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Phenibut

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Identification
Molecular formula
C10H13NO2
CAS number
1078-21-3
IUPAC name
4-amino-2-phenyl-butanoic acid
State
State

At room temperature, Phenibut is in a solid state. This white crystalline powder can easily dissolve in water when in its hydrochloride form, which is commonly used in supplements and pharmaceutical preparations. In its free amino acid form, it is less soluble in water but still retains its solid state under standard laboratory conditions.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.00
Boiling point (Celsius)
383.90
Boiling point (Kelvin)
657.10
General information
Molecular weight
179.22g/mol
Molar mass
179.2160g/mol
Density
1.2000g/cm3
Appearence

Phenibut is a crystalline solid that appears as a white powder. It often comes in the form of its hydrochloride salt, which enhances its solubility in water. The powder is usually very fine and can clump together easily when exposed to humidity due to its hygroscopic nature.

It has a slightly bitter taste, which is typical of many amino acid derivatives. The crystalline structure is not usually visible to the naked eye, as the powder is often milled to a fine consistency for use.

Comment on solubility

Solubility of 4-amino-2-phenyl-butanoic acid

The solubility of 4-amino-2-phenyl-butanoic acid (commonly known as phenylalanine) is a fascinating topic due to its implications in biochemistry and nutritional science. This compound exhibits varied solubility characteristics influenced by several factors, which can be summarized as follows:

  • Polar Nature: Due to the presence of an amino group (-NH2) and a carboxylic acid group (-COOH), 4-amino-2-phenyl-butanoic acid has a polar structure. This polarity facilitates solubility in water and other polar solvents.
  • Solvent Interaction: The compound is more soluble in acidic or neutral conditions compared to alkaline conditions, as the carboxylic acid may become deprotonated, decreasing solubility in high pH environments.
  • Temperature Dependency: Increasing temperature can typically enhance solubility, allowing for greater dissolution rates, which is particularly noticeable in a variety of solvents.

In summary, the solubility of 4-amino-2-phenyl-butanoic acid is significantly influenced by its structural properties and the nature of the solvent. It's important to note that while it is generally considered soluble in water, the precise solubility can vary depending on conditions such as temperature and pH. Therefore, when considering the use of this compound in formulations, paying close attention to these factors is vital.

Interesting facts

Interesting Facts about 4-Amino-2-phenyl-butanoic Acid

4-Amino-2-phenyl-butanoic acid, often referred to in the scientific community as L-phenylalanine, is a fascinating compound with a variety of applications and properties. Here are some engaging highlights about this compound:

  • Amino Acid Importance: L-phenylalanine is one of the twenty standard amino acids and serves as a building block for proteins. It plays a crucial role in biological processes and is essential for human health.
  • Precursor to Neurotransmitters: This amino acid is significant because it is a precursor to important neurotransmitters such as dopamine, norepinephrine, and epinephrine, all of which are vital for mood regulation and cognitive function.
  • Role in Diet: L-phenylalanine is an essential amino acid, meaning it must be obtained through the diet. Foods rich in protein, such as meat, fish, eggs, dairy products, and some nuts, contain high levels of this compound.
  • Phenylketonuria (PKU): An important consideration regarding L-phenylalanine is its connection to PKU, a genetic disorder that results in the inability to metabolize this amino acid properly. Individuals with PKU must adhere to a strict diet low in phenylalanine to avoid serious health issues.
  • Therapeutic Uses: Research suggests that L-phenylalanine may have potential therapeutic applications, such as aiding in the management of depression and chronic pain, although more studies are needed to fully understand its effectiveness.

In conclusion, 4-amino-2-phenyl-butanoic acid is much more than just a structural component of proteins; it is a compound deeply interwoven with various physiological and biological functions. Its link to health conditions and potential therapeutic benefits makes it a topic of ongoing research and interest in the fields of biochemistry and pharmacology.

Synonyms
13080-10-9
alpha-Phenyl gaba
4-Amino-2-phenyl-butyric acid
alpha-Phenyl-gamma-aminobutyric acid
BRN 2804881
BUTYRIC ACID, 4-AMINO-2-PHENYL-
4-amino-2-phenylbutyric acid
4-amino-2-phenylbutanoic acid
phenyl-gamma-aminobutyric acid
Benzeneacetic acid, alpha-(2-aminoethyl)-
4-amino-2-phenylbutanoicacid
4-Amino-2-phenyl-butyricacid
SCHEMBL1613696
SCHEMBL11502865
DTXSID20926915
CHEBI:177094
butanoic acid, 4-amino-2-phenyl-
AKOS006277679
DB-349083
A57125