Interesting facts
Interesting Facts About 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidin-2-one
This compound, often appreciated in the field of medicinal chemistry, belongs to a class of molecules known for their biological activity. Here are some key highlights about this interesting molecule:
- Structure and Chirality: The molecule features a complex chiral center, specifically at the tetrahydrofuran ring, contributing to its unique properties and interactions within biological systems.
- Pharmacological Potential: Compounds with similar structures are often investigated for their potential as antiviral or anticancer agents, illustrating the significance of this compound in drug discovery.
- Fluorine's Role: The presence of a fluorine atom in the pyrimidine ring enhances metabolic stability and can significantly improve the binding affinity towards target enzymes or receptors, an essential aspect in the design of pharmaceuticals.
- Sugar-Like Moiety: The inclusion of a sugar-like structure such as the 3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran promotes the idea of "mimicking" natural substrates, aiding in better cellular uptake and activity.
- Research and Applications: Many researchers are drawn to explore the structure-activity relationships of molecules like this, with a goal to design newer variants that exhibit enhanced efficacy and reduced toxicity profiles.
In conclusion, the exploration of compounds like 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidin-2-one is a testament to the intricate connection between chemical structure and biological functionality, showcasing the endless possibilities within the realm of organic and medicinal chemistry.
Synonyms
Ara-fluorocytosine
4298-10-6
5-Fluorocytosine arabinoside
Arafluorocytosine
1-beta-D-Arabinofuranosyl-5-fluorocytosine
87PGS3A0AZ
beta-D-Arabinofuranosyl-5-fluorocytosine
4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidin-2-one
Ara-FC
Fluorocytosine arabinoside
2(1H)-Pyrimidinone, 4-amino-1-beta-D-arabinofuranosyl-5-fluoro-
NSC-529180
FCA
.beta.-D-Arabinofuranosyl-5-fluorocytosine
NSC 529180
1-.beta.-D-Arabinofuranosyl-5-fluorocytosine
Cytosine, 1-.beta.-D-arabinofuranosyl-5-fluoro-
5-F-Ara-C
UNII-87PGS3A0AZ
CYTOSINE, 1-beta-D-ARABINOFURANOSYL-5-FLUORO-
SCHEMBL1230711
DTXSID00195602
STRZQWQNZQMHQR-MNCSTQPFSA-N
5-FLUORO-ARABINOSYLCYTOSINE
2(1H)-Pyrimidinone, 4-amino-1-beta-D-arabinofuranosyl- 5-fluoro-
AKOS040750559
5-fluoro-1-beta-D-arabinofuranosylcytosine
Q27269833
2(1H)-PYRIMIDINONE, 4-AMINO-1-.BETA.-D-ARABINOFURANOSYL-5-FLUORO-
4-Amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidin-2(1H)-one
4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidin-2-one
Solubility of 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidin-2-one
The complex structure of 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidin-2-one presents intriguing characteristics regarding its solubility. Understanding solubility is crucial as it affects the compound's bioavailability and overall application potential. Here are some key points to consider:
In summary, while the solubility of 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidin-2-one is likely influenced by both polar and non-polar characteristics, precise solubility data would require empirical testing under controlled conditions to fully understand its behavior in various solvents.