_000035
AZACITIDINE [WHO-DD]
BSPBio_003157
KBioGR_001444
KBioGR_002556
KBioSS_001742
KBioSS_002565
MLS001333121
MLS001333122
MLS002153249
MLS002548894
DivK1c_000125
SPECTRUM1502111
SPBio_000892
AZACITIDINE [EMA EPAR]
GTPL6796
BCBcMAP01_000083
HMS500G07
KBio1_000125
KBio2_001742
KBio2_002556
KBio2_004310
KBio2_005124
KBio2_006878
KBio2_007692
KBio3_002657
KBio3_003034
NMUSYJAQQFHJEW-KVTDHHQDSA-
AZACITIDINE [ORANGE BOOK]
L01BC07
pyrimidine antimetabolite: inhibits nucleic acid replication
cMAP_000082
NINDS_000125
HMS1921J22
HMS2092D08
HMS2231F15
HMS3259D19
HMS3260G11
Pharmakon1600-01502111
5-Azacytidine, >=98% (HPLC)
Tox21_111032
Tox21_302985
Tox21_500035
BDBM50424715
CCG-39046
HB1374
HY-10586R
NSC758186
s1782
AKOS015896938
Azacitidine, 5-AzaC;Vidaza;CC-486
Tox21_111032_1
CS-1287
DB00928
LP00035
NA02947
NC00672
NSC-758186
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triaz
IDI1_000125
NSC 103-627
NCGC00090851-01
NCGC00090851-02
NCGC00090851-03
NCGC00090851-05
NCGC00090851-06
NCGC00090851-07
NCGC00090851-08
NCGC00090851-10
NCGC00090851-14
NCGC00090851-18
NCGC00090851-22
NCGC00178234-01
NCGC00256541-01
NCGC00260720-01
AS-13697
HY-10586
SRI-10756_10
SRI-10756_12
DB-006955
SL-000003
EU-0100035
NS00008631
D03021
EN300-118700
F10504
Q416451
SR-01000075662-1
SR-01000075662-3
SR-01000075662-7
4-Amino-1-beta-D-ribofuranosyl-D-triazin-2(1H)-one
BRD-K03406345-001-02-1
BRD-K03406345-001-21-1
BRD-K03406345-001-27-8
Z1515383340
Azacitidine, United States Pharmacopeia (USP) Reference Standard
4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; Ladakamycin
Azacitidine, Pharmaceutical Secondary Standard; Certified Reference Material
1401238-97-8
206-280-2
5-Azacytidine, Hybri-Max(TM), gamma-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
5AE
InChI=1/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
Solubility of 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,3,5-triazin-2-one
The solubility of 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,3,5-triazin-2-one can be influenced by several key factors:
It is important to note that while solubility in water may be significant due to the factors mentioned above, solubility in organic solvents can vary widely. In general:
Understanding the solubility properties of this compound is crucial for its applications in various fields, including pharmaceuticals and materials science. Investigating its solubility can provide insights into its behavior in different chemical environments and influence its effectiveness in practical applications.