Interesting facts
Interesting Facts about 4-Amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one, a complex organic compound, is noteworthy for several reasons:
- Pharmaceutical Relevance: This compound is significant in medicinal chemistry, often studied for its potential applications as an anti-viral or anti-cancer agent, showcasing the intricate connection between structure and biological activity.
- Sterochemical Importance: The compound features a tetrahydrofuran ring with specific stereochemical configurations (2R,5S), which can greatly influence its reactivity and interaction with biological targets. Understanding stereochemistry is crucial for drug design, as different isomers can have distinctly different effects.
- Functional Groups: The presence of an amino group and a hydroxymethyl group can participate in hydrogen bonding, making this compound an interesting candidate for studying intermolecular interactions in biological systems.
- Structural Diversity: The pyrimidine ring in this compound contributes to its structural uniqueness, providing a versatile platform for derivatization and modification, essential for developing new derivatives with enhanced properties.
In studying this compound, researchers may ask:
How do the structural elements of 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one affect its biological activities?
This inquiry highlights the ongoing efforts in the field of drug discovery to optimize pharmacological profiles through molecular modifications.
Overall, 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one serves as a remarkable example of how intricate molecular designs can lead to valuable pharmaceutical advancements.
Synonyms
zalcitabine
Dideoxycytidine
7481-89-2
2',3'-DIDEOXYCYTIDINE
HIVID
4-Amino-1-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Hivid (TN)
CCRIS 692
zalcitabina
NSC-606170
HSDB 7156
DDC (DDC)
6L3XT8CB3I
BRN 0654956
DTXSID0023747
CHEBI:10101
dideoxycytidine (DDC)
4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one
Zalcitabine [USAN:USP:INN:BAN]
ZALCITABINE [MI]
ZALCITABINE [INN]
ZALCITABINE [JAN]
ZALCITABINE [HSDB]
ZALCITABINE [IARC]
ZALCITABINE [USAN]
ZALCITABINE [VANDF]
4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
ZALCITABINE [MART.]
ZALCITABINE [USP-RS]
ZALCITABINE [WHO-DD]
Ro-242027000
DTXCID703747
Ro-24-2027000
Zalcitabine (dideoxycytidine,ddc)
ZALCITABINE [ORANGE BOOK]
ZALCITABINE [USP IMPURITY]
5-25-14-00313 (Beilstein Handbook Reference)
ddC (Antiviral)
4-AMINO-1-[(2R,5S)-5-(HYDROXYMETHYL)OXOLAN-2-YL]-1,2-DIHYDROPYRIMIDIN-2-ONE
ZALCITABINE (IARC)
ZALCITABINE (MART.)
ZALCITABINE (DIDEOXYCYTIDINE,DDC) [VANDF]
ZALCITABINE (USP-RS)
Ro-242027000/Ro-24-2027-000
ZALCITABINE (USP IMPURITY)
Zalcitabine (USAN:USP:INN:BAN)
2',3' Dideoxycytidine
zalcitabinum
4-amino-1-((2R,5S)-5-(hydroxymethyl)oxolan-2-yl)pyrimidin-2-one
4-amino-1-((2R,5S)-5-(hydroxymethyl)oxolan-2-yl)-1,2-dihydropyrimidin-2-one
J05AF03
620-762-3
wregkurfctugrc-poybymjqsa-n
ddCyd
Cytidine, 2',3'-dideoxy-
ddC
Zalcitibine
Ro 24-2027/000
Ro-24-2027/000
MFCD00012188
CHEMBL853
NCGC00090705-08
2,3-dideoxycytidine
NSC 606170
NSC606170
4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
SMR000058253
Hivid(TM)
Interferon AD + ddC
ddC & GM-CSF
ddC & sCD4
PC-SOD & ddC
UNII-6L3XT8CB3I
Zalcitabine (JAN/USP/INN)
Zalcitabine?
