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Isoniazid Salicylic Acid

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Identification
Molecular formula
C13H11N3O3
CAS number
5480-92-0
IUPAC name
4-amino-2-hydroxy-benzoic acid;pyridine-4-carbohydrazide
State
State

At room temperature, Isoniazid Salicylic Acid is in a solid state.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.15
Boiling point (Celsius)
302.00
Boiling point (Kelvin)
575.15
General information
Molecular weight
308.30g/mol
Molar mass
308.3000g/mol
Density
1.8000g/cm3
Appearence

Isoniazid Salicylic Acid appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 4-Amino-2-hydroxy-benzoic Acid and Pyridine-4-carbohydrazide

The solubility characteristics of 4-amino-2-hydroxy-benzoic acid (commonly known as salicylic acid) and pyridine-4-carbohydrazide can vary based on several factors, including temperature and the presence of other solutes. Here are some key points to consider:

4-Amino-2-hydroxy-benzoic acid

  • Solvent Dependence: This compound is typically soluble in water, particularly in warm conditions, due to the presence of the carboxylic acid and hydroxyl functional groups that facilitate hydrogen bonding.
  • pH Influence: The solubility can be significantly influenced by the pH of the solution. In more alkaline conditions, the deprotonation of the acid can lead to increased solubility.
  • Organic Solvents: It also exhibits solubility in organic solvents like ethanol and methanol, allowing it to be utilized in various chemical reactions and formulations.

Pyridine-4-carbohydrazide

  • Aqueous Solubility: This compound's solubility in water is relatively low, limiting its application in aqueous environments.
  • Organic Solvents: It shows better solubility in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol, making it more versatile in organic synthesis.

In summary, while the solubility of C7H7N1O3 varies greatly with environmental factors, understanding these aspects helps in achieving optimal conditions for its use in laboratories and industrial processes. Always consider the detailed conditions when evaluating solubility to maximize efficiency and effectiveness in applications.

Interesting facts

Interesting Facts about 4-amino-2-hydroxy-benzoic acid and Pyridine-4-carbohydrazide

In the realm of organic chemistry, the compounds 4-amino-2-hydroxy-benzoic acid and pyridine-4-carbohydrazide showcase the diversity and complexity of aromatic compounds. Here are some captivating insights about these two intriguing substances:

4-amino-2-hydroxy-benzoic acid

  • This compound is an important derivative of salicylic acid and is often referred to as 4-Amino Salicylic Acid.
  • It serves as a precursor in the synthesis of various pharmaceuticals, particularly in the treatment of tuberculosis due to its effectiveness against multidrug-resistant strains.
  • It is renowned for its ability to act as a __mild antifungal agent__ and has potential uses in the development of new therapeutic agents.

Pyridine-4-carbohydrazide

  • Known for its heterocyclic nature, this compound is a key player in medicinal chemistry, displaying potential anti-tubercular and anti-cancer properties.
  • Pyridine itself is a vital building block in the synthesis of various bioactive molecules, and compounds like pyridine-4-carbohydrazide often extend its application range.
  • Research has shown that modifications of this compound can lead to enhanced pharmacological activities, making it a focus for drug development.

Both of these compounds highlight the intersection of natural products and synthetic chemistry, revealing their potential roles in drug formulation and therapeutic applications. As we further explore the effects and mechanisms of these compounds, their significance in medicinal chemistry continues to grow.

Synonyms
Pasiniazid
2066-89-9
Pasiniazide
Pasiniazida
Pasiniazidum
Isoniazid 4-aminosalicylate
Pasiniazid [INN:DCF]
Paraniazide
Pasiniazide [INN-French]
Pasiniazidum [INN-Latin]
Pasiniazida [INN-Spanish]
UNII-83J17CN0MN
RD 328
DIPASIC
FINTOZID
NIDRAPAS
PASCIDABER
PASHAIN
PAS-HIDRACIDA
PARASAL INH
PASINIAZID [INN]
EINECS 218-183-2
NSC-758447
PASINIAZID [WHO-DD]
GEWO-399
DTXSID50174700
ISONIAZID P-AMINO-SALICYLATE
Isonicotinic acid hydrazide, mono(4-aminosalicylate)
RD-328
NSC 758447
ISONIAZID 4-AMINOSALICYLATE [MI]
Isonicotinic acid hydrazide p-aminosalicylate
4-Pyridinecarboxylic acid, hydrazide, mono(4-amino-2-hydroxybenzoate)
Pasiniazide (INN-French)
Pasiniazidum (INN-Latin)
Pasiniazida (INN-Spanish)
P-AMINOSALICYLIC ACID ISONICOTINYL HYDRAZIDE
Fintosid
isoniazide 4-aminosalicylate
DTXCID7097191
218-183-2
83J17CN0MN
Isonicotinic acid hydrazide compound with 4-amino-salicylic acid
4-amino-2-hydroxybenzoic acid;pyridine-4-carbohydrazide
4-Pyridinecarboxylic acid hydrazide 4-amino-2-hydroxybenzoate
Paraniazide;Pasiniazide;Isonicotinic acid hydrazide p-aminosalicylate
Spectrum_001721
Spectrum2_001936
Spectrum3_000775
Spectrum4_001203
Spectrum5_001203
BSPBio_002450
KBioGR_001606
KBioSS_002201
DivK1c_000327
SCHEMBL865578
SPECTRUM1503381
SPBio_001971
Pasiniazid, analytical standard
4-amino-2-hydroxybenzoic acid; pyridine-4-carbohydrazide
CHEMBL1496806
HMS501A09
KBio1_000327
KBio2_002201
KBio2_004769
KBio2_007337
KBio3_001670
4-amino-2-hydroxy-benzoic acid; pyridine-4-carbohydrazide
Isoniazid & p-Aminosalicylic acid
NINDS_000327
RKPHTRVPGYGVQD-UHFFFAOYSA-N
HMS1922C06
Pharmakon1600-01503381
HY-B1048
CCG-39463
NSC758447
s4404
AKOS026749897
CS-4569
IDI1_000327
NCGC00021150-01
NCGC00021150-02
NCGC00021150-03
NCGC00021150-04
NCGC00024460-02
NCGC00024460-03
AS-56163
DA-56607
SBI-0051819.P002
isonicotinohydrazide4-amino-2-hydroxybenzoate
NS00081437
SW199569-2
isonicotinic acid hydrazide P-*aminosalicylate
isonicotinohydrazide 4-amino-2-hydroxybenzoate
D70306
EN300-12640402
SR-01000000138
SR-01000000138-2
Q27269437
4-amino-2-hydroxybenzoic acid,pyridine-4-carbohydrazide
4-Pyridinecarboxylic acid hydrazide & 4-Aminosalicylic acid