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Kanamycin A

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Identification
Molecular formula
C18H36N4O11
CAS number
59-01-8
IUPAC name
4-amino-2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-6-(hydroxymethyl)tetrahydropyran-3,5-diol
State
State

Kanamycin A at room temperature is typically found in a solid state as a powder or crystalline form. It is highly soluble in water, which makes it useful as an injectable antibiotic.

Melting point (Celsius)
230.00
Melting point (Kelvin)
503.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
484.54g/mol
Molar mass
484.4670g/mol
Density
1.6000g/cm3
Appearence

Kanamycin A is typically a white to off-white powder. It is often found as a crystalline solid or powder with a slight odor. The appearance can vary slightly depending on the form it is in, such as a sulfate salt.

Comment on solubility

Solubility of 4-amino-2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-6-(hydroxymethyl)tetrahydropyran-3,5-diol

The solubility of the compound 4-amino-2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-6-(hydroxymethyl)tetrahydropyran-3,5-diol can be largely influenced by its structural features, particularly the presence of multiple amino and hydroxyl groups. Here are some key points regarding its solubility:

  • Hydrophilicity: The numerous hydroxyl (-OH) groups generally enhance the solubility in polar solvents, such as water, due to hydrogen bonding possibilities.
  • Amino Groups: With multiple amino (-NH2) groups present, the compound may also exhibit strong interactions with water, further contributing to its solubility profile.
  • Structural Complexity: The overall complex molecular structure might pose challenges to solubility in non-polar solvents, which could limit its applications in related fields.
  • pH Dependence: Solubility may vary with changes in pH, since amino and hydroxyl groups can participate in protonation or deprotonation processes, affecting solubility behavior.

Overall, while the abundance of hydroxyl and amino groups suggests favorable solubility in polar solvents, the intricate structure may present some limitations in certain solvent systems. Thus, a comprehensive study through experimental assays would be beneficial to determine precise solubility values in various conditions. As a rule of thumb, "like dissolves like": in this case, we would expect this compound to flourish in polar environments, demonstrating robust solubility characteristics.

Interesting facts

Interesting Facts about 4-amino-2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-6-(hydroxymethyl)tetrahydropyran-3,5-diol

The compound 4-amino-2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-6-(hydroxymethyl)tetrahydropyran-3,5-diol is a complex structure that highlights the fascinating world of organic chemistry. Here are some intriguing aspects of this compound:

  • Structural Complexity: The presence of multiple functional groups, such as amino and hydroxy groups, suggests its potential biological activity and ability to interact with various biological systems.
  • Potential Therapeutic Applications: Due to its intricate structure, this compound is of interest in the pharmaceutical industry. Compounds with similar structures often serve as precursors or active pharmaceutical ingredients (APIs) in drug development.
  • Synthetic Pathways: The synthesis of such a complex molecule can involve various methods such as condensation reactions and protection/deprotection strategies, showcasing the creativity required in organic synthesis.
  • Biological Significance: Compounds with multiple amino and hydroxyl groups can often play significant roles in biological systems, such as acting as enzyme inhibitors or influencing metabolic pathways.

As chemists and researchers delve deeper into the characteristics of such compounds, it becomes evident that understanding their unique attributes can lead to groundbreaking discoveries in medicine and beyond. The field of medicinal chemistry continuously evolves, and compounds like this one pave the way for future innovations and therapies.

Synonyms
DTXSID20859714
4,6-Diamino-3-[(3-amino-3-deoxyhexopyranosyl)oxy]-2-hydroxycyclohexyl 2-amino-2-deoxyhexopyranoside