DS-4152 & ddC
1-(2,3-Dideoxy-beta-D-ribofuranosyl)cytosine
ddC & NP (from PHCA or HSA)
SRI-7707
2',3'-Dideoxycytidine;ddC;Dideoxycytidine
CAS-7481-89-2
KS-1130
ddC & IFN.alpha.
.beta.-D-DDC
Zalcitabine (Standard)
Prestwick0_001037
Prestwick1_001037
Prestwick2_001037
Prestwick3_001037
ddC & Interferon.alpha.
2', 3'-dideoxycytidine
bmse000712
UPCMLD-DP115
D 5782
SCHEMBL3598
TimTec1_004969
Lopac0_000360
BSPBio_001253
3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine
MLS000069636
MLS000759540
MLS001055363
MLS001424210
MLS006011951
SPBio_003104
BPBio1_001378
GTPL4828
UPCMLD-DP115:001
Zalcitabine - Bio-X trade mark
2',3'-Dideoxycytidine & sCD4(soluble recombinant protein)
GLXC-06578
HMS1548B19
HMS1571O15
HMS2051H18
HMS2090C12
HMS2098O15
HMS2236N08
HMS3261G21
HMS3715O15
Pharmakon1600-01502360
.beta.-D-2',3'-Dideoxycytidine
Zalcitabine, 2'3'-Dideoxycytidine
BCP13878
Tox21_113491
Tox21_201655
Tox21_303169
Tox21_500360
AC-824
BDBM50145605
HY-17392R
Lecithinized superoxide dismutase & .beta.-D-2',3'-Dideoxycytidine
NSC759655
s1719
AKOS015854844
AKOS015894505
Tox21_113491_1
CCG-101050
CS-1110
DB00943
LP00360
NC00300
ND06559
NSC-759655
SDCCGSBI-0050348.P002
SRI-7707-13
SRI-7707-14
SRI-7707_15
SRI-7707_17
NCGC00090705-01
NCGC00090705-02
NCGC00090705-03
NCGC00090705-05
NCGC00090705-06
NCGC00090705-07
NCGC00090705-09
NCGC00090705-10
NCGC00090705-11
NCGC00090705-13
NCGC00090705-15
NCGC00090705-24
NCGC00090705-25
NCGC00179242-01
NCGC00257202-01
NCGC00259204-01
NCGC00261045-01
BD164564
BP-58631
HY-17392
ddC;Dideoxycytidine;2',3'-Dideoxycytidine
2',3'-Dideoxycytidine & Interferon.alpha.
2',3'-Dideoxycytidine, >=98% (HPLC)
DB-019728
D3581
EU-0100360
NS00005543
SW197364-4
C07207
C76390
D00412
EN300-120633
Cytidine, 2',3'-dideoxy- & Interferon.alpha.
Zalcitabine;ddC;Hivid;2',3'-Dideoxy-D-cytidine
SR-01000075822
SR-01000736919
Q2344582
SR-01000075822-1
SR-01000736919-5
BRD-K85925969-001-16-6
BRD-K85925969-001-17-4
Cytidine, 2',3'-dideoxy- & Colony-stimulating factor
Z1550648753
2',3'-Dideoxycytidine;ddC;Hivid;2',3'-Dideoxy-D-cytidine
Zalcitabine, United States Pharmacopeia (USP) Reference Standard
2 inverted exclamation marka,3 inverted exclamation marka-Dideoxycytidine
4-Amino-1-(5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
.beta.-D-2',3'-Dideoxycytidine & Granulocyte-macrophage colony-stimulating factor
Solubility of 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
This compound displays interesting solubility characteristics, making it a subject of interest in various applications. Its solubility can be described by considering several factors:
It is important to note that solubility can be influenced by temperature and pH of the solution, with increased temperature often leading to enhanced solubility. Furthermore, the solubility in different media necessitates empirical validation for precise applications.
In summary, 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one exhibits:
Understanding solubility is crucial for optimizing its use in pharmaceutical formulations and other chemical processes